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Title:           A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
Subject:         Genome Medicine, 2021, doi:10.1186/s13073-020-00816-4
Keywords:        Pancreatic cancer risk,Genome-wide association analysis,Genetic susceptibility,3D genomic structure,Local indices of genome spatial autocorrelation
Author:          Evangelina López de Maturana
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     Item: 
      Title: Abstract
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       Item: 
        Title: Background
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       Item: 
        Title: Methods
        Destination: sectionASec2
       Item: 
        Title: Results
        Destination: sectionASec3
       Item: 
        Title: Conclusions
        Destination: sectionASec4
     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: 1D approach: PanGenEU GWAS—single marker association analyses
        Destination: sectionSec3
        Children: 
         Item: 
          Title: Study population
          Destination: sectionSec4
         Item: 
          Title: Genotyping and quality control of PanGenEU study subjects
          Destination: sectionSec5
         Item: 
          Title: Genotyping and quality control of SBC/EPICURO controls
          Destination: sectionSec6
         Item: 
          Title: Imputation
          Destination: sectionSec7
         Item: 
          Title: Association analyses
          Destination: sectionSec8
         Item: 
          Title: Validation of the novel GWAS hits
          Destination: sectionSec9
       Item: 
        Title: 2D approach: Local Moran Index
        Destination: sectionSec10
        Children: 
         Item: 
          Title: Local Moran’s Index calculation
          Destination: sectionSec11
       Item: 
        Title: 3D approach: Hi-C pancreas interaction maps and interaction selection
        Destination: sectionSec12
       Item: 
        Title: Functional in silico analysis
        Destination: sectionSec13
     Item: 
      Title: Results
      Destination: sectionSec14
      Children: 
       Item: 
        Title: 1D approach: PanGenEU GWAS—single marker association analyses
        Destination: sectionSec15
        Children: 
         Item: 
          Title: Replication of previously reported GWAS hits
          Destination: sectionSec16
         Item: 
          Title: The top 20 PanGenEU GWAS hits: validation in independent populations
          Destination: sectionSec17
       Item: 
        Title: 2D approach: genomic spatial integration
        Destination: sectionSec18
       Item: 
        Title: 3D approach: genomic interaction analysis
        Destination: sectionSec19
       Item: 
        Title: Functional in silico validation
        Destination: sectionSec20
        Children: 
         Item: 
          Title: Assessment of potential functionality of the variants
          Destination: sectionSec21
         Item: 
          Title: Gene set enrichment analyses (GSEA)
          Destination: sectionSec22
         Item: 
          Title: Pathway enrichment analysis
          Destination: sectionSec23
     Item: 
      Title: Discussion
      Destination: sectionSec24
     Item: 
      Title: Conclusions
      Destination: sectionSec25
     Item: 
      Title: Supplementary Information
      Destination: sectionSec26
     Item: 
      Title: Abbreviations
      Destination: sectionabr1
     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
      Destination: section4
     Item: 
      Title: Ethics approval and consent to participate
      Destination: sectionFPar1
     Item: 
      Title: Consent for publication
      Destination: sectionFPar2
     Item: 
      Title: Competing interests
      Destination: sectionFPar3
     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
      Destination: sectionBib1
     Item: 
      Title: Publisher’s Note
      Destination: ArtNote1
   Info: 
    Title: A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
    Author: Evangelina López de Maturana
    Subject: Genome Medicine, 2021, doi:10.1186/s13073-020-00816-4
    Keywords: Pancreatic cancer risk,Genome-wide association analysis,Genetic susceptibility,3D genomic structure,Local indices of genome spatial autocorrelation
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