6869b30f109fbd3d5eb187a78b95bbb4 pmc_33510223.pdf 1b759af4d14184b63939ae5f0217fe2dc8602cda pmc_33510223.pdf 5216ef9075c83d3e6985b5239d76b193957659fba5bd9f7c56d68664b904da0d pmc_33510223.pdf Title: Assessment of the biological potential of diaryltriazene-derived triazene compounds Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-81823-2 Author: Patricia de Maria Silva Figueirêdo Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Jan 22 16:06:13 2021 CET ModDate: Sat Jan 23 06:53:31 2021 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2205733 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AUVJXU+Wingdings-Regular Type 1C WinAnsi yes yes yes 419 0 MinionPro-It Type 1C Custom yes no yes 83 0 MinionPro-Regular Type 1C Custom yes no yes 81 0 Corbel-BoldItalic TrueType WinAnsi yes no yes 138 0 ZGNDVZ+Corbel-Bold CID TrueType Identity-H yes yes yes 85 0 Corbel-Bold2 TrueType WinAnsi yes no yes 420 0 Corbel2 TrueType WinAnsi yes no yes 86 0 TCPTPL+Corbel CID TrueType Identity-H yes yes yes 87 0 Corbel2 TrueType WinAnsi yes no yes 365 0 MinionPro-Bold Type 1C Custom yes no yes 82 0 UYWAYJ+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 84 0 NLKKEX+MinionPro-It2 Type 1C Custom yes yes no 137 0 MHVEQZ+MTMI Type 1C Custom yes yes no 139 0 MHVEQZ+MTSYN Type 1C Custom yes yes no 140 0 MHVEQZ+MinionPro-Regular2 Type 1C Custom yes yes no 141 0 MHVEQZ+TimesNewRomanPS-BoldMT Type 1C WinAnsi yes yes no 167 0 LILYCB+TimesNewRomanPSMT2 Type 1C WinAnsi yes yes no 168 0 LILYCB+Code2000 CID TrueType Identity-H yes yes yes 204 0 MinionPro-BoldIt Type 1C WinAnsi yes no yes 237 0 TimesNewRomanPSMT3 TrueType WinAnsi yes no yes 312 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:33:30 CEST RepresentationInformation: pmc_33510223.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:08:42 CEST Size: 2205733 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 515 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Assessment of the biological potential of diaryltriazene-derived triazene compounds Children: Item: Title: Experimental Children: Item: Title: Materials, instrumentation, and methods. Item: Title: Tested microorganisms. Item: Title: Agar diffusion antimicrobial activity test. Item: Title: Determination of minimum inhibitory concentration (MIC). Item: Title: Antifungal activity against filamentous fungi using the poisoned food method. Item: Title: Determination of antibiotic potency. Item: Title: Assessment of mucous membrane irritation potential. Item: Title: MTT cytotoxicity test. Item: Title: Ecotoxicity test using Danio rerio (zebrafish). Item: Title: Animal assay. Item: Title: Statistical analyses. Item: Title: Results and discussion Children: Item: Title: Chemistry. Item: Title: X-ray crystallography. Item: Title: Biological activity. Children: Item: Title: Agar diffusion antimicrobial activity test. Item: Title: Determination of the MIC and CBMCFM of the selected species. Item: Title: Antifungal activity against filamentous fungi determined by the poisoned food method. Item: Title: Determination of the antibiotic effect. Item: Title: Assessment of mucous membrane irritation potential. Item: Title: Cytotoxic assay by MTT. Item: Title: Ecotoxicity test with Danio rerio. Item: Title: Conclusion Item: Title: References Item: Title: Acknowledgements Info: Title: Assessment of the biological potential of diaryltriazene-derived triazene compounds Author: Patricia de Maria Silva Figueirêdo Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-81823-2 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Jan 22 16:36:13 CET 2021 ModDate: Sat Jan 23 06:53:31 CET 2021 ID: 0x235d51c2a03b4c2b9c2c2d1f08500938, 0x8bb46ea3c080a2f8a2027e1657b62c71 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 969 ImageHeight: 678 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1985 ImageHeight: 1320 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1340 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1488 ImageHeight: 643 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 827 ImageHeight: 650 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1985 ImageHeight: 1368 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: UYWAYJ+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: ZGNDVZ+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: TCPTPL+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: LILYCB+Code2000 Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AUVJXU+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AUVJXU+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MHVEQZ+TimesNewRomanPS-BoldMT FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: MHVEQZ+TimesNewRomanPS-BoldMT Flags: Nonsymbolic FontBBox: -558, -307, 2000, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILYCB+TimesNewRomanPSMT2 FontSubset: true FirstChar: 32 LastChar: 79 FontDescriptor: FontName: LILYCB+TimesNewRomanPSMT2 Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NLKKEX+MinionPro-It2 FontSubset: true FirstChar: 26 LastChar: 32 FontDescriptor: FontName: NLKKEX+MinionPro-It2 Flags: Symbolic, SmallCap FontBBox: -4, -15, 903, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MHVEQZ+MTMI FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: MHVEQZ+MTMI Flags: Symbolic, AllCap FontBBox: 0, -207, 369, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MHVEQZ+MTSYN FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: MHVEQZ+MTSYN Flags: Symbolic FontBBox: 0, 0, 724, 461 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MHVEQZ+MinionPro-Regular2 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: MHVEQZ+MinionPro-Regular2 Flags: Symbolic, AllCap FontBBox: 0, -12, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MinionPro-BoldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-BoldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -230, -360, 1684, 1032 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: Corbel-Bold2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TimesNewRomanPSMT3 FirstChar: 32 LastChar: 121 FontDescriptor: FontName: TimesNewRomanPSMT3 Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: LILYCB+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LILYCB+Code2000 Flags: Serif, Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true Font: BaseFont: ZGNDVZ+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ZGNDVZ+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: UYWAYJ+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UYWAYJ+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: TCPTPL+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TCPTPL+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true XMP: 2021-01-22T20:36:13+05:30 Springer 2021-01-23T06:53:31+01:00 2021-01-23T06:53:31+01:00 application/pdf https://doi.org/10.1038/s41598-021-81823-2 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-021-81823-2 Assessment of the biological potential of diaryltriazene-derived triazene compounds Patricia de Maria Silva Figueirêdo José Costa Sampaio Filho Alzirene de Jesus Sales Sodré José Ribamar de Castro Júnior Ingrid Santos Gonçalves Rodrigo Vieira Blasques Rodrigo S. Correa Benedicto Augusto Vieira Lima Larissa dos Anjos Marques Denise Fernandes Coutinho Ana Paula Silva de Azevedo dos Santos Tássio Rômulo Silva Araújo Luz Rita de Cassia Mendonça de Miranda Julliana Ribeiro Alves dos Santos Antonio Carlos Doriguetto María Isabel Pividori Manfredo Hörner Paulo Cesar Mendes Villis 10.1038/s41598-021-81823-2 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-021-81823-2 10.1038/s41598-021-81823-2 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-021-81823-2 noindex springer.com springerlink.com VoR uuid:35e36730-5150-46f5-a867-06fa6a71f3e2 uuid:031ebfc0-30b9-4e78-87fe-3cc507b6daa6 default 1 converted uuid:34b15b15-6da7-4b97-8333-5a156fd31fd1 converted to PDF/A-2b pdfToolbox 2021-01-22T20:36:54+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 533, 281, 536, 269 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 328, 271, 331, 259 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 338, 261, 341, 249 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 274, 241, 277, 229 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 327, 241, 330, 229 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 526, 241, 529, 229 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 532, 241, 535, 229 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 306, 231, 309, 219 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 498, 231, 503, 219 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 204, 211, 209, 199 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 356, 201, 362, 189 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 363, 201, 369, 189 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 481, 675, 556, 658 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 328, 486, 333, 474 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 335, 486, 340, 474 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 430, 486, 436, 474 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 439, 486, 445, 474 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 364, 476, 370, 464 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 371, 476, 377, 464 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 499, 476, 504, 464 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 506, 476, 511, 464 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 178, 466, 184, 454 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 187, 466, 193, 454 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 290, 466, 296, 454 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 392, 466, 397, 454 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 546, 466, 552, 454 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 220, 456, 226, 444 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 433, 456, 439, 444 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 296, 446, 299, 434 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 300, 446, 306, 434 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 309, 446, 315, 434 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 226, 426, 232, 414 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 274, 426, 280, 414 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 312, 406, 317, 394 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 443, 406, 448, 394 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 279, 386, 284, 374 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 212, 376, 218, 364 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 443, 336, 449, 324 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 450, 336, 456, 324 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 213, 326, 218, 314 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 429, 276, 435, 264 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 492, 266, 494, 254 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 475, 256, 480, 244 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 361, 236, 366, 224 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 189, 206, 195, 194 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 408, 206, 414, 194 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 397, 196, 403, 184 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 461, 186, 467, 174 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 206, 176, 212, 164 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 213, 176, 219, 164 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 285, 176, 291, 164 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 374, 176, 379, 164 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 449, 176, 455, 164 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 326, 156, 331, 144 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 245, 146, 250, 134 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 252, 146, 257, 134 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 215, 136, 221, 124 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 454, 136, 460, 124 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 437, 126, 443, 114 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 498, 96, 503, 84 Flags: Print AppearanceDictionary: true Destination: 319 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 404, 453, 409, 440 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 169, 288, 175, 276 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 461, 278, 467, 266 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 546, 246, 552, 234 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 498, 186, 504, 174 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 388, 176, 394, 164 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 336, 144, 341, 132 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 500, 104, 506, 92 Flags: Print AppearanceDictionary: true Destination: 319 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 539, 714, 545, 702 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 345, 694, 350, 682 Flags: Print AppearanceDictionary: true Destination: 114 Annotation: Subtype: Link Rect: 330, 499, 335, 487 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 295, 479, 301, 467 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 391, 397, 397, 385 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 303, 327, 370, 315 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 159, 307, 242, 295 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 207, 265, 212, 253 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 286, 193, 438, 181 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 193, 447, 181 Flags: Print AppearanceDictionary: true Destination: 319 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 510, 112, 516, 100 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 195, 102, 199, 90 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 324, 102, 328, 90 Flags: Print AppearanceDictionary: true Destination: 158 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 324, 476, 329, 463 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 462, 455, 468, 443 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 457, 445, 462, 433 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 293, 426, 298, 413 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 449, 416, 455, 403 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 343, 405, 349, 393 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 222, 385, 227, 373 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 279, 355, 285, 343 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 286, 355, 292, 343 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 266, 336, 271, 323 Flags: Print AppearanceDictionary: true Destination: 179 Annotation: Subtype: Link Rect: 207, 316, 213, 303 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 217, 306, 223, 293 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 456, 306, 461, 293 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 404, 265, 409, 253 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 426, 265, 431, 253 Flags: Print AppearanceDictionary: true Destination: 179 Annotation: Subtype: Link Rect: 229, 93, 233, 81 Flags: Print AppearanceDictionary: true Destination: 213 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 325, 98, 329, 86 Flags: Print AppearanceDictionary: true Destination: 213 Annotation: Subtype: Link Rect: 244, 88, 249, 76 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 325, 88, 331, 76 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 202, 68, 208, 56 Flags: Print AppearanceDictionary: true Destination: 319 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 544, 181, 548, 169 Flags: Print AppearanceDictionary: true Destination: 223 Annotation: Subtype: Link Rect: 546, 161, 552, 149 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 261, 151, 267, 139 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 183, 131, 189, 119 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 494, 79, 498, 67 Flags: Print AppearanceDictionary: true Destination: 223 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 193, 234, 197, 221 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 488, 214, 492, 201 Flags: Print AppearanceDictionary: true Destination: 223 Annotation: Subtype: Link Rect: 517, 214, 521, 201 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 460, 194, 465, 181 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 383, 82, 387, 69 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 219, 72, 223, 59 Flags: Print AppearanceDictionary: true Destination: 260 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 406, 241, 411, 229 Flags: Print AppearanceDictionary: true Destination: 260 Annotation: Subtype: Link Rect: 466, 191, 471, 179 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 377, 161, 383, 149 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 207, 129, 212, 117 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 338, 89, 341, 77 Flags: Print AppearanceDictionary: true Destination: 308 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 371, 261, 376, 248 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 202, 200, 206, 188 Flags: Print AppearanceDictionary: true Destination: 297 Annotation: Subtype: Link Rect: 294, 200, 300, 188 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 249, 190, 255, 178 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 256, 190, 262, 178 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 394, 161, 397, 148 Flags: Print AppearanceDictionary: true Destination: 308 Annotation: Subtype: Link Rect: 193, 120, 197, 108 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 191, 90, 197, 78 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 499, 80, 505, 68 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 506, 80, 512, 68 Flags: Print AppearanceDictionary: true Destination: 339 Annotation: Subtype: Link Rect: 513, 80, 519, 68 Flags: Print AppearanceDictionary: true Destination: 339 Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 511, 173, 515, 161 Flags: Print AppearanceDictionary: true Destination: 297 Annotation: Subtype: Link Rect: 273, 153, 278, 141 Flags: Print AppearanceDictionary: true Destination: 319 Annotation: Subtype: Link Rect: 224, 103, 230, 91 Flags: Print AppearanceDictionary: true Destination: 319 Thumb: true Page: Sequence: 13 Thumb: true Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 368, 283, 521, 273 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 468, 181, 554, 171 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 172, 262, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 539, 147, 554, 137 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 138, 554, 128 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 130, 245, 120 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 514, 270, 554, 257 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 259, 275, 247 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 230, 443, 217 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 358, 119, 517, 107 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 60c2e0bc Type: CRC32 Checksum: 6869b30f109fbd3d5eb187a78b95bbb4 Type: MD5 Checksum: 1b759af4d14184b63939ae5f0217fe2dc8602cda Type: SHA-1 Checksum: 5216ef9075c83d3e6985b5239d76b193957659fba5bd9f7c56d68664b904da0d Type: SHA-256