a64e7d93d601ee9f76f5372f1b9e07d6  pmc_34970706.pdf
f9eebafa48ae459cd254faa4b55af3877276e707  pmc_34970706.pdf
a02d95dec186812121362f357eb040c94ba62a717216131b51854df439924521  pmc_34970706.pdf

Title:          Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges
Subject:        Intensive Care Medicine Experimental, https://doi.org/10.1186/s40635-021-00424-5
Keywords:       Cell therapy;Mesenchymal stem cells;Pneumonia;Coronavirus;Influenza;Acute respiratory distress syndrome;Sepsis;Critical illness;Pandemic;Acute hypoxic respiratory failure
Author:          C. H. Masterson
Creator:        Adobe InDesign 15.0 (Windows)
Producer:       Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Sat Dec  4 13:14:58 2021 CET
ModDate:        Sat Dec 11 13:44:38 2021 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          21
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1192581 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     29  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     33  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     35  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     34  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     30  0
QVMCWX+OpenSans                      Type 1C           WinAnsi          yes yes no     396  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     31  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes     32  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  yes    351  0
YDKCEH+STIXMath-Regular              Type 1C           WinAnsi          yes yes yes    132  0
IMFLBC+MTSY                          Type 1C           Custom           yes yes yes    226  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    340  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-05-27 02:52:08 CEST
 RepresentationInformation: pmc_34970706.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-03-31 12:08:13 CEST
  Size: 1192581
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 489
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Mesenchymal stemstromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges
      Children: 
       Item: 
        Title: Abstract 
       Item: 
        Title: Introduction
       Item: 
        Title: Aetiology and epidemiology of severe viral pneumonia
       Item: 
        Title: Mechanisms of lung injury in viral pneumonia
       Item: 
        Title: Current therapies for viral pneumonia
       Item: 
        Title: MSCs—therapeutic potential for viral pneumonia
        Children: 
         Item: 
          Title: MSC administration kinetics
         Item: 
          Title: Microenvironmental responsiveness and MSC pre-activation
         Item: 
          Title: Direct versus indirect MSC effects
       Item: 
        Title: MSCs—insights from pre-clinical studies
        Children: 
         Item: 
          Title: MSC effects in viral pneumonia
         Item: 
          Title: Strain-dependent efficacy in influenza models
         Item: 
          Title: MSCs in pre-clinical COVID-19
         Item: 
          Title: Cell-free therapies
         Item: 
          Title: Summary
       Item: 
        Title: MSCs—insights from clinical studies
        Children: 
         Item: 
          Title: MSC safety profile in clinical trials
         Item: 
          Title: Clinical trials in ARDS and sepsis
         Item: 
          Title: MSCs in viral pneumonia
       Item: 
        Title: Future directions: opportunities and challenges
        Children: 
         Item: 
          Title: Optimal MSC therapeutic
         Item: 
          Title: Optimal MSC dosing regimen
         Item: 
          Title: Optimal patient population
         Item: 
          Title: Impairment of MSCs by viral infection
         Item: 
          Title: MSCs use with concomitant therapy
       Item: 
        Title: Summary and conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges
    Author:  C. H. Masterson
    Subject: Intensive Care Medicine Experimental, https://doi.org/10.1186/s40635-021-00424-5
    Keywords: Cell therapy;Mesenchymal stem cells;Pneumonia;Coronavirus;Influenza;Acute respiratory distress syndrome;Sepsis;Critical illness;Pandemic;Acute hypoxic respiratory failure
    Creator: Adobe InDesign 15.0 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sat Dec 04 13:14:58 CET 2021
    ModDate: Sat Dec 11 13:44:38 CET 2021
   ID: 0x7a2dcbb4f4f22c55291f9673d59ef4f1, 0x4357770f76c7c07c66b972dffef51cfb
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1418
      ImageHeight: 865
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IMFLBC+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: IMFLBC+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YDKCEH+STIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: YDKCEH+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: QVMCWX+OpenSans
      FontSubset: true
      FirstChar: 32
      LastChar: 120
      FontDescriptor: 
       FontName: QVMCWX+OpenSans
       Flags: Nonsymbolic
       FontBBox: -550, -271, 1204, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2021-12-04T12:14:58</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.0 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2021-12-11T13:44:38+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2021-12-11T13:44:38+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Cell therapy;Mesenchymal stem cells;Pneumonia;Coronavirus;Influenza;Acute respiratory distress syndrome;Sepsis;Critical illness;Pandemic;Acute hypoxic respiratory failure</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s40635-021-00424-5</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer International Publishing</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Intensive Care Medicine Experimental, https://doi.org/10.1186/s40635-021-00424-5</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Cell therapy</rdf:li>
               <rdf:li>Mesenchymal stem cells</rdf:li>
               <rdf:li>Pneumonia</rdf:li>
               <rdf:li>Coronavirus</rdf:li>
               <rdf:li>Influenza</rdf:li>
               <rdf:li>Acute respiratory distress syndrome</rdf:li>
               <rdf:li>Sepsis</rdf:li>
               <rdf:li>Critical illness</rdf:li>
               <rdf:li>Pandemic</rdf:li>
               <rdf:li>Acute hypoxic respiratory failure</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> C. H. Masterson</rdf:li>
               <rdf:li> A. Ceccato</rdf:li>
               <rdf:li> A. Artigas</rdf:li>
               <rdf:li> C. dos Santos</rdf:li>
               <rdf:li> P. R. Rocco</rdf:li>
               <rdf:li> S. Enes</rdf:li>
               <rdf:li> D. J. Weiss</rdf:li>
               <rdf:li> D. McAuley</rdf:li>
               <rdf:li> M. A. Matthay</rdf:li>
               <rdf:li> K. English</rdf:li>
               <rdf:li> G. F. Curley</rdf:li>
               <rdf:li> J. G. Laffey</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s40635-021-00424-5</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s40635-021-00424-5</prism:url>
         <prism:doi>10.1186/s40635-021-00424-5</prism:doi>
         <prism:issn>2197-425X</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Intensive Care Medicine Experimental</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s40635-021-00424-5</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:446f2ce1-701e-42d0-8265-a3dd30ec01a2</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b683153d-ebfd-4a99-a00f-cac45d09639f</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:446f2ce1-701e-42d0-8265-a3dd30ec01a2</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2021-12-04T13:27:57Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name> J. G. Laffey</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1246-9573</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 410, 566, 422, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 521, 64, 538, 56
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 178, 56, 279, 48
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 325, 661, 330, 649
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 336, 661, 341, 649
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 359, 435, 364, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 257, 393, 262, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 295, 393, 300, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 273, 350, 278, 338
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 305, 336, 309, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 212, 308, 217, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 223, 308, 228, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 230, 280, 240, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 216, 251, 226, 239
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 225, 237, 235, 225
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 321, 690, 330, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 256, 676, 266, 663
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 176, 647, 185, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 143, 577, 153, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 152, 562, 162, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 290, 548, 300, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 323, 534, 333, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 362, 492, 372, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 120, 435, 130, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 136, 435, 146, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 462, 435, 472, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 348, 421, 358, 409
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 312, 393, 322, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 326, 393, 336, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 411, 345, 421, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 254, 303, 264, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 281, 274, 291, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 309, 218, 318, 205
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 403, 161, 413, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 271, 104, 281, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 287, 104, 297, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 316, 676, 326, 663
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 354, 605, 364, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 369, 605, 379, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 338, 520, 348, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 362, 492, 372, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 263, 407, 274, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 280, 407, 290, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 273, 364, 283, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 289, 364, 299, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 229, 322, 240, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 335, 308, 345, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 451, 279, 461, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 311
      Annotation: 
       Subtype: Link
       Rect: 233, 237, 243, 225
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 249, 237, 259, 225
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 153, 194, 163, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 262, 166, 272, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 359, 138, 369, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 290, 110, 300, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 245, 81, 256, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 163, 661, 173, 649
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 415, 619, 425, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 316, 591, 320, 579
       Flags: Print
       AppearanceDictionary: true
       Destination: 93
      Annotation: 
       Subtype: Link
       Rect: 181, 548, 191, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 258, 463, 268, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 341, 435, 351, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 407, 338, 418, 329
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 426, 338, 438, 329
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 445, 338, 457, 329
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 407, 329, 418, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 407, 272, 418, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 426, 272, 438, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 407, 215, 418, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 426, 215, 438, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 445, 215, 457, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 407, 206, 418, 197
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 407, 185, 418, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 426, 185, 438, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 407, 155, 418, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 426, 155, 438, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 445, 155, 457, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 407, 146, 418, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 426, 146, 434, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 441, 146, 453, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 407, 106, 418, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 426, 106, 438, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 445, 106, 457, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 464, 106, 472, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 407, 97, 418, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 426, 97, 434, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 167, 690, 177, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 260, 676, 270, 663
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 276, 676, 286, 663
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 420, 661, 430, 649
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 233, 605, 242, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 144, 577, 154, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 160, 577, 169, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 332, 577, 342, 564
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 384, 562, 393, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 433, 506, 443, 494
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 324, 477, 329, 465
       Flags: Print
       AppearanceDictionary: true
       Destination: 294
      Annotation: 
       Subtype: Link
       Rect: 372, 435, 382, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 388, 435, 397, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 171, 364, 181, 352
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 138, 270, 143, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 166
      Annotation: 
       Subtype: Link
       Rect: 153, 270, 158, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 223, 227, 233, 215
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 390, 161, 399, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 120, 104, 130, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 316
      Annotation: 
       Subtype: Link
       Rect: 135, 104, 145, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 161, 76, 171, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 177, 76, 187, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 312, 308, 322, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 280, 224, 290, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 248, 209, 259, 197
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 395, 195, 400, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 405, 195, 415, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 421, 195, 431, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 158, 153, 168, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 407, 139, 417, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 368, 110, 378, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 441, 676, 451, 664
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 298, 648, 308, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 331, 619, 336, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 232, 577, 242, 565
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 248, 577, 258, 565
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 449, 549, 459, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 414, 506, 425, 494
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 429, 506, 439, 494
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 444, 506, 454, 494
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 152, 464, 162, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 167, 464, 177, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 387, 464, 397, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 461, 418, 472, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 173, 390, 183, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 446, 390, 456, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 461, 390, 472, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 265, 333, 275, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 280, 333, 290, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 417, 246, 427, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 146, 217, 156, 205
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 279, 690, 290, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 385, 661, 400, 649
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 352, 605, 367, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 210, 520, 225, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 409, 294, 423, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 180, 237, 194, 225
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 457, 138, 472, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 373, 81, 387, 63
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 358, 633, 373, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 333, 591, 348, 579
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 295, 462, 310, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 316, 462, 331, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 152, 391, 167, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 254, 203, 269, 191
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 370, 690, 385, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 398, 676, 408, 663
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 414, 676, 430, 663
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 206, 647, 221, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 303, 633, 318, 621
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 298, 605, 313, 593
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 148, 522, 164, 503
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 381, 423, 386, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
      Annotation: 
       Subtype: Link
       Rect: 124, 380, 139, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 145, 380, 160, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 223, 366, 238, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 427, 263, 438, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 442, 233, 453, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 438, 185, 450, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 406, 538, 411, 525
       Flags: Print
       AppearanceDictionary: true
       Destination: 259
      Annotation: 
       Subtype: Link
       Rect: 188, 401, 203, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 208, 401, 223, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 141, 387, 156, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 205, 331, 220, 318
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 282, 288, 297, 276
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 431, 138, 445, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 160, 95, 175, 83
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 303, 81, 318, 69
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 168, 704, 182, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 356, 704, 371, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 376, 704, 391, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 216, 690, 298, 678
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 120, 647, 135, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 457, 647, 472, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 323
      Annotation: 
       Subtype: Link
       Rect: 246, 506, 261, 494
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 187, 291, 202, 279
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 208, 291, 222, 279
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 457, 291, 472, 279
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 120, 220, 135, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 306, 164, 321, 151
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 222, 76, 237, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
     Thumb: true
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 278, 690, 293, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 349, 550, 364, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 329
      Annotation: 
       Subtype: Link
       Rect: 309, 301, 441, 292
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 15
     Thumb: true
    Page: 
     Sequence: 16
     Thumb: true
    Page: 
     Sequence: 17
     Thumb: true
    Page: 
     Sequence: 18
     Thumb: true
    Page: 
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 324, 289, 456, 280
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 20
     Thumb: true
    Page: 
     Sequence: 21
     Thumb: true
  Checksum: b6d4dbf5
   Type: CRC32
  Checksum: a64e7d93d601ee9f76f5372f1b9e07d6
   Type: MD5
  Checksum: f9eebafa48ae459cd254faa4b55af3877276e707
   Type: SHA-1