d44ff1bd63d59ba80bb8ad5394c2d4ec The_early-life_exposome_and_epigenetic_age_acceleration_in_children.pdf 2d1a95e103943a118999d270eff08107d784555e The_early-life_exposome_and_epigenetic_age_acceleration_in_children.pdf ac5e3f08c4c07adb2ba8c7c360c1a4ed48edba977001ced52dd6b1d92ef50762 The_early-life_exposome_and_epigenetic_age_acceleration_in_children.pdf Title: The early-life exposome and epigenetic age acceleration in children Subject: Environment International, 155 (2021) 106683. doi:10.1016/j.envint.2021.106683 Keywords: Aging,Epigenetic age acceleration,Pregnancy,Childhood,Environmental exposures Author: Paula de Prado-Bert Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Jul 16 16:22:10 2021 CEST ModDate: Fri Jul 16 16:25:58 2021 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1690774 bytes Optimized: yes 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mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Study population Destination: mk:H2_1 Item: Title: 2.2 Exposome assessment during prenatal and early childhood Destination: mk:H2_2 Item: Title: 2.3 Methylation data collection Destination: mk:H2_3 Item: Title: 2.4 Calculation of epigenetic age with different clocks Destination: mk:H2_4 Item: Title: 2.5 Gene expression data collection Destination: mk:H2_5 Item: Title: 2.6 Covariates Destination: mk:H2_6 Item: Title: 2.7 Statistical analyses Destination: mk:H2_7 Children: Item: Title: 2.7.1 Descriptive analyses and correlations Destination: mk:H3_8 Item: Title: 2.7.2 Exposome-wide association study of epigenetic age acceleration Destination: mk:H3_9 Item: Title: 2.7.3 Additional insights on main exposure   epigenetic age acceleration associations Destination: mk:H3_10 Item: Title: 2.7.4 Sensitivity analyses Destination: mk:H3_11 Item: Title: 2.7.5 Expression quantitative trait methylation (eQTM) Destination: mk:H3_12 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Study population Destination: mk:H2_13 Item: Title: 3.2 Selection of the best epigenetic clock for children Destination: mk:H2_14 Item: Title: 3.3 Exposome-wide association study (ExWAS) Destination: mk:H2_15 Item: Title: 3.4 Additional insights on main exposure   epigenetic age acceleration associations Destination: mk:H2_16 Item: Title: 3.5 Sensitivity analyses Destination: mk:H2_17 Item: Title: 3.6 eQTM analyses Destination: mk:H2_18 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: 5 Conclusions Destination: mk:H1_5 Item: Title: Declaration of Competing Interest Destination: creditlink2 Item: Title: Acknowledgments Destination: mk:H1_6 Item: Title: Author’s contributions Destination: mk:H1_7 Item: Title: Appendix A Supplementary material Destination: mk:H1_8 Item: Title: References Destination: mk:HH2_1 Info: Title: The early-life exposome and epigenetic age acceleration in 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