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Title:           Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
Subject:         
Keywords:        
Author:          
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      Title: Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
      Destination: chapter..1
      Children: 
       Item: 
        Title: Abstract
        Destination: section*.2
       Item: 
        Title: 1 | INTRODUCTION
        Destination: section..1.1
       Item: 
        Title: 2 | RESULTS
        Destination: section..1.2
        Children: 
         Item: 
          Title: 2.1 | Increased frequency of the SIGLEC1 null allele in individuals with extrapulmonary/disseminated TB from an HIV-1 Cohort
          Destination: subsection..1.2.1
         Item: 
          Title: 2.2 | An increased frequency of the SIGLEC1 null allele in individuals with extrapulmonary/disseminated TB is also confirmed in a TB cohort
          Destination: subsection..1.2.2
         Item: 
          Title: 2.3 | Mtb local dissemination in infected SIGLEC1 knockout mice aggravates pulmonary lesions
          Destination: subsection..1.2.3
         Item: 
          Title: 2.4 | Siglec-1 is not involved in Mtb capture and clearance
          Destination: subsection..1.2.4
         Item: 
          Title: 2.5 | Siglec-1 on antigen-presenting cells is required to induce antigen presentation via extracellular vesicle uptake
          Destination: subsection..1.2.5
       Item: 
        Title: 3 | DISCUSSION
        Destination: section..1.3
       Item: 
        Title: 4 | MATERIALS & METHODS
        Destination: section..1.4
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         Item: 
          Title: 4.1 | Ethics statement
          Destination: subsection..1.4.1
         Item: 
          Title: 4.2 | Study cohorts
          Destination: subsection..1.4.2
         Item: 
          Title: 4.3 | SIGLEC-1 genetic analyses
          Destination: subsection..1.4.3
         Item: 
          Title: 4.4 | Mice and Mtb infection
          Destination: subsection..1.4.4
         Item: 
          Title: 4.5 | Murine histopathological analysis
          Destination: subsection..1.4.5
         Item: 
          Title: 4.6 | Murine bacillary load measurement
          Destination: subsection..1.4.6
         Item: 
          Title: 4.7 | Murine cytokine profiling
          Destination: subsection..1.4.7
         Item: 
          Title: 4.8 | Siglec-1 siRNA silencing in monocyte-derived macrophages, Mtb infection and CFU enumeration
          Destination: subsection..1.4.8
         Item: 
          Title: 4.9 | Detection of sialylated residues on Mtb cell lysates
          Destination: subsection..1.4.9
         Item: 
          Title: 4.10 | Mtb infection of THP-1-derived human macrophages
          Destination: subsection..1.4.10
         Item: 
          Title: 4.11 | Extracellular vesicle isolation and purification
          Destination: subsection..1.4.11
         Item: 
          Title: 4.12 | Size and morphological analysis of extracellular vesicles
          Destination: subsection..1.4.12
         Item: 
          Title: 4.13 | Uptake assays of fluorescent extracellular vesicles
          Destination: subsection..1.4.13
         Item: 
          Title: 4.14 | IFN- ELISpot assay
          Destination: subsection..1.4.14
         Item: 
          Title: 4.15 | Statistical analyses
          Destination: subsection..1.4.15
       Item: 
        Title: ACKNOWLEDGEMENTS
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       Item: 
        Title: FINANCIAL SUPPORT
        Destination: section*.6
       Item: 
        Title: CONFLICT OF INTEREST
        Destination: section*.8
       Item: 
        Title: AUTHOR CONTRIBUTION
        Destination: section*.10
        Children: 
         Item: 
          Title: DATA AVAILABILITY STATEMENT
          Destination: section*.12
       Item: 
        Title: ORCID
        Destination: section*.14
       Item: 
        Title: REFERENCES
        Destination: section*.16
       Item: 
        Title: SUPPORTING INFORMATION
        Destination: section*.18
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