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Title:           Chronic exposure to IL-6 induces a desensitized phenotype of the microglia
Subject:         Journal of Neuroinflammation, 2021, doi:10.1186/s12974-020-02063-1
Keywords:        Axonal sprouting,Primed microglia,T cell,Monocyte,MHCII
Author:          Mireia Recasens
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     Item: 
      Title: Abstract
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      Children: 
       Item: 
        Title: Background
        Destination: sectionASec1
       Item: 
        Title: Methods
        Destination: sectionASec2
       Item: 
        Title: Results
        Destination: sectionASec3
       Item: 
        Title: Conclusions
        Destination: sectionASec4
     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Materials and methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Animals
        Destination: sectionSec3
       Item: 
        Title: Perforant pathway transection and experimental groups
        Destination: sectionSec4
       Item: 
        Title: 5′ Bromodeoxyuridine injections
        Destination: sectionSec5
       Item: 
        Title: Tissue processing for histological analysis
        Destination: sectionSec6
       Item: 
        Title: Toluidine blue staining
        Destination: sectionSec7
       Item: 
        Title: Single stain immunohistochemistry
        Destination: sectionSec8
       Item: 
        Title: Double stain immunohistochemistry
        Destination: sectionSec9
       Item: 
        Title: Terminal dUTP nick end labeling
        Destination: sectionSec10
       Item: 
        Title: Sulfide-silver staining
        Destination: sectionSec11
       Item: 
        Title: Brightfield microscopy densitometric analysis
        Destination: sectionSec12
       Item: 
        Title: Morphometric analysis
        Destination: sectionSec13
       Item: 
        Title: Flow cytometry analysis
        Destination: sectionSec14
       Item: 
        Title: Tissue processing for protein analysis
        Destination: sectionSec15
       Item: 
        Title: Cytokine analysis
        Destination: sectionSec16
       Item: 
        Title: Tissue processing for serum samples
        Destination: sectionSec17
       Item: 
        Title: IL-6 ELISA
        Destination: sectionSec18
       Item: 
        Title: Statistical analysis
        Destination: sectionSec19
     Item: 
      Title: Results
      Destination: sectionSec20
      Children: 
       Item: 
        Title: Astrocyte-targeted IL-6 production modifies the number and morphology of microglia/macrophage cell populations
        Destination: sectionSec21
        Children: 
         Item: 
          Title: Analysis of microglia/macrophage cell distribution and morphology
          Destination: sectionSec22
         Item: 
          Title: Analysis of microglia/macrophage cell density
          Destination: sectionSec23
       Item: 
        Title: Astrocyte-targeted IL-6 production increases microglial cell proliferation after PPT but has no effects on cell death
        Destination: sectionSec24
       Item: 
        Title: Astrocyte-targeted IL-6 production increases the number of monocytes/macrophages
        Destination: sectionSec25
       Item: 
        Title: Astrocyte-targeted IL-6 production modifies the phenotype of CD11b+/CD45high cell population
        Destination: sectionSec26
       Item: 
        Title: Astrocyte-targeted IL-6 production promotes T cell infiltration after PPT
        Destination: sectionSec27
       Item: 
        Title: Absence of T cell co-stimulatory molecules after PPT
        Destination: sectionSec28
       Item: 
        Title: Astrocyte-targeted IL-6 production induces alterations in the cytokine/chemokine microenvironment after PPT
        Destination: sectionSec29
       Item: 
        Title: Astrocyte-targeted IL-6 production reduces collateral sprouting after PPT
        Destination: sectionSec30
     Item: 
      Title: Discussion
      Destination: sectionSec31
      Children: 
       Item: 
        Title: Astrocyte-targeted production of IL-6 induces alterations in the microglia/macrophage, lymphocyte, and cytokine/chemokine microenvironment
        Destination: sectionSec32
       Item: 
        Title: Increased microglia/macrophage in GFAP-IL6Tg mice after PPT might be due to both proliferation and recruitment of bone-marrow derived monocytes
        Destination: sectionSec33
       Item: 
        Title: After PPT, astrocyte-targeted production of IL-6 promoted a shift in the phenotype of CD11b+/CD45high cells and avoided the transformation of any parenchymal microglia into putative MHCII+ antigen presenting cells
        Destination: sectionSec34
       Item: 
        Title: Astrocyte-targeted production of IL-6 increased lymphocyte recruitment after PPT without modifying their differentiation
        Destination: sectionSec35
       Item: 
        Title: Astrocyte-targeted production of IL-6 promoted alterations in the cytokine/chemokine profile associated with PPT
        Destination: sectionSec36
       Item: 
        Title: Astrocyte-targeted production of IL-6 reduced axonal sprouting
        Destination: sectionSec37
     Item: 
      Title: Conclusions
      Destination: sectionSec38
     Item: 
      Title: Supplementary Information
      Destination: sectionSec39
     Item: 
      Title: Abbreviations
      Destination: sectionabr1
     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
      Destination: section4
     Item: 
      Title: Ethics approval and consent to participate
      Destination: sectionFPar1
     Item: 
      Title: Consent for publication
      Destination: sectionFPar2
     Item: 
      Title: Competing interests
      Destination: sectionFPar3
     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
      Destination: sectionBib1
     Item: 
      Title: Publisher’s Note
      Destination: ArtNote1
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    Title: Chronic exposure to IL-6 induces a desensitized phenotype of the microglia
    Author: Mireia Recasens
    Subject: Journal of Neuroinflammation, 2021, doi:10.1186/s12974-020-02063-1
    Keywords: Axonal sprouting,Primed microglia,T cell,Monocyte,MHCII
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                           <pdfaProperty:valueType>Bag SeriesEditorInformation</pdfaProperty:valueType>
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                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
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                                    <pdfaField:valueType>URI</pdfaField:valueType>
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                           <pdfaType:type>EditorInformation</pdfaType:type>
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                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
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                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
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                                    <pdfaField:valueType>URI</pdfaField:valueType>
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                           <pdfaType:description>Specifies the types of series editor information: name and ORCID of a series editor.</pdfaType:description>
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                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
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                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
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                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
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