568470e00b662efc4eef0b4abd1893a8 pmc_35003125.pdf 15caaf1321c1d536c8723c62ebab9e84457eefec pmc_35003125.pdf 3342dd31140b8e687456aacfb3e8879a98d0fa0cc299606451b0f2f29cb1ad7c pmc_35003125.pdf Title: Dual Host and Pathogen RNA-Seq Analysis Unravels Chicken Genes Potentially Involved in Resistance to Highly Pathogenic Avian Influenza Virus Infection Subject: Highly pathogenic avian influenza viruses (HPAIVs) cause severe systemic disease and high mortality rates in chickens, leading to a huge economic impact in the poultry sector Keywords: chicken, avian influenza, innate immune response, genetic resistance, RNA-Seq, PLAU Author: Albert Perlas Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Dec 17 09:11:38 2021 CET ModDate: Fri Dec 17 09:52:42 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3922894 bytes 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Classification of Chickens as Resistant and Susceptible Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.3 Host Transcriptome Analysis (RNA-Seq) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: 2.3.1 RNA Preparation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.3.2 Library Preparation and Sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.3.3 Bioinformatics Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.3.4 Enrichment Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.3.5 Validation by Quantitative PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.4 Viral Quasi-Species Comparison Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: 2.4.1 Sample Selection, Egg Passage Validation and Viral Quasi-Species Construction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.4.2 Analysis of Molecular Variance (AMOVA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: 3.1 Minor Transcriptomic Changes in Tissues From Chickens That Are Resistant to HPAIV Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 3.2 Low Viral Replication in Chickens That Are Resistant to HPAIV Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 3.3 Downregulation of the Serine Protease Encoding Gene PLAU in Lungs Correlates With Resistance to HPAIV Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 3.4 AMOVA Results Point to Few Quasi-Species Differences Between Inocula and 3 dpi Oral Swabs of Susceptible H5N8 or H7N1 Inoc甀氀愀琀攀搀 䌀栀椀挀欀攀渀猩㸾൥湤潢樍㜴㈠〠潢樼㰯䙩牳琠㜴㌠〠刯偡牥湴‷㈹‰⁒⽎數琠㜳㤠〠刯䑥獴⣾＀猀㈩⽃潵湴‱ㄯ䱡獴‷㐴‰⁒⽐牥瘠㜳〠〠刯呩瑬攨2 Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Info: Title: Dual Host and Pathogen RNA-Seq Analysis Unravels Chicken Genes Potentially Involved in Resistance to Highly Pathogenic Avian Influenza Virus Infection Author: Albert Perlas Subject: Highly pathogenic avian influenza viruses (HPAIVs) cause severe systemic disease and high mortality rates in chickens, leading to a huge economic impact in the poultry sector Keywords: chicken, avian influenza, innate immune response, genetic resistance, RNA-Seq, PLAU Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Dec 17 09:11:38 CET 2021 ModDate: Fri Dec 17 09:52:42 CET 2021 ID: 0xe11fc52e79339dee7409778e367eac93, 0xd5a630eeb612af4aa8aeee508862d022 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: 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2021-12-17T16:11:38+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2021-12-17T16:52:42+08:00 application/pdf Dual Host and Pathogen RNA-Seq Analysis Unravels Chicken Genes Potentially Involved in Resistance to Highly Pathogenic Avian Influenza Virus Infection Albert Perlas Jordi Argilaguet Kateri Bertran Ra&uacute l Sánchez-González Miquel Nofrar&iacute as Rosa Valle Antonio Ramis Mart&iacute Cortey Nat&agrave lia Maj&oacute Highly pathogenic avian influenza viruses (HPAIVs) cause severe systemic disease and high mortality rates in chickens, leading to a huge economic impact in the poultry sector chicken avian influenza innate immune response genetic resistance RNA-Seq PLAU uuid:ee06b7f2-7355-4823-8f1c-d11c90c9bb0a uuid:42496c3c-18b6-4e50-b3a7-d3ab50c42d5e Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 598, 424, 619 Annotation: Subtype: Link Rect: 175, 575, 455, 596 Annotation: Subtype: Link Rect: 175, 552, 531, 573 Annotation: Subtype: Link Rect: 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