a6b8a9e5bd73810d4a6047035508c9b3 pmc_33498379.pdf b6d69698ed1d106cc2af6d733428628627fe017b pmc_33498379.pdf 27543d964ed98d53d50686e063dac58c9e0371d9bde57e229fc003cdfc0414e0 pmc_33498379.pdf Title: Body Mass Index and Disease Activity in Chronic Inflammatory Rheumatic Diseases: Results of the Cardiovascular in Rheumatology (Carma) Project Subject: Objective: Since obesity has been associated with a higher inflammatory burden and worse response to therapy in patients with chronic inflammatory rheumatic diseases (CIRD), we aimed to confirm the potential association between body mass index (BMI) and disease activity in a large series of patients with CIRDs included in the Spanish CARdiovascular in rheuMAtology (CARMA) registry. Methods: Baseline data analysis of patients included from the CARMA project, a 10-year prospective study of patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) attending outpatient rheumatology clinics from 67 Spanish hospitals. Obesity was defined when BMI (kg/m2) was >30 according to the WHO criteria. Scores used to evaluate disease activity were Disease Activity Score of 28 joints (DAS28) in RA, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in AS, and modified DAS for PsA. Results: Data from 2234 patients (775 RA, 738 AS, and 721 PsA) were assessed. The mean SD BMI at the baseline visit were: 26.9 4.8 in RA, 27.4 4.4 in AS, and 28.2 4.7 in PsA. A positive association between BMI and disease activity in patients with RA ( = 0.029; 95%CI (0.01–0.05); p = 0.007) and PsA ( = 0.036; 95%CI (0.015–0.058); p = 0.001) but not in those with AS ( = 0.001; 95%CI (-0.03–0.03); p = 0.926) was found. Disease activity was associated with female sex and rheumatoid factor in RA and with Psoriasis Area Severity Index and enthesitis in PsA. Conclusions: BMI is associated with disease activity in RA and PsA, but not in AS. Given that obesity is a potentially modifiable factor, adequate control of body weight can improve the outcome of patients with CIRD and, therefore, weight control should be included in the management strategy of these patients. Keywords: body mass index; obesity; rheumatoid arthritis; ankylosing spondylitis; psoriatic arthritis and disease activity Author: Jesús A. Valero-Jaimes, Ruth López-González, María A. Martín-Martínez, Carmen García-Gómez, Fernando Sánchez-Alonso, Jesús T. Sánchez-Costa, Carlos González-Juanatey, Eva Revuelta-Evrad, César Díaz-Torné, Cruz Fernández-Espartero, Carolina Pérez-García, Vicenç Torrente-Segarra, Ginés Sánchez-Nievas, Trinidad Pérez-Sandoval, Pilar Font-Ugalde, María L. García-Vivar, Elena Aurrecoechea, Olga Maiz-Alonso, Ramón Valls-García, José A. Miranda-Filloy, Javier Llorca, Santos Castañeda and Miguel A. Gonzalez-Gay Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Jan 25 14:30:42 2021 CET ModDate: Mon Jan 25 14:36:45 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 302606 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EXDDUX+VnURWPalladioL Type 1 Custom yes yes no 10 0 AUOFGE+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 SCMGOE+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 PDTLRO+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 DGBDNV+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 81 0 GQWIGS+CMSY10 Type 1 Builtin yes yes no 85 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 95 0 ZYYJXI+EURB10 Type 1 Builtin yes yes no 105 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 118 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:33:48 CEST RepresentationInformation: pmc_33498379.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:08:40 CEST Size: 302606 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 248 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Patients and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Patient Recruitment Destination: subsection.2.2 Item: Title: Variables and Operative Definitions Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: General Characteristics of the Patients Destination: subsection.3.1 Item: Title: Association between Body Mass Index and Disease Activity Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: section.4 Info: Title: Body Mass Index and Disease Activity in Chronic Inflammatory Rheumatic Diseases: Results of the Cardiovascular in Rheumatology (Carma) Project Author: Jesús A. Valero-Jaimes, Ruth López-González, María A. Martín-Martínez, Carmen García-Gómez, Fernando Sánchez-Alonso, Jesús T. Sánchez-Costa, Carlos González-Juanatey, Eva Revuelta-Evrad, César Díaz-Torné, Cruz Fernández-Espartero, Carolina Pérez-García, Vicenç Torrente-Segarra, Ginés Sánchez-Nievas, Trinidad Pérez-Sandoval, Pilar Font-Ugalde, María L. García-Vivar, Elena Aurrecoechea, Olga Maiz-Alonso, Ramón Valls-García, José A. Miranda-Filloy, Javier Llorca, Santos Castañeda and Miguel A. Gonzalez-Gay Subject: Objective: Since obesity has been associated with a higher inflammatory burden and worse response to therapy in patients with chronic inflammatory rheumatic diseases (CIRD), we aimed to confirm the potential association between body mass index (BMI) and disease activity in a large series of patients with CIRDs included in the Spanish CARdiovascular in rheuMAtology (CARMA) registry. Methods: Baseline data analysis of patients included from the CARMA project, a 10-year prospective study of patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) attending outpatient rheumatology clinics from 67 Spanish hospitals. Obesity was defined when BMI (kg/m2) was >30 according to the WHO criteria. Scores used to evaluate disease activity were Disease Activity Score of 28 joints (DAS28) in RA, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in AS, and modified DAS for PsA. Results: Data from 2234 patients (775 RA, 738 AS, and 721 PsA) were assessed. The mean SD BMI at the baseline visit were: 26.9 4.8 in RA, 27.4 4.4 in AS, and 28.2 4.7 in PsA. A positive association between BMI and disease activity in patients with RA ( = 0.029; 95%CI (0.01 0.05); p = 0.007) and PsA ( = 0.036; 95%CI (0.015 0.058); p = 0.001) but not in those with AS ( = 0.001; 95%CI (-0.03 0.03); p = 0.926) was found. Disease activity was associated with female sex and rheumatoid factor in RA and with Psoriasis Area Severity Index and enthesitis in PsA. Conclusions: BMI is associated with disease activity in RA and PsA, but not in AS. Given that obesity is a potentially modifiable factor, adequate control of body weight can improve the outcome of patients with CIRD and, therefore, weight control should be included in the management strategy of these patients. 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