7c83db2cc53e6786c5aecce7a893d8b2 pmc_35052582.pdf 1028b2e17b54c1a34c2063b1c44269ae952528e0 pmc_35052582.pdf 07c022b5bb120df1a7e33acbc254cca3d3d4253cd1c68bb73432e630149f5609 pmc_35052582.pdf Title: Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome Subject: The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role of extracellular vesicles in human cardiorenal syndrome development and their possible role as biomarkers, targets, or vehicles of drugs to treat this syndrome. Keywords: aging; oxidative stress; senescence; extracellular vesicles; senolytics; inflammation; age-related pathologies; oxi-inflamm-aging Author: Cristina Mas-Bargues, Matilde Alique, María Teresa Barrús-Ortiz, Consuelo Borrás and Raquel Rodrigues-Díez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Dec 30 03:22:05 2021 CET ModDate: Thu Dec 30 03:26:48 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 29 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1438271 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JGBJTI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 VGOJYJ+VnURWPalladioL Type 1 Custom yes yes no 15 0 VXIKRW+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 FHMVRN+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 XKDKTN+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 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Paradigm of Age-Related Chronic Diseases: Cardiorenal Syndrome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Age-Related Changes in Renal and Cardiovascular System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Cellular Senescence in Cardiovascular and Renal Aging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Inflammation in Cardiovascular and Renal Aging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Oxidative Stress in Cardiovascular and Renal Aging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Extracellular Vesicles in Cardiovascular and Renal Aging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Unraveling Underlying Mechanisms: Therapeutical Approaches Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Children: Item: Title: Senolytics, Senomorphics, and Senostatics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Antioxidants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Extracellular Vesicles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Children: Item: Title: Extracellular Vesicles in Clinical Prognosis/Diagnosis as a Biomarker Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Extracellular Vesicles as a Therapeutic Target (Therapeutical Approach) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Extracellular Vesicles as a Therapeutic Tool Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Beneficial and Preventive Effects of Physical Activity and Diet in Cardiovascular and Renal Diseases Mediated by EVs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Info: Title: Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome Author: Cristina Mas-Bargues, Matilde Alique, María Teresa Barrús-Ortiz, Consuelo Borrás and Raquel Rodrigues-Díez Subject: The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role of extracellular vesicles in human cardiorenal syndrome development and their possible role as biomarkers, targets, or vehicles of drugs to treat this syndrome. 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