42c48fad83b539a60f4bdd476c76fa46 pmc_34946123.pdf 53ccdc524bdf188cf499e1aaa8fd77e3901d4d74 pmc_34946123.pdf 74506761fafabf03f2e5730c06025eb8d1ee3a0681f24b3bc6a8e0e82a8d555c pmc_34946123.pdf Title: Microorganisms as Shapers of Human Civilization, from Pandemics to Even Our Genomes: Villains or Friends? A Historical Approach Subject: Universal history is characterized by continuous evolution, in which civilizations are born and die. This evolution is associated with multiple factors, among which the role of microorganisms is often overlooked. Viruses and bacteria have written or decisively contributed to terrible episodes of history, such as the Black Death in 14th century Europe, the annihilation of pre-Columbian American civilizations, and pandemics such as the 1918 Spanish flu or the current COVID-19 pandemic caused by the coronavirus SARS-CoV-2. Nevertheless, it is clear that we could not live in a world without these tiny beings. Endogenous retroviruses have been key to our evolution and for the regulation of gene expression, and the gut microbiota helps us digest compounds that we could not otherwise process. In addition, we have used microorganisms to preserve or prepare food for millennia and more recently to obtain drugs such as antibiotics or to develop recombinant DNA technologies. Due to the enormous importance of microorganisms for our survival, they have significantly influenced the population genetics of different human groups. This paper will review the role of microorganisms as “villains” who have been responsible for tremendous mortality throughout history but also as “friends” who help us survive and evolve. Keywords: pandemics; plague; Yersinia pestis; influenza; COVID-19; SARS-CoV-2; microbiota; endogenous retrovirus; biotechnology; population genetics Author: Francisco Rodríguez-Frías, Josep Quer, David Tabernero, Maria Francesca Cortese, Selene Garcia-Garcia, Ariadna Rando-Segura and Tomas Pumarola Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Dec 7 03:20:14 2021 CET ModDate: Tue Dec 7 03:29:52 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 54 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2849495 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DRYAID+VnURWPalladioL Type 1 Custom yes yes no 10 0 JRAVWX+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 UIQNVQ+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 FDYGJS+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 SIXRFS+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 FDYKIK+CMSY10 Type 1 Builtin yes yes no 78 0 OFJPKK+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 100 0 OFJPKM+PalatinoLinotype TrueType WinAnsi yes yes no 103 0 OFJPKO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 106 0 CELKDK+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 120 0 CELKDM+PalatinoLinotype TrueType WinAnsi yes yes no 123 0 CELKEO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 126 0 OFJPKK+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 149 0 OFJPKM+PalatinoLinotype TrueType WinAnsi yes yes no 152 0 OFJPKO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 155 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 180 0 OFJPKK+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 193 0 OFJPKM+PalatinoLinotype TrueType WinAnsi yes yes no 196 0 OFJPKO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 199 0 OFJPKK+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 216 0 OFJPKM+PalatinoLinotype TrueType WinAnsi yes yes no 219 0 OFJPKO+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 222 0 JBTTSN+VnURWPalladioL-Italic Type 1 Custom yes yes no 288 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 320 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:37:29 CEST RepresentationInformation: pmc_34946123.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:06:37 CEST Size: 2849495 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1318 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Microorganisms as “Villains” and Some of the Suffering They Have Caused to Humanity throughout History Destination: section.2 Children: Item: Title: Pandemics Have Weakened Empires. The First Records of Major Pandemics Destination: subsection.2.1 Item: Title: The “Black Death”, the Great Plague Pandemic of the 14th Century. The World Changes at the Huge Cost of Human Lives Destination: subsection.2.2 Children: Item: Title: Did the Plague Only Travel to Western Europe? Destination: subsubsection.2.2.1 Item: Title: How Did the Black Death Change History? Destination: subsubsection.2.2.2 Item: Title: The Plague, a Scourge Much Older Than We Thought? A Terrible Traveling Companion for Millennia Destination: subsubsection.2.2.3 Item: Title: America “Ceases to Be an Island for Plagues” and Almost Succumbs to the Arrival of Europeans. Culturization or Assimilation? Facilitated by Microorganisms Destination: subsection.2.3 Item: Title: The 1918 Flu Pandemic: “The Spanish Flu” Destination: subsection.2.4 Item: Title: Yet Another Tremendous Pandemic Disease: COVID-19, Coronavirus SARS-CoV-2, a “New Kid on the Block” Destination: subsection.2.5 Children: Item: Title: New Opportunities Are Born from All Crises Destination: subsubsection.2.5.1 Item: Title: What about the Virus? Destination: subsubsection.2.5.2 Item: Title: What Is the Origin of SARS-CoV-2? Destination: subsubsection.2.5.3 Item: Title: What Is Being Changed Directly by the Effect of SARS CoV-2? Destination: subsubsection.2.5.4 Item: Title: Microorganisms Are Not Always Enemies: Microbiota, Endogenous Viruses, and as Biotechnological Allies for Millennia Destination: section.3 Children: Item: Title: Microbiota, Our Bacterial Friends Destination: subsection.3.1 Item: Title: Endogenous Retrovirus in Human Genome: Between Disease and Evolutionary Symbiosis Destination: subsection.3.2 Item: Title: Microorganisms Helping Us Even before We Were Aware of Their Existence. Biotechnological Allies for 10,000 Years Destination: subsection.3.3 Item: Title: Can Microorganisms Structure Population Genetics? Destination: section.4 Item: Title: Final Remarks Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Microorganisms as Shapers of Human Civilization, from Pandemics to Even Our Genomes: Villains or Friends? A Historical Approach Author: Francisco Rodríguez-Frías, Josep Quer, David Tabernero, Maria Francesca Cortese, Selene Garcia-Garcia, Ariadna Rando-Segura and Tomas Pumarola Subject: Universal history is characterized by continuous evolution, in which civilizations are born and die. This evolution is associated with multiple factors, among which the role of microorganisms is often overlooked. Viruses and bacteria have written or decisively contributed to terrible episodes of history, such as the Black Death in 14th century Europe, the annihilation of pre-Columbian American civilizations, and pandemics such as the 1918 Spanish flu or the current COVID-19 pandemic caused by the coronavirus SARS-CoV-2. Nevertheless, it is clear that we could not live in a world without these tiny beings. Endogenous retroviruses have been key to our evolution and for the regulation of gene expression, and the gut microbiota helps us digest compounds that we could not otherwise process. In addition, we have used microorganisms to preserve or prepare food for millennia and more recently to obtain drugs such as antibiotics or to develop recombinant DNA technologies. Due to the enormous importance of microorganisms for our survival, they have significantly influenced the population genetics of different human groups. This paper will review the role of microorganisms as “villains” who have been responsible for tremendous mortality throughout history but also as “friends” who help us survive and evolve. 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