bb54e8d66a524417811d46c9c57deef7 pmc_33482914.pdf 7f4284573d308c8fdb8b60b1359833c3cd72066d pmc_33482914.pdf 83739bfef124bfdab584b635378b58efc01558423301a187957774e3f086cea4 pmc_33482914.pdf Title: Activation of regulated cell death in the lung of piglets infected with virulent PRRSV-1 Lena strain occurs earlier and mediated by cleaved Caspase-8 Subject: Veterinary Research, https://doi.org/10.1186/s13567-020-00882-x Keywords: PRRSV-1,virulent strain,regulated cell death,lung,cleaved caspase-8 Author: Jose María Sánchez-Carvajal Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Jan 20 02:39:48 2021 CET ModDate: Fri Jan 22 06:41:04 2021 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 7957061 bytes Optimized: no PDF version: 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yes no 534 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:34:10 CEST RepresentationInformation: pmc_33482914.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:08:39 CEST Size: 7957061 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 694 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Activation of regulated cell death in the lung of piglets infected with virulent PRRSV-1 Lena strain occurs earlier and mediated by cleaved Caspase-8 Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Material and methods Children: Item: Title: Animals and experimental design Item: Title: PRRSV lung viral load Item: Title: Histopathology of lung tissue Item: Title: Immunohistochemistry assays Item: Title: Statistical analyses Item: Title: Results Children: Item: Title: Lena-infected pigs displayed severe lung lesions compared to 3249-infected pigs Item: Title: Lung viral load was higher in Lena-infected pigs Item: Title: Lena-infected pigs presented the highest number of PRRSV-N-protein+ cells and the lowest number of CD163+ cells Item: Title: TUNEL labelling was highly expressed in the lung of Lena-infected animals Item: Title: Casp3 followed a similar kinetics in Lena- and 3249-infected groups, being more intense for Lena group Item: Title: A positive correlation between the frequency of cCasp8+ cells and cCasp9+ cells was observed in both PRRSV-1 infected groups Item: Title: Discussion Item: Title: Acknowledgements Item: Title: References Info: Title: Activation of regulated cell death in the lung of piglets 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5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) PRRSV-1,virulent strain,regulated cell death,lung,cleaved caspase-8 application/pdf https://doi.org/10.1186/s13567-020-00882-x BioMed Central Veterinary Research, https://doi.org/10.1186/s13567-020-00882-x PRRSV-1 virulent strain regulated cell death lung cleaved caspase-8 Activation of regulated cell death in the lung of piglets infected with virulent PRRSV-1 Lena strain occurs earlier and mediated by cleaved Caspase-8 Jose María Sánchez-Carvajal Inés Ruedas-Torres Librado Carrasco Francisco José Pallarés Enric Mateu Irene Magdalena Rodríguez-Gómez Jaime Gómez-Laguna 10.1186/s13567-020-00882-x 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s13567-020-00882-x 10.1186/s13567-020-00882-x 1297-9716 journal Veterinary Research The Author(s) 2010-04-23 true 10.1186/s13567-020-00882-x noindex springer.com springerlink.com VoR uuid:c7709b37-9495-4502-8ef5-59b407331051 uuid:c020d48f-f3f3-4d29-a822-b7ec76698e75 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