dc1964da3a3d98b741cce40299e82403 pmc_33495439.pdf 17e2c0524954486af14b5f38ee8728aa9fb79e30 pmc_33495439.pdf 4e9195e0ada7572c2d45dfb1e3cf4fbb9e03eafc0aab2059a33a8da300eda6c9 pmc_33495439.pdf Title: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder Subject: Nature Communications, doi:10.1038/s41467-020-20443-2 Keywords: Author: Ditte Demontis Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Jan 18 18:05:16 2021 CET ModDate: Tue Jan 19 16:53:54 2021 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1067954 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LBIAKK+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 103 0 LBIAJI+Arial-BoldMT Type 1C WinAnsi yes yes no 161 0 LBIAJJ+AdvOTf23bb480 Type 1C WinAnsi yes yes no 465 0 LBIAJK+AdvOTf23bb480+fb Type 1C Custom yes yes yes 813 0 LBHOFA+AdvOTea1a7398 Type 1C WinAnsi yes yes no 105 0 LBHOKO+AdvOTea1a7398+fb Type 1C Custom yes yes yes 133 0 LBHONO+AdvTT2876772e+27 Type 1C Custom yes yes yes 467 0 LBIAHF+AdvTTab7e17fd Type 1C WinAnsi yes yes no 110 0 LBIAHG+AdvTTab7e17fd+22 Type 1C Custom yes yes no 112 0 LBIAHH+AdvOTcb88df00 Type 1C WinAnsi yes yes no 114 0 LBIAML+AdvOT125c650c Type 1C WinAnsi yes yes no 104 0 LBIANP+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 106 0 LBIAPA+AdvOT7d6df7ab.I+03 Type 1C Custom yes yes yes 107 0 LBIAMO+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 108 0 LBIANO+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 109 0 LBIAMM+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 111 0 LBIAMN+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 113 0 LBIBAC+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 130 0 LBIBAA+AdvOTcb88df00+fb Type 1C Custom yes yes yes 131 0 LBIBAB+AdvOTe75a9404.I Type 1C WinAnsi yes yes no 132 0 LBIDCG+AdvOTcb88df00+20 Type 1C WinAnsi yes yes no 160 0 LBIDCH+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 162 0 LBIDEI+ArialMT Type 1C Custom yes yes no 163 0 LBIDLG+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 298 0 LBIDNI+AdvP4C4E51 Type 1C WinAnsi yes yes no 375 0 LBIDOJ+AdvP4C4E46 Type 1C Custom yes yes no 376 0 LBIDMH+AdvP4C4E59 Type 1C WinAnsi yes yes no 377 0 LBIDNH+AdvP4C4E74 Type 1C Custom yes yes yes 378 0 LBIEEI+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 443 0 LBIEHH+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 466 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 02:49:41 CEST RepresentationInformation: pmc_33495439.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:08:40 CEST Size: 1067954 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bm_CR73' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR74' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR75' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR76' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR77' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR78' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR79' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR80' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR81' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR82' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR83' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR80' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR84' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR85' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR86' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR87' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR88' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR85' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR89' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR80' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 476355 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR90' cannot be found Offset: 476355 ID: PDF-HUL-129 InfoMessage: Outlines contain recursive references. MIMEtype: application/pdf PDFMetadata: Objects: 948 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Genetic correlation with aggression-related phenotypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Genetic correlation with aggression-related phenotypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Samples—the iPSYCH cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Samples—cohorts from the Psychiatric Genomics Consortium Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Quality control and imputation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: GWAS meta-analysis and transancestry risk in European and Chinese ethnicities Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Homogeneity of effects in the PGC and iPSYCH cohorts and intercept evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Secondary GWASs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Gene-based association test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Gene-based association test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Code availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: Risk variants and polygenic architecture of disruptive behavior disorders in 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attention-deficit/hyperactivity disorder Ditte Demontis Raymond K. Walters Veera M. Rajagopal Irwin D. Waldman Jakob Grove Thomas D. Als Søren Dalsgaard Marta Ribasas Jonas Bybjerg-Grauholm Maria Bækvad-Hansen Thomas Werge Merete Nordentoft Ole Mors Preben Bo Mortensen Ole A. Andreassen Maria Jesús Arranz Tobias Banaschewski Claiton Bau Mark Bellgrove Joseph Biederman Isabell Brikell Jan K. Buitelaar Christie L. Burton Miguel Casas Jennifer Crosbie Alysa E. Doyle Richard P. Ebstein Josephine Elia Corfield C. Elizabeth Eugenio Grevet Natalie Grizenko Alexandra Havdahl Ziarih Hawi Johannes Hebebrand Amaia Hervas Sarah Hohmann Jan Haavik Ridha Joober Lindsey Kent Jonna Kuntsi Kate Langley Henrik Larsson Klaus-Peter Lesch Patrick W. L. Leung Calwing Liao Sandra K. Loo Joanna Martin Nicholas G. Martin Sarah E. Medland Ana Miranda Nina Roth Mota Robert D. Oades Josep Antoni Ramos-Quiroga Andreas Reif Marcella Rietschel Herbert Roeyers Luis Augusto Rohde Aribert Rothenberger Paula Rovira Cristina Sánchez-Mora Russell James Schachar Sarojini Sengupta Maria Soler Artigas Hans-Christoph Steinhausen Anita Thapar Stephanie H. Witt Li Yang Tetyana Zayats Yanli Zhang-James Bru Cormand David M. Hougaard Benjamin M. Neale Barbara Franke Stephen V. Faraone Anders D. Børglum Springer US Nature Communications, doi:10.1038/s41467-020-20443-2 10.1038/s41467-020-20443-2 http://dx.doi.org/10.1038/s41467-020-20443-2 journal Nature Communications © 2021, The Author(s) 2041-1723 10.1038/s41467-020-20443-2 springer.com springerlink.com 2010-04-23 True 10.1038/s41467-020-20443-2 springer.com springerlink.com Springer 2021-01-19T16:53:54+01:00 2021-01-18T22:35:16+05:30 2021-01-19T16:53:54+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:51facb45-207f-4332-a517-a36e8356afe2 uuid:55a651d4-5392-4313-84ff-e9ac4e20ee62 default 1 converted uuid:3e54ca13-072b-400d-bf33-d43528f291e3 converted to PDF/A-2b pdfToolbox 2021-01-18T22:36:08+05:30 2 B Ditte Demontis http://orcid.org/0000-0001-9124-2766 Raymond K. Walters http://orcid.org/0000-0001-8422-6530 Veera M. Rajagopal http://orcid.org/0000-0002-5236-168X Irwin D. Waldman http://orcid.org/0000-0002-6862-1837 Jakob Grove http://orcid.org/0000-0003-2284-5744 Thomas D. 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