60631300a30ad10910f3af4a135f6717 pmc_33477268.pdf f981d71cd2a0de0c881eaf7e95200f003c1f1008 pmc_33477268.pdf 945a290921a1b9940f90006dc4297b58085b35dd17166261c96e7079dfb30291 pmc_33477268.pdf Title: Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection Subject: Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26–2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26–4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding. Keywords: COVID-19; SARS-CoV-2; coronavirus; heart failure; prognosis; biomarkers; NT-proBNP;troponin Author: Laia C. Belarte-Tornero, Sandra Valdivielso-Moré, Miren Vicente Elcano, Eduard Solé-González, Sonia Ruíz-Bustillo, Alicia Calvo-Fernández, Isaac Subinara, Paula Cabero, Cristina Soler, Héctor Cubero-Gallego, Beatriz Vaquerizo and Núria Farré Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun Jan 17 08:55:54 2021 CET ModDate: Sun Jan 17 09:00:49 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1532536 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- APYOUV+URWPalladioL-Ital Type 1 Custom yes yes no 10 0 KYQWSB+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 PXHVKW+URWPalladioL-Roma Type 1 Custom yes yes no 19 0 OSMCID+VnURWPalladioL-Bold Type 1 Custom yes yes no 23 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 32 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 35 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 57 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 61 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 65 0 TNBSFT+CMSY10 Type 1 Builtin yes yes no 77 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 84 0 DFJMHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 94 0 DFJMIA+PalatinoLinotype TrueType WinAnsi yes yes no 97 0 DFJMIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 100 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 107 0 DFJMHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 120 0 DFJMHP+PalatinoLinotype CID TrueType Identity-H yes yes yes 123 0 DFJMIA+PalatinoLinotype TrueType WinAnsi yes yes no 129 0 DFJMIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 132 0 DFJNGP+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 135 0 DFJMHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 148 0 DFJMHP+PalatinoLinotype CID TrueType Identity-H yes yes yes 151 0 DFJMIA+PalatinoLinotype TrueType WinAnsi yes yes no 157 0 DFJMIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 160 0 DFJNGP+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 163 0 DFJMHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 170 0 DFJMIA+PalatinoLinotype TrueType WinAnsi yes yes no 173 0 DFJMIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 176 0 VYLLMY+VnURWPalladioL Type 1 Custom yes yes no 183 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 197 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-21 02:39:47 CEST RepresentationInformation: pmc_33477268.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:08:37 CEST Size: 1532536 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 374 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Study Design and Data Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Ethics Considerations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Children: Item: Title: Characteristics of Chronic Heart Failure (CHF) versus Non-CHF Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Outcomes in CHF vs. Non-CHF Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: CHF Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Info: Title: Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection Author: Laia C. Belarte-Tornero, Sandra Valdivielso-Moré, Miren Vicente Elcano, Eduard Solé-González, Sonia Ruíz-Bustillo, Alicia Calvo-Fernández, Isaac Subinara, Paula Cabero, Cristina Soler, Héctor Cubero-Gallego, Beatriz Vaquerizo and Núria Farré Subject: Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting. Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored. Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26 2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF. Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26 4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding. 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