002e79ee9b31bdb09f92b922c93c87ad pmc_33401779.pdf 11368e2d2dfd77077862f7b272b22506240c143f pmc_33401779.pdf 45afaa93980c09db2c1adeaa8553024c81b2bead8393a4cb4e7328c6a704e08e pmc_33401779.pdf Title: GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice Subject: The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field. Keywords: acromegaly; myopathy; review; growth hormone; IGF-1 Author: Betina Biagetti and Rafael Simó Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jan 8 07:11:10 2021 CET ModDate: Fri Jan 8 07:31:08 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2340898 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TKSESV+URWPalladioL-Ital Type 1 Custom yes yes no 10 0 DKDMJW+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 XRJAKH+URWPalladioL-Roma Type 1 Custom yes yes no 19 0 SOZKOC+VnURWPalladioL-Bold Type 1 Custom yes yes no 23 0 YQBMHM+VnURWPalladioL Type 1 Custom yes yes no 28 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 36 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes 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Intracellular Signalling Destination: subsection.2.2 Item: Title: The Skeletal Muscle: A Central Link between Structural and Metabolic Function Destination: section.3 Item: Title: GH/IGF-1 Actions in the Muscular System Destination: section.4 Children: Item: Title: GH Destination: subsection.4.1 Item: Title: IGF-1 Destination: subsection.4.2 Item: Title: The Key of mTOR in Muscle Structural and Metabolic Function Destination: section.5 Item: Title: Impact of GH/IGF-1 Axis Impairment on Muscle Metabolism and Function: Lessons from Basic Research Destination: section.6 Children: Item: Title: Primary Cell Cultures Destination: subsection.6.1 Item: Title: Transgenic Mice Destination: subsection.6.2 Item: Title: Experimental Research Focused on the GH/IGF-1 System Effects on Muscle Destination: subsection.6.3 Item: Title: The Muscle in GH/IGF1 Axis Deficiency Destination: section.7 Item: Title: Muscle Impairment in Human Acromegaly Destination: section.8 Item: Title: Concluding Remarks and Future Perspectives Destination: section.9 Item: Title: References Destination: section.9 Info: Title: GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice Author: Betina Biagetti and Rafael Simó Subject: The impairment of skeletal muscle function is one of the most debilitating least understood co-morbidity that accompanies acromegaly (ACRO). Despite being one of the major determinants of these patients’ poor quality of life, there is limited evidence related to the underlying mechanisms and treatment options. Although growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels are associated, albeit not indisputable, with the presence and severity of ACRO myopathies the precise effects attributed to increased GH or IGF-1 levels are still unclear. Yet, cell lines and animal models can help us bridge these gaps. This review aims to describe the evidence regarding the role of GH and IGF-1 in muscle anabolism, from the basic to the clinical setting with special emphasis on ACRO. We also pinpoint future perspectives and research lines that should be considered for improving our knowledge in the field. 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387, 515, 398 Annotation: Subtype: Link Rect: 521, 387, 557, 398 Checksum: d04e421d Type: CRC32 Checksum: 002e79ee9b31bdb09f92b922c93c87ad Type: MD5 Checksum: 11368e2d2dfd77077862f7b272b22506240c143f Type: SHA-1 Checksum: 45afaa93980c09db2c1adeaa8553024c81b2bead8393a4cb4e7328c6a704e08e Type: SHA-256