936b55d070a294f4005445886ca8870d pmc_34960209.pdf 3c06bbf6845e6c2858cb38fd35a931d3f6ba3cd2 pmc_34960209.pdf 94dbc59aa42f516c8809b1a908ecdcda9c29954fd810d1a91b40563f47923a12 pmc_34960209.pdf Title: Local and Systemic Adverse Reactions to mRNA COVID-19 Vaccines Comparing Two Vaccine Types and Occurrence of Previous COVID-19 Infection Subject: The aim of this study was to assess adverse reactions to COVID-19 vaccines, comparing the BNT162b2 or the mRNA-1273 COVID-19 vaccines and the presence and seriousness of a previous COVID-19 infection. We conducted a cross-sectional online survey of vaccinated healthcare workers at a tertiary hospital in Barcelona (Spain). Thirty-eight percent of vaccine recipients responded to the questionnaire. We compared the prevalence of adverse reactions by vaccine type and history of COVID-19 infections. A total of 2373 respondents had received the BNT162b2 vaccine, and 506 the mRNA-1273 vaccine. The prevalence of at least one adverse reaction with doses 1 and 2 was 41% and 70%, respectively, in the BNT162b2 group, and 60% and 92% in the mRNA-1273 group (p < 0.001). The BNT162b2 group reported less prevalence of all adverse reactions. Need for medical leave was significantly more frequent among the mRNA-1273 group (12% versus 4.6% p < 0.001). Interestingly, respondents with a history of allergies or chronic illnesses did not report more adverse reactions. The frequency of adverse reactions with dose 2 was 96% (95% CI 88–100%) for those with a history of COVID-19 related hospitalization, and 86% (95% CI 83–89%) for those with mild or moderate symptomatic COVID-19, significantly higher than for participants with no history of COVID-19 infections (67%, 95% CI 65–69%). Our results could help inform vaccine recipients of the probability of their having adverse reactions to COVID-19 vaccines. Keywords: SARS-CoV-2; COVID-19-vaccination; mRNA vaccines; adverse reactions; healthcare workers Author: Oleguer Parés-Badell, Xavier Martínez-Gómez, Laia Pinós, Blanca Borras-Bermejo, Sonia Uriona, Susana Otero-Romero, José Ángel Rodrigo-Pendás, Yolima Cossio-Gil, Antònia Agustí, Cristina Aguilera and Magda Campins Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Dec 13 03:33:05 2021 CET ModDate: Mon Dec 13 03:34:40 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1756407 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UXXAKG+VnURWPalladioL Type 1 Custom yes yes no 10 0 ARCQYN+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 PFJIRV+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 DMAUIQ+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 CPTAIT+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 55 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 59 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 63 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 78 0 ZYGMNY+CMSY10 Type 1 Builtin yes yes no 85 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 98 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:37:27 CEST RepresentationInformation: pmc_34960209.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:08:11 CEST Size: 1756407 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 240 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Local and Systemic Adverse Reactions to mRNA COVID-19 Vaccines Comparing Two Vaccine Types and Occurrence of Previous COVID-19 Infection Author: Oleguer Parés-Badell, Xavier Martínez-Gómez, Laia Pinós, Blanca Borras-Bermejo, Sonia Uriona, Susana Otero-Romero, José Ángel Rodrigo-Pendás, Yolima Cossio-Gil, Antònia Agustí, Cristina Aguilera and Magda Campins Subject: The aim of this study was to assess adverse reactions to COVID-19 vaccines, comparing the BNT162b2 or the mRNA-1273 COVID-19 vaccines and the presence and seriousness of a previous COVID-19 infection. We conducted a cross-sectional online survey of vaccinated healthcare workers at a tertiary hospital in Barcelona (Spain). Thirty-eight percent of vaccine recipients responded to the questionnaire. We compared the prevalence of adverse reactions by vaccine type and history of COVID-19 infections. A total of 2373 respondents had received the BNT162b2 vaccine, and 506 the mRNA-1273 vaccine. The prevalence of at least one adverse reaction with doses 1 and 2 was 41% and 70%, respectively, in the BNT162b2 group, and 60% and 92% in the mRNA-1273 group (p < 0.001). The BNT162b2 group reported less prevalence of all adverse reactions. Need for medical leave was significantly more frequent among the mRNA-1273 group (12% versus 4.6% p < 0.001). Interestingly, respondents with a history of allergies or chronic illnesses did not report more adverse reactions. The frequency of adverse reactions with dose 2 was 96% (95% CI 88 100%) for those with a history of COVID-19 related hospitalization, and 86% (95% CI 83 89%) for those with mild or moderate symptomatic COVID-19, significantly higher than for participants with no history of COVID-19 infections (67%, 95% CI 65 69%). Our results could help inform vaccine recipients of the probability of their having adverse reactions to COVID-19 vaccines. Keywords: SARS-CoV-2; COVID-19-vaccination; mRNA vaccines; adverse reactions; healthcare workers Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Dec 13 03:33:05 CET 2021 ModDate: Mon Dec 13 03:34:40 CET 2021 ID: 0x5516ac930548aed044678d607d4ad375, 0x5516ac930548aed044678d607d4ad375 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: OVNEXW+EURM10 FontSubset: true FirstChar: 22 LastChar: 22 FontDescriptor: FontName: OVNEXW+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: PFJIRV+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: PFJIRV+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZYGMNY+CMSY10 FontSubset: true FirstChar: 14 LastChar: 21 FontDescriptor: FontName: ZYGMNY+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: DMAUIQ+URWPalladioL-Roma FontSubset: 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