36e2f02ba61febc7e41fd0f96dfd28a0 pmc_33551753.pdf dbaab6413242244891c0c2c059929c18fd84b4a1 pmc_33551753.pdf 554b88e7ebeb31b23d349b5cc107ca381a69c97c295dacb12f43c037bcc8d2d4 pmc_33551753.pdf Title: Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy Subject: Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare genetic disorder belonging to the group of vacuolating leukodystrophies. Keywords: myelin abnormalities, ion channel, water homeostasis, chloride, cell-cell adhesion Author: Assumpció Bosch and Raúl Estévez Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Mon Jan 18 10:13:09 2021 CET ModDate: Mon Jan 18 13:44:33 2021 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3702157 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XTKTOP+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 854 0 QZIALI+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 855 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 856 0 TAWZTV+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 857 0 HBAIYM+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 858 0 HSZNFB+MinionPro-It Type 1 Custom yes yes no 666 0 FXEJFY+MinionPro-Regular Type 1 Custom yes yes no 673 0 FGZFEN+MinionPro-Bold Type 1 Custom yes yes no 667 0 QHWLRN+MTGU Type 1 Builtin yes yes no 679 0 GDNWHS+MTSYN Type 1 Builtin yes yes no 681 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:32:23 CEST RepresentationInformation: pmc_33551753.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:08:47 CEST Size: 3702157 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 958 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy Children: Item: Title: INTRODUCTION Item: Title: EFFECT OF MLC MUTATIONS INTO GLIALCAM AND MLC1 CELL BIOLOGY Item: Title: INSIGHTS INTO GLIALCAM/MLC1 FUNCTION AND PATHOPHYSIOLOGY OF MLC Item: Title: ANIMAL MODELS OF MLC: ZEBRAFISH AND MICE Item: Title: GENE THERAPY FOR MLC Item: Title: CONCLUSIONS AND PERSPECTIVES Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: REFERENCES Info: Title: Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy Author: Assumpció Bosch and Raúl Estévez Subject: Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare genetic disorder belonging to the group of vacuolating leukodystrophies. Keywords: myelin abnormalities, ion channel, water homeostasis, chloride, cell-cell adhesion Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Mon Jan 18 10:43:09 CET 2021 ModDate: Mon Jan 18 14:14:33 CET 2021 ID: 0x84611dd7fef93368cb04b05dc718912f, 0x22b408a23ebcf3458784ae11be7cd9a9 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: FXEJFY+MinionPro-Regular FontSubset: true FirstChar: 37 LastChar: 246 FontDescriptor: FontName: FXEJFY+MinionPro-Regular Flags: Symbolic FontBBox: -288, -358, 1684, 989 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XTKTOP+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: XTKTOP+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -164, -216, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QZIALI+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: QZIALI+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -164, -212, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QHWLRN+MTGU FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: QHWLRN+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -164, -216, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TAWZTV+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: TAWZTV+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -163, -212, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GDNWHS+MTSYN FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: GDNWHS+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: HBAIYM+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 250 FontDescriptor: FontName: HBAIYM+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -163, -216, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HSZNFB+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 233 FontDescriptor: FontName: HSZNFB+MinionPro-It Flags: Symbolic FontBBox: -199, -358, 1684, 1002 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FGZFEN+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: FGZFEN+MinionPro-Bold Flags: Symbolic FontBBox: -317, -358, 1684, 1024 FontFile: true EncodingDictionary: Differences: true XMP: 2021-01-18T14:43:09+05:30 LaTeX with hyperref package 2021-01-18T18:14:33+05:30 2021-01-18T18:14:33+05:30 application/pdf Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare genetic disorder belonging to the group of vacuolating leukodystrophies. Assumpció Bosch and Raúl Estévez Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy myelin abnormalities ion channel water homeostasis chloride cell-cell adhesion myelin abnormalities, ion channel, water homeostasis, chloride, cell-cell adhesion pdfTeX-1.40.12 False This is MiKTeX-pdfTeX 2.9.4487 (1.40.12) uuid:48ab180f-0382-4abb-a7b2-058a2161d519 uuid:8fb3b385-40ea-4cba-9f7b-66289a2d6dee Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 44, 720, 211, 753 Annotation: Subtype: Link Rect: 521, 733, 550, 746 Annotation: Subtype: Link Rect: 464, 725, 550, 738 Annotation: Subtype: Link Rect: 451, 717, 550, 731 Annotation: Subtype: Link Rect: 521, 676, 550, 707 Annotation: Subtype: Link Rect: 87, 428, 158, 437 Annotation: Subtype: Link Rect: 75, 268, 158, 276 Annotation: Subtype: Link Rect: 105, 249, 158, 257 Annotation: Subtype: Link Rect: 59, 65, 158, 73 Annotation: Subtype: Link Rect: 173, 535, 550, 628 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 552, 39 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 118, 614, 203, 625 ActionDest: 607 Annotation: Subtype: Link Rect: 207, 614, 227, 625 ActionDest: 607 Annotation: Subtype: Link Rect: 155, 579, 220, 590 ActionDest: 557 Annotation: Subtype: Link Rect: 225, 579, 245, 590 ActionDest: 557 Annotation: Subtype: Link Rect: 174, 522, 252, 533 ActionDest: 607 Annotation: Subtype: Link Rect: 254, 522, 274, 533 ActionDest: 607 Annotation: Subtype: Link Rect: 111, 465, 202, 476 ActionDest: 654 Annotation: Subtype: Link Rect: 208, 465, 228, 476 ActionDest: 654 Annotation: Subtype: Link Rect: 47, 397, 106, 407 ActionDest: 557 Annotation: Subtype: Link Rect: 108, 397, 129, 407 ActionDest: 557 Annotation: Subtype: Link Rect: 133, 362, 194, 373 ActionDest: 607 Annotation: Subtype: Link Rect: 197, 362, 217, 373 ActionDest: 607 Annotation: Subtype: Link Rect: 220, 362, 291, 373 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 350, 65, 361 ActionDest: 607 Annotation: Subtype: Link Rect: 68, 350, 92, 361 ActionDest: 607 Annotation: Subtype: Link Rect: 97, 304, 193, 315 ActionDest: 607 Annotation: Subtype: Link Rect: 198, 304, 223, 315 ActionDest: 607 Annotation: Subtype: Link Rect: 47, 224, 124, 235 ActionDest: 607 Annotation: Subtype: Link Rect: 127, 224, 147, 235 ActionDest: 607 Annotation: Subtype: Link Rect: 262, 190, 291, 201 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 179, 66, 189 ActionDest: 607 Annotation: Subtype: Link Rect: 70, 179, 90, 189 ActionDest: 607 Annotation: Subtype: Link Rect: 95, 179, 115, 189 ActionDest: 607 Annotation: Subtype: Link Rect: 119, 179, 164, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 169, 179, 189, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 193, 179, 261, 189 ActionDest: 532 Annotation: Subtype: Link Rect: 265, 179, 285, 189 ActionDest: 532 Annotation: Subtype: Link Rect: 90, 132, 143, 144 ActionDest: 557 Annotation: Subtype: Link Rect: 147, 132, 168, 144 ActionDest: 557 Annotation: Subtype: Link Rect: 172, 132, 233, 144 ActionDest: 607 Annotation: Subtype: Link Rect: 238, 132, 258, 144 ActionDest: 607 Annotation: Subtype: Link Rect: 263, 132, 291, 144 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 121, 65, 132 ActionDest: 607 Annotation: Subtype: Link Rect: 69, 121, 89, 132 ActionDest: 607 Annotation: Subtype: Link Rect: 105, 109, 147, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 151, 109, 171, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 195, 87, 289, 98 ActionDest: 532 Annotation: Subtype: Link Rect: 44, 75, 64, 86 ActionDest: 532 Annotation: Subtype: Link Rect: 474, 706, 548, 716 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 695, 323, 705 ActionDest: 557 Annotation: Subtype: Link Rect: 522, 671, 550, 682 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 661, 371, 671 ActionDest: 607 Annotation: Subtype: Link Rect: 376, 661, 400, 671 ActionDest: 607 Annotation: Subtype: Link Rect: 405, 661, 460, 671 ActionDest: 532 Annotation: Subtype: Link Rect: 464, 661, 488, 671 ActionDest: 532 Annotation: Subtype: Link Rect: 488, 661, 495, 671 ActionDest: 532 Annotation: Subtype: Link Rect: 500, 661, 550, 671 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 648, 325, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 329, 648, 349, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 404, 614, 455, 625 ActionDest: 532 Annotation: Subtype: Link Rect: 458, 614, 482, 625 ActionDest: 532 Annotation: Subtype: Link Rect: 383, 580, 453, 590 ActionDest: 557 Annotation: Subtype: Link Rect: 456, 580, 476, 590 ActionDest: 557 Annotation: Subtype: Link Rect: 409, 557, 502, 568 ActionDest: 557 Annotation: Subtype: Link Rect: 506, 557, 526, 568 ActionDest: 557 Annotation: Subtype: Link Rect: 345, 533, 437, 545 ActionDest: 607 Annotation: Subtype: Link Rect: 440, 533, 465, 545 ActionDest: 607 Annotation: Subtype: Link Rect: 392, 476, 481, 487 ActionDest: 557 Annotation: Subtype: Link Rect: 484, 476, 504, 487 ActionDest: 557 Annotation: Subtype: Link Rect: 375, 396, 429, 407 ActionDest: 607 Annotation: Subtype: Link Rect: 434, 396, 454, 407 ActionDest: 607 Annotation: Subtype: Link Rect: 353, 385, 408, 396 ActionDest: 607 Annotation: Subtype: Link Rect: 414, 385, 435, 396 ActionDest: 607 Annotation: Subtype: Link Rect: 387, 373, 483, 384 ActionDest: 607 Annotation: Subtype: Link Rect: 489, 373, 514, 384 ActionDest: 607 Annotation: Subtype: Link Rect: 306, 362, 356, 373 ActionDest: 557 Annotation: Subtype: Link Rect: 358, 362, 379, 373 ActionDest: 557 Annotation: Subtype: Link Rect: 507, 362, 550, 373 ActionDest: 532 Annotation: Subtype: Link Rect: 303, 350, 325, 361 ActionDest: 532 Annotation: Subtype: Link Rect: 330, 350, 350, 361 ActionDest: 532 Annotation: Subtype: Link Rect: 487, 350, 548, 361 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 339, 323, 350 ActionDest: 607 Annotation: Subtype: Link Rect: 469, 328, 522, 338 ActionDest: 557 Annotation: Subtype: Link Rect: 528, 328, 548, 338 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 316, 358, 327 ActionDest: 607 Annotation: Subtype: Link Rect: 363, 316, 384, 327 ActionDest: 607 Annotation: Subtype: Link Rect: 389, 316, 453, 327 ActionDest: 557 Annotation: Subtype: Link Rect: 459, 316, 479, 327 ActionDest: 557 Annotation: Subtype: Link Rect: 415, 282, 467, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 471, 282, 491, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 496, 282, 548, 293 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 270, 323, 281 ActionDest: 607 Annotation: Subtype: Link Rect: 306, 168, 359, 178 ActionDest: 557 Annotation: Subtype: Link Rect: 363, 168, 383, 178 ActionDest: 557 Annotation: Subtype: Link Rect: 471, 168, 523, 178 ActionDest: 557 Annotation: Subtype: Link Rect: 528, 168, 548, 178 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 155, 362, 167 ActionDest: 557 Annotation: Subtype: Link Rect: 365, 155, 385, 167 ActionDest: 557 Annotation: Subtype: Link Rect: 499, 155, 548, 167 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 144, 323, 155 ActionDest: 557 Annotation: Subtype: Link Rect: 439, 144, 492, 155 ActionDest: 557 Annotation: Subtype: Link Rect: 497, 144, 517, 155 ActionDest: 557 Annotation: Subtype: Link Rect: 522, 144, 550, 155 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 132, 325, 144 ActionDest: 607 Annotation: Subtype: Link Rect: 329, 132, 349, 144 ActionDest: 607 Annotation: Subtype: Link Rect: 306, 121, 398, 132 ActionDest: 607 Annotation: Subtype: Link Rect: 401, 121, 426, 132 ActionDest: 607 Annotation: Subtype: Link Rect: 430, 121, 471, 132 ActionDest: 105 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 143, 318, 215, 326 ActionDest: 607 Annotation: Subtype: Link Rect: 216, 318, 238, 326 ActionDest: 607 Annotation: Subtype: Link Rect: 162, 280, 216, 289 ActionDest: 557 Annotation: Subtype: Link Rect: 217, 280, 235, 289 ActionDest: 557 Annotation: Subtype: Link Rect: 89, 201, 132, 212 ActionDest: 105 Annotation: Subtype: Link Rect: 214, 156, 289, 167 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 145, 64, 155 ActionDest: 557 Annotation: Subtype: Link Rect: 238, 109, 291, 121 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 98, 67, 109 ActionDest: 557 Annotation: Subtype: Link Rect: 72, 98, 92, 109 ActionDest: 557 Annotation: Subtype: Link Rect: 306, 672, 365, 682 ActionDest: 557 Annotation: Subtype: Link Rect: 368, 672, 388, 682 ActionDest: 557 Annotation: Subtype: Link Rect: 352, 626, 410, 636 ActionDest: 532 Annotation: Subtype: Link Rect: 416, 626, 441, 636 ActionDest: 532 Annotation: Subtype: Link Rect: 461, 510, 522, 522 ActionDest: 607 Annotation: Subtype: Link Rect: 524, 510, 545, 522 ActionDest: 607 Annotation: Subtype: Link Rect: 371, 477, 421, 487 ActionDest: 557 Annotation: Subtype: Link Rect: 423, 477, 444, 487 ActionDest: 557 Annotation: Subtype: Link Rect: 415, 453, 481, 464 ActionDest: 607 Annotation: Subtype: Link Rect: 487, 453, 507, 464 ActionDest: 607 Annotation: Subtype: Link Rect: 420, 407, 470, 419 ActionDest: 607 Annotation: Subtype: Link Rect: 472, 407, 493, 419 ActionDest: 607 Annotation: Subtype: Link Rect: 343, 373, 420, 384 ActionDest: 607 Annotation: Subtype: Link Rect: 422, 373, 442, 384 ActionDest: 607 Annotation: Subtype: Link Rect: 343, 316, 409, 327 ActionDest: 557 Annotation: Subtype: Link Rect: 415, 316, 436, 327 ActionDest: 557 Annotation: Subtype: Link Rect: 479, 293, 550, 304 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 281, 327, 293 ActionDest: 607 Annotation: Subtype: Link Rect: 333, 281, 357, 293 ActionDest: 607 Annotation: Subtype: Link Rect: 364, 281, 434, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 441, 281, 461, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 467, 281, 518, 293 ActionDest: 607 Annotation: Subtype: Link Rect: 524, 281, 545, 293 ActionDest: 607 Annotation: Subtype: Link Rect: 372, 258, 438, 270 ActionDest: 532 Annotation: Subtype: Link Rect: 441, 258, 461, 270 ActionDest: 532 Annotation: Subtype: Link Rect: 465, 258, 524, 270 ActionDest: 557 Annotation: Subtype: Link Rect: 528, 258, 548, 270 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 247, 323, 258 ActionDest: 557 Annotation: Subtype: Link Rect: 492, 235, 548, 247 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 224, 323, 235 ActionDest: 607 Annotation: Subtype: Link Rect: 373, 213, 403, 224 ActionDest: 160 Annotation: Subtype: Link Rect: 337, 132, 380, 144 ActionDest: 607 Annotation: Subtype: Link Rect: 382, 132, 402, 144 ActionDest: 607 Annotation: Subtype: Link Rect: 471, 98, 521, 109 ActionDest: 557 Annotation: Subtype: Link Rect: 524, 98, 545, 109 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 147, 660, 206, 668 ActionDest: 607 Annotation: Subtype: Link Rect: 109, 650, 125, 659 ActionDest: 607 Annotation: Subtype: Link Rect: 127, 650, 148, 659 ActionDest: 607 Annotation: Subtype: Link Rect: 111, 622, 183, 630 ActionDest: 607 Annotation: Subtype: Link Rect: 109, 613, 130, 621 ActionDest: 607 Annotation: Subtype: Link Rect: 131, 594, 203, 602 ActionDest: 607 Annotation: Subtype: Link Rect: 109, 584, 130, 593 ActionDest: 607 Annotation: Subtype: Link Rect: 111, 556, 183, 564 ActionDest: 607 Annotation: Subtype: Link Rect: 109, 545, 130, 555 ActionDest: 607 Annotation: Subtype: Link Rect: 238, 650, 308, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 210, 639, 227, 649 ActionDest: 557 Annotation: Subtype: Link Rect: 324, 650, 382, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 384, 650, 401, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 403, 650, 432, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 322, 641, 339, 649 ActionDest: 557 Annotation: Subtype: Link Rect: 341, 641, 358, 649 ActionDest: 557 Annotation: Subtype: Link Rect: 359, 622, 417, 630 ActionDest: 557 Annotation: Subtype: Link Rect: 322, 611, 340, 621 ActionDest: 557 Annotation: Subtype: Link Rect: 342, 611, 382, 621 ActionDest: 557 Annotation: Subtype: Link Rect: 384, 611, 402, 621 ActionDest: 557 Annotation: Subtype: Link Rect: 111, 503, 161, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 163, 503, 180, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 109, 493, 168, 502 ActionDest: 557 Annotation: Subtype: Link Rect: 170, 493, 187, 502 ActionDest: 557 Annotation: Subtype: Link Rect: 131, 474, 182, 483 ActionDest: 557 Annotation: Subtype: Link Rect: 184, 474, 201, 483 ActionDest: 557 Annotation: Subtype: Link Rect: 140, 455, 191, 464 ActionDest: 557 Annotation: Subtype: Link Rect: 109, 444, 126, 454 ActionDest: 557 Annotation: Subtype: Link Rect: 271, 512, 319, 521 ActionDest: 557 Annotation: Subtype: Link Rect: 210, 501, 226, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 228, 501, 246, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 247, 501, 265, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 356, 512, 414, 521 ActionDest: 557 Annotation: Subtype: Link Rect: 322, 503, 340, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 342, 503, 382, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 384, 503, 402, 511 ActionDest: 557 Annotation: Subtype: Link Rect: 379, 484, 432, 492 ActionDest: 557 Annotation: Subtype: Link Rect: 322, 473, 339, 483 ActionDest: 557 Annotation: Subtype: Link Rect: 341, 473, 358, 483 ActionDest: 557 Annotation: Subtype: Link Rect: 473, 512, 505, 521 ActionDest: 607 Annotation: Subtype: Link Rect: 507, 512, 524, 521 ActionDest: 607 Annotation: Subtype: Link Rect: 468, 484, 515, 492 ActionDest: 557 Annotation: Subtype: Link Rect: 517, 484, 535, 492 ActionDest: 557 Annotation: Subtype: Link Rect: 437, 454, 495, 464 ActionDest: 557 Annotation: Subtype: Link Rect: 497, 454, 514, 464 ActionDest: 557 Annotation: Subtype: Link Rect: 132, 402, 178, 411 ActionDest: 557 Annotation: Subtype: Link Rect: 179, 402, 197, 411 ActionDest: 557 Annotation: Subtype: Link Rect: 131, 383, 167, 392 ActionDest: 607 Annotation: Subtype: Link Rect: 169, 383, 186, 392 ActionDest: 607 Annotation: Subtype: Link Rect: 149, 365, 185, 373 ActionDest: 607 Annotation: Subtype: Link Rect: 109, 355, 126, 363 ActionDest: 607 Annotation: Subtype: Link Rect: 143, 336, 189, 345 ActionDest: 557 Annotation: Subtype: Link Rect: 109, 327, 126, 335 ActionDest: 557 Annotation: Subtype: Link Rect: 155, 308, 200, 316 ActionDest: 557 Annotation: Subtype: Link Rect: 109, 298, 126, 307 ActionDest: 557 Annotation: Subtype: Link Rect: 130, 259, 166, 269 ActionDest: 607 Annotation: Subtype: Link Rect: 168, 259, 185, 269 ActionDest: 607 Annotation: Subtype: Link Rect: 292, 402, 319, 411 ActionDest: 607 Annotation: Subtype: Link Rect: 210, 391, 226, 401 ActionDest: 607 Annotation: Subtype: Link Rect: 228, 391, 246, 401 ActionDest: 607 Annotation: Subtype: Link Rect: 405, 421, 432, 430 ActionDest: 607 Annotation: Subtype: Link Rect: 322, 412, 339, 420 ActionDest: 607 Annotation: Subtype: Link Rect: 341, 412, 358, 420 ActionDest: 607 Annotation: Subtype: Link Rect: 405, 393, 432, 401 ActionDest: 557 Annotation: Subtype: Link Rect: 322, 382, 339, 392 ActionDest: 557 Annotation: Subtype: Link Rect: 341, 382, 358, 392 ActionDest: 557 Annotation: Subtype: Link Rect: 360, 382, 401, 392 ActionDest: 557 Annotation: Subtype: Link Rect: 403, 382, 420, 392 ActionDest: 557 Annotation: Subtype: Link Rect: 111, 207, 156, 216 ActionDest: 557 Annotation: Subtype: Link Rect: 158, 207, 175, 216 ActionDest: 557 Annotation: Subtype: Link Rect: 177, 207, 206, 216 ActionDest: 607 Annotation: Subtype: Link Rect: 109, 198, 125, 206 ActionDest: 607 Annotation: Subtype: Link Rect: 127, 198, 145, 206 ActionDest: 607 Annotation: Subtype: Link Rect: 111, 159, 156, 168 ActionDest: 557 Annotation: Subtype: Link Rect: 158, 159, 175, 168 ActionDest: 557 Annotation: Subtype: Link Rect: 211, 225, 257, 235 ActionDest: 557 Annotation: Subtype: Link Rect: 259, 225, 276, 235 ActionDest: 557 Annotation: Subtype: Link Rect: 165, 145, 206, 155 ActionDest: 557 Annotation: Subtype: Link Rect: 109, 135, 125, 144 ActionDest: 557 Annotation: Subtype: Link Rect: 127, 135, 145, 144 ActionDest: 557 Annotation: Subtype: Link Rect: 111, 105, 164, 115 ActionDest: 557 Annotation: Subtype: Link Rect: 166, 105, 184, 115 ActionDest: 557 Annotation: Subtype: Link Rect: 241, 117, 279, 125 ActionDest: 607 Annotation: Subtype: Link Rect: 281, 117, 299, 125 ActionDest: 607 Annotation: Subtype: Link Rect: 210, 107, 253, 115 ActionDest: 607 Annotation: Subtype: Link Rect: 255, 107, 273, 115 ActionDest: 607 Annotation: Subtype: Link Rect: 210, 96, 280, 106 ActionDest: 557 Annotation: Subtype: Link Rect: 282, 96, 300, 106 ActionDest: 557 Annotation: Subtype: Link Rect: 324, 116, 395, 125 ActionDest: 557 Annotation: Subtype: Link Rect: 397, 116, 414, 125 ActionDest: 557 Annotation: Subtype: Link Rect: 322, 107, 360, 115 ActionDest: 557 Annotation: Subtype: Link Rect: 362, 107, 380, 115 ActionDest: 557 Annotation: Subtype: Link Rect: 382, 107, 432, 115 ActionDest: 557 Annotation: Subtype: Link Rect: 322, 96, 339, 106 ActionDest: 557 Annotation: Subtype: Link Rect: 341, 96, 358, 106 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 361, 628, 399, 638 ActionDest: 607 Annotation: Subtype: Link Rect: 401, 628, 419, 638 ActionDest: 607 Annotation: Subtype: Link Rect: 185, 595, 214, 604 ActionDest: 654 Annotation: Subtype: Link Rect: 116, 586, 132, 594 ActionDest: 654 Annotation: Subtype: Link Rect: 134, 586, 152, 594 ActionDest: 654 Annotation: Subtype: Link Rect: 151, 556, 187, 566 ActionDest: 557 Annotation: Subtype: Link Rect: 189, 556, 206, 566 ActionDest: 557 Annotation: Subtype: Link Rect: 254, 576, 298, 585 ActionDest: 607 Annotation: Subtype: Link Rect: 300, 576, 317, 585 ActionDest: 607 Annotation: Subtype: Link Rect: 307, 558, 322, 566 ActionDest: 654 Annotation: Subtype: Link Rect: 224, 547, 240, 556 ActionDest: 654 Annotation: Subtype: Link Rect: 242, 547, 260, 556 ActionDest: 654 Annotation: Subtype: Link Rect: 509, 567, 538, 575 ActionDest: 607 Annotation: Subtype: Link Rect: 440, 556, 456, 566 ActionDest: 607 Annotation: Subtype: Link Rect: 458, 556, 476, 566 ActionDest: 607 Annotation: Subtype: Link Rect: 173, 504, 214, 513 ActionDest: 607 Annotation: Subtype: Link Rect: 116, 495, 132, 503 ActionDest: 607 Annotation: Subtype: Link Rect: 134, 495, 152, 503 ActionDest: 607 Annotation: Subtype: Link Rect: 179, 476, 214, 484 ActionDest: 607 Annotation: Subtype: Link Rect: 116, 465, 132, 475 ActionDest: 607 Annotation: Subtype: Link Rect: 134, 465, 152, 475 ActionDest: 607 Annotation: Subtype: Link Rect: 255, 504, 299, 513 ActionDest: 607 Annotation: Subtype: Link Rect: 301, 504, 318, 513 ActionDest: 607 Annotation: Subtype: Link Rect: 249, 484, 292, 494 ActionDest: 607 Annotation: Subtype: Link Rect: 294, 484, 312, 494 ActionDest: 607 Annotation: Subtype: Link Rect: 374, 486, 411, 494 ActionDest: 607 Annotation: Subtype: Link Rect: 332, 475, 350, 484 ActionDest: 607 Annotation: Subtype: Link Rect: 118, 414, 163, 422 ActionDest: 557 Annotation: Subtype: Link Rect: 165, 414, 183, 422 ActionDest: 557 Annotation: Subtype: Link Rect: 118, 376, 161, 384 ActionDest: 607 Annotation: Subtype: Link Rect: 163, 376, 181, 384 ActionDest: 607 Annotation: Subtype: Link Rect: 118, 338, 154, 346 ActionDest: 557 Annotation: Subtype: Link Rect: 156, 338, 173, 346 ActionDest: 557 Annotation: Subtype: Link Rect: 248, 423, 285, 431 ActionDest: 607 Annotation: Subtype: Link Rect: 287, 423, 304, 431 ActionDest: 607 Annotation: Subtype: Link Rect: 334, 404, 371, 413 ActionDest: 557 Annotation: Subtype: Link Rect: 373, 404, 391, 413 ActionDest: 557 Annotation: Subtype: Link Rect: 393, 404, 421, 413 ActionDest: 654 Annotation: Subtype: Link Rect: 332, 393, 350, 403 ActionDest: 654 Annotation: Subtype: Link Rect: 351, 393, 392, 403 ActionDest: 557 Annotation: Subtype: Link Rect: 394, 393, 411, 403 ActionDest: 557 Annotation: Subtype: Link Rect: 118, 266, 154, 274 ActionDest: 557 Annotation: Subtype: Link Rect: 156, 266, 173, 274 ActionDest: 557 Annotation: Subtype: Link Rect: 183, 237, 214, 246 ActionDest: 607 Annotation: Subtype: Link Rect: 116, 228, 132, 236 ActionDest: 607 Annotation: Subtype: Link Rect: 134, 228, 152, 236 ActionDest: 607 Annotation: Subtype: Link Rect: 160, 200, 208, 208 ActionDest: 532 Annotation: Subtype: Link Rect: 116, 190, 134, 199 ActionDest: 532 Annotation: Subtype: Link Rect: 118, 171, 154, 180 ActionDest: 557 Annotation: Subtype: Link Rect: 156, 171, 173, 180 ActionDest: 557 Annotation: Subtype: Link Rect: 173, 143, 209, 151 ActionDest: 557 Annotation: Subtype: Link Rect: 116, 132, 134, 142 ActionDest: 557 Annotation: Subtype: Link Rect: 398, 304, 430, 312 ActionDest: 557 Annotation: Subtype: Link Rect: 332, 294, 348, 303 ActionDest: 557 Annotation: Subtype: Link Rect: 350, 294, 368, 303 ActionDest: 557 Annotation: Subtype: Link Rect: 370, 294, 410, 303 ActionDest: 557 Annotation: Subtype: Link Rect: 332, 283, 350, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 255, 694, 291, 705 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 682, 66, 694 ActionDest: 607 Annotation: Subtype: Link Rect: 70, 682, 91, 694 ActionDest: 607 Annotation: Subtype: Link Rect: 95, 682, 170, 694 ActionDest: 557 Annotation: Subtype: Link Rect: 174, 682, 194, 694 ActionDest: 557 Annotation: Subtype: Link Rect: 199, 682, 261, 694 ActionDest: 557 Annotation: Subtype: Link Rect: 265, 682, 285, 694 ActionDest: 557 Annotation: Subtype: Link Rect: 171, 591, 201, 602 ActionDest: 160 Annotation: Subtype: Link Rect: 47, 556, 98, 568 ActionDest: 607 Annotation: Subtype: Link Rect: 106, 556, 126, 568 ActionDest: 607 Annotation: Subtype: Link Rect: 76, 534, 125, 545 ActionDest: 607 Annotation: Subtype: Link Rect: 132, 534, 152, 545 ActionDest: 607 Annotation: Subtype: Link Rect: 235, 442, 289, 453 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 430, 64, 442 ActionDest: 557 Annotation: Subtype: Link Rect: 203, 407, 261, 419 ActionDest: 557 Annotation: Subtype: Link Rect: 268, 407, 289, 419 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 397, 103, 407 ActionDest: 557 Annotation: Subtype: Link Rect: 105, 397, 125, 407 ActionDest: 557 Annotation: Subtype: Link Rect: 162, 316, 237, 327 ActionDest: 557 Annotation: Subtype: Link Rect: 240, 316, 260, 327 ActionDest: 557 Annotation: Subtype: Link Rect: 264, 316, 291, 327 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 304, 66, 315 ActionDest: 557 Annotation: Subtype: Link Rect: 71, 304, 91, 315 ActionDest: 557 Annotation: Subtype: Link Rect: 96, 304, 144, 315 ActionDest: 607 Annotation: Subtype: Link Rect: 149, 304, 169, 315 ActionDest: 607 Annotation: Subtype: Link Rect: 87, 293, 167, 304 ActionDest: 557 Annotation: Subtype: Link Rect: 174, 293, 194, 304 ActionDest: 557 Annotation: Subtype: Link Rect: 200, 293, 259, 304 ActionDest: 557 Annotation: Subtype: Link Rect: 265, 293, 285, 304 ActionDest: 557 Annotation: Subtype: Link Rect: 211, 270, 289, 281 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 259, 64, 270 ActionDest: 557 Annotation: Subtype: Link Rect: 67, 259, 101, 270 ActionDest: 607 Annotation: Subtype: Link Rect: 103, 259, 124, 270 ActionDest: 607 Annotation: Subtype: Link Rect: 265, 259, 291, 270 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 247, 83, 258 ActionDest: 607 Annotation: Subtype: Link Rect: 86, 247, 106, 258 ActionDest: 607 Annotation: Subtype: Link Rect: 100, 235, 147, 247 ActionDest: 607 Annotation: Subtype: Link Rect: 152, 235, 172, 247 ActionDest: 607 Annotation: Subtype: Link Rect: 89, 178, 134, 189 ActionDest: 607 Annotation: Subtype: Link Rect: 138, 178, 158, 189 ActionDest: 607 Annotation: Subtype: Link Rect: 151, 156, 214, 167 ActionDest: 607 Annotation: Subtype: Link Rect: 216, 156, 237, 167 ActionDest: 607 Annotation: Subtype: Link Rect: 192, 133, 228, 144 ActionDest: 324 Annotation: Subtype: Link Rect: 112, 110, 191, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 194, 110, 214, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 47, 87, 82, 98 ActionDest: 324 Annotation: Subtype: Link Rect: 309, 439, 382, 447 ActionDest: 607 Annotation: Subtype: Link Rect: 383, 439, 405, 447 ActionDest: 607 Annotation: Subtype: Link Rect: 409, 410, 441, 419 ActionDest: 607 Annotation: Subtype: Link Rect: 443, 410, 460, 419 ActionDest: 607 Annotation: Subtype: Link Rect: 520, 339, 550, 350 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 327, 346, 338 ActionDest: 557 Annotation: Subtype: Link Rect: 348, 327, 368, 338 ActionDest: 557 Annotation: Subtype: Link Rect: 370, 327, 416, 338 ActionDest: 557 Annotation: Subtype: Link Rect: 418, 327, 438, 338 ActionDest: 557 Annotation: Subtype: Link Rect: 306, 316, 352, 327 ActionDest: 607 Annotation: Subtype: Link Rect: 356, 316, 376, 327 ActionDest: 607 Annotation: Subtype: Link Rect: 499, 293, 548, 304 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 281, 323, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 326, 281, 379, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 382, 281, 402, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 521, 270, 550, 281 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 259, 323, 270 ActionDest: 607 Annotation: Subtype: Link Rect: 325, 259, 345, 270 ActionDest: 607 Annotation: Subtype: Link Rect: 348, 259, 397, 270 ActionDest: 557 Annotation: Subtype: Link Rect: 399, 259, 419, 270 ActionDest: 557 Annotation: Subtype: Link Rect: 520, 190, 550, 201 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 178, 350, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 354, 178, 374, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 521, 121, 550, 132 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 110, 323, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 325, 110, 345, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 347, 110, 437, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 439, 110, 463, 121 ActionDest: 607 Annotation: Subtype: Link Rect: 498, 87, 550, 98 ActionDest: 557 Annotation: Subtype: Link Rect: 303, 75, 322, 86 ActionDest: 557 Annotation: Subtype: Link Rect: 324, 75, 344, 86 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 108, 682, 152, 694 ActionDest: 607 Annotation: Subtype: Link Rect: 156, 682, 176, 694 ActionDest: 607 Annotation: Subtype: Link Rect: 118, 659, 161, 671 ActionDest: 607 Annotation: Subtype: Link Rect: 164, 659, 184, 671 ActionDest: 607 Annotation: Subtype: Link Rect: 71, 648, 164, 659 ActionDest: 607 Annotation: Subtype: Link Rect: 167, 648, 192, 659 ActionDest: 607 Annotation: Subtype: Link Rect: 121, 614, 190, 625 ActionDest: 607 Annotation: Subtype: Link Rect: 192, 614, 212, 625 ActionDest: 607 Annotation: Subtype: Link Rect: 260, 568, 291, 579 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 556, 93, 568 ActionDest: 557 Annotation: Subtype: Link Rect: 97, 556, 118, 568 ActionDest: 557 Annotation: Subtype: Link Rect: 47, 499, 95, 510 ActionDest: 557 Annotation: Subtype: Link Rect: 98, 499, 118, 510 ActionDest: 557 Annotation: Subtype: Link Rect: 260, 430, 291, 442 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 420, 93, 430 ActionDest: 557 Annotation: Subtype: Link Rect: 98, 420, 119, 430 ActionDest: 557 Annotation: Subtype: Link Rect: 124, 420, 170, 430 ActionDest: 607 Annotation: Subtype: Link Rect: 175, 420, 195, 430 ActionDest: 607 Annotation: Subtype: Link Rect: 47, 396, 121, 407 ActionDest: 557 Annotation: Subtype: Link Rect: 124, 396, 144, 407 ActionDest: 557 Annotation: Subtype: Link Rect: 47, 374, 106, 384 ActionDest: 557 Annotation: Subtype: Link Rect: 108, 374, 129, 384 ActionDest: 557 Annotation: Subtype: Link Rect: 139, 304, 219, 315 ActionDest: 557 Annotation: Subtype: Link Rect: 225, 304, 245, 315 ActionDest: 557 Annotation: Subtype: Link Rect: 235, 281, 289, 293 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 270, 64, 281 ActionDest: 557 Annotation: Subtype: Link Rect: 67, 270, 120, 281 ActionDest: 557 Annotation: Subtype: Link Rect: 123, 270, 144, 281 ActionDest: 557 Annotation: Subtype: Link Rect: 211, 235, 289, 247 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 224, 64, 235 ActionDest: 557 Annotation: Subtype: Link Rect: 70, 178, 148, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 152, 178, 173, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 177, 178, 229, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 234, 178, 254, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 259, 178, 291, 189 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 167, 69, 178 ActionDest: 557 Annotation: Subtype: Link Rect: 76, 167, 96, 178 ActionDest: 557 Annotation: Subtype: Link Rect: 405, 568, 452, 579 ActionDest: 607 Annotation: Subtype: Link Rect: 454, 568, 474, 579 ActionDest: 607 Annotation: Subtype: Link Rect: 345, 156, 393, 167 ActionDest: 557 Annotation: Subtype: Link Rect: 396, 156, 416, 167 ActionDest: 557 Annotation: Subtype: Link Rect: 395, 98, 430, 109 ActionDest: 459 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 93, 490, 137, 500 ActionDest: 557 Annotation: Subtype: Link Rect: 139, 490, 159, 500 ActionDest: 557 Annotation: Subtype: Link Rect: 162, 490, 224, 500 ActionDest: 557 Annotation: Subtype: Link Rect: 226, 490, 246, 500 ActionDest: 557 Annotation: Subtype: Link Rect: 47, 467, 110, 477 ActionDest: 557 Annotation: Subtype: Link Rect: 112, 467, 133, 477 ActionDest: 557 Annotation: Subtype: Link Rect: 228, 467, 289, 477 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 455, 64, 466 ActionDest: 557 Annotation: Subtype: Link Rect: 250, 444, 291, 455 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 432, 66, 443 ActionDest: 557 Annotation: Subtype: Link Rect: 70, 432, 90, 443 ActionDest: 557 Annotation: Subtype: Link Rect: 94, 329, 151, 340 ActionDest: 607 Annotation: Subtype: Link Rect: 155, 329, 175, 340 ActionDest: 607 Annotation: Subtype: Link Rect: 205, 271, 263, 283 ActionDest: 557 Annotation: Subtype: Link Rect: 265, 271, 285, 283 ActionDest: 557 Annotation: Subtype: Link Rect: 239, 168, 289, 180 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 157, 64, 168 ActionDest: 607 Annotation: Subtype: Link Rect: 91, 65, 148, 76 ActionDest: 607 Annotation: Subtype: Link Rect: 152, 65, 172, 76 ActionDest: 607 Annotation: Subtype: Link Rect: 347, 489, 382, 500 ActionDest: 459 Annotation: Subtype: Link Rect: 419, 466, 464, 477 ActionDest: 557 Annotation: Subtype: Link Rect: 467, 466, 488, 477 ActionDest: 557 Annotation: Subtype: Link Rect: 306, 443, 351, 455 ActionDest: 654 Annotation: Subtype: Link Rect: 354, 443, 374, 455 ActionDest: 654 Annotation: Subtype: Link Rect: 429, 70, 474, 79 ActionDest: 607 Annotation: Subtype: Link Rect: 475, 70, 493, 79 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 174, 328, 223, 340 ActionDest: 607 Annotation: Subtype: Link Rect: 225, 328, 245, 340 ActionDest: 607 Annotation: Subtype: Link Rect: 179, 295, 237, 305 ActionDest: 607 Annotation: Subtype: Link Rect: 242, 295, 262, 305 ActionDest: 607 Annotation: Subtype: Link Rect: 134, 260, 199, 271 ActionDest: 607 Annotation: Subtype: Link Rect: 204, 260, 224, 271 ActionDest: 607 Annotation: Subtype: Link Rect: 228, 225, 289, 236 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 214, 64, 225 ActionDest: 557 Annotation: Subtype: Link Rect: 237, 179, 289, 191 ActionDest: 607 Annotation: Subtype: Link Rect: 44, 168, 64, 179 ActionDest: 607 Annotation: Subtype: Link Rect: 136, 156, 189, 168 ActionDest: 557 Annotation: Subtype: Link Rect: 192, 156, 212, 168 ActionDest: 557 Annotation: Subtype: Link Rect: 77, 122, 132, 133 ActionDest: 607 Annotation: Subtype: Link Rect: 136, 122, 156, 133 ActionDest: 607 Annotation: Subtype: Link Rect: 306, 363, 360, 374 ActionDest: 607 Annotation: Subtype: Link Rect: 363, 363, 383, 374 ActionDest: 607 Annotation: Subtype: Link Rect: 527, 340, 550, 351 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 328, 323, 340 ActionDest: 607 Annotation: Subtype: Link Rect: 326, 328, 346, 340 ActionDest: 607 Annotation: Subtype: Link Rect: 529, 179, 550, 191 ActionDest: 607 Annotation: Subtype: Link Rect: 303, 168, 325, 179 ActionDest: 607 Annotation: Subtype: Link Rect: 329, 168, 349, 179 ActionDest: 607 Annotation: Subtype: Link Rect: 429, 156, 466, 168 ActionDest: 499 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 231, 682, 289, 694 ActionDest: 557 Annotation: Subtype: Link Rect: 44, 671, 64, 682 ActionDest: 557 Annotation: Subtype: Link Rect: 68, 671, 120, 682 ActionDest: 557 Annotation: Subtype: Link Rect: 123, 671, 144, 682 ActionDest: 557 Annotation: Subtype: Link Rect: 103, 591, 156, 602 ActionDest: 607 Annotation: Subtype: Link Rect: 158, 591, 179, 602 ActionDest: 607 Annotation: Subtype: Link Rect: 208, 350, 262, 361 ActionDest: 557 Annotation: Subtype: Link Rect: 267, 350, 287, 361 ActionDest: 557 Annotation: Subtype: Link Rect: 47, 259, 95, 270 ActionDest: 607 Annotation: Subtype: Link Rect: 98, 259, 118, 270 ActionDest: 607 Annotation: Subtype: Link Rect: 359, 659, 408, 670 ActionDest: 607 Annotation: Subtype: Link Rect: 412, 659, 432, 670 ActionDest: 607 Annotation: Subtype: Link Rect: 365, 647, 415, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 418, 647, 438, 659 ActionDest: 557 Annotation: Subtype: Link Rect: 401, 625, 444, 636 ActionDest: 557 Annotation: Subtype: Link Rect: 446, 625, 466, 636 ActionDest: 557 Annotation: Subtype: Link Rect: 82, 85, 178, 94 Annotation: Subtype: Link Rect: 388, 123, 486, 132 Annotation: Subtype: Link Rect: 313, 87, 391, 94 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 245, 706, 291, 715 Annotation: Subtype: Link Rect: 52, 697, 84, 705 Annotation: Subtype: Link Rect: 231, 668, 291, 677 Annotation: Subtype: Link Rect: 52, 660, 81, 667 Annotation: Subtype: Link Rect: 54, 622, 155, 630 Annotation: Subtype: Link Rect: 100, 593, 235, 601 Annotation: Subtype: Link Rect: 79, 545, 158, 554 Annotation: Subtype: Link Rect: 213, 507, 291, 516 Annotation: Subtype: Link Rect: 52, 498, 80, 506 Annotation: Subtype: Link Rect: 54, 450, 147, 459 Annotation: Subtype: Link Rect: 247, 423, 291, 431 Annotation: Subtype: Link Rect: 52, 414, 82, 421 Annotation: Subtype: Link Rect: 160, 384, 223, 393 Annotation: Subtype: Link Rect: 234, 346, 291, 355 Annotation: Subtype: Link Rect: 52, 338, 77, 346 Annotation: Subtype: Link Rect: 226, 299, 291, 308 Annotation: Subtype: Link Rect: 52, 291, 91, 298 Annotation: Subtype: Link Rect: 82, 261, 154, 270 Annotation: Subtype: Link Rect: 54, 224, 167, 232 Annotation: Subtype: Link Rect: 54, 187, 121, 194 Annotation: Subtype: Link Rect: 106, 147, 200, 157 Annotation: Subtype: Link Rect: 121, 109, 201, 119 Annotation: Subtype: Link Rect: 133, 73, 204, 81 Annotation: Subtype: Link Rect: 458, 687, 529, 696 Annotation: Subtype: Link Rect: 474, 649, 550, 658 Annotation: Subtype: Link Rect: 311, 641, 335, 648 Annotation: Subtype: Link Rect: 490, 602, 550, 611 Annotation: Subtype: Link Rect: 311, 594, 340, 601 Annotation: Subtype: Link Rect: 335, 554, 431, 564 Annotation: Subtype: Link Rect: 506, 526, 550, 535 Annotation: Subtype: Link Rect: 311, 518, 341, 526 Annotation: Subtype: Link Rect: 349, 479, 418, 488 Annotation: Subtype: Link Rect: 313, 442, 396, 450 Annotation: Subtype: Link Rect: 313, 403, 403, 412 Annotation: Subtype: Link Rect: 384, 366, 487, 374 Annotation: Subtype: Link Rect: 355, 329, 472, 336 Annotation: Subtype: Link Rect: 405, 290, 489, 299 Annotation: Subtype: Link Rect: 336, 253, 417, 261 Annotation: Subtype: Link Rect: 370, 223, 471, 232 Annotation: Subtype: Link Rect: 447, 195, 548, 204 Annotation: Subtype: Link Rect: 431, 158, 511, 166 Annotation: Subtype: Link Rect: 336, 130, 434, 138 Annotation: Subtype: Link Rect: 505, 100, 550, 109 Annotation: Subtype: Link Rect: 311, 91, 362, 100 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 54, 696, 157, 706 Annotation: Subtype: Link Rect: 54, 658, 123, 668 Annotation: Subtype: Link Rect: 77, 613, 156, 620 Annotation: Subtype: Link Rect: 246, 583, 291, 592 Annotation: Subtype: Link Rect: 52, 575, 105, 583 Annotation: Subtype: Link Rect: 54, 516, 132, 526 Annotation: Subtype: Link Rect: 233, 479, 291, 488 Annotation: Subtype: Link Rect: 52, 471, 79, 478 Annotation: Subtype: Link Rect: 118, 432, 195, 441 Annotation: Subtype: Link Rect: 247, 393, 291, 403 Annotation: Subtype: Link Rect: 52, 386, 77, 392 Annotation: Subtype: Link Rect: 82, 356, 178, 365 Annotation: Subtype: Link Rect: 54, 308, 148, 318 Annotation: Subtype: Link Rect: 233, 270, 291, 280 Annotation: Subtype: Link Rect: 52, 263, 77, 270 Annotation: Subtype: Link Rect: 54, 224, 146, 232 Annotation: Subtype: Link Rect: 54, 185, 144, 194 Annotation: Subtype: Link Rect: 233, 147, 291, 157 Annotation: Subtype: Link Rect: 52, 140, 77, 147 Annotation: Subtype: Link Rect: 54, 92, 152, 100 Annotation: Subtype: Link Rect: 382, 696, 477, 706 Annotation: Subtype: Link Rect: 412, 658, 483, 668 Annotation: Subtype: Link Rect: 502, 630, 550, 639 Annotation: Subtype: Link Rect: 311, 622, 338, 629 Annotation: Subtype: Link Rect: 313, 584, 394, 592 Annotation: Subtype: Link Rect: 462, 554, 550, 564 Annotation: Subtype: Link Rect: 311, 545, 342, 554 Annotation: Subtype: Link Rect: 360, 508, 447, 516 Annotation: Subtype: Link Rect: 342, 461, 445, 469 Annotation: Subtype: Link Rect: 313, 412, 392, 422 Annotation: Subtype: Link Rect: 492, 374, 550, 384 Annotation: Subtype: Link Rect: 311, 367, 338, 374 Annotation: Subtype: Link Rect: 389, 337, 460, 346 Annotation: Subtype: Link Rect: 505, 308, 550, 318 Annotation: Subtype: Link Rect: 311, 301, 364, 308 Annotation: Subtype: Link Rect: 359, 261, 439, 270 Annotation: Subtype: Link Rect: 500, 233, 550, 242 Annotation: Subtype: Link Rect: 311, 225, 342, 232 Annotation: Subtype: Link Rect: 342, 149, 427, 157 Annotation: Subtype: Link Rect: 313, 111, 400, 119 Annotation: Subtype: Link Rect: 313, 72, 425, 81 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 54, 679, 125, 687 Annotation: Subtype: Link Rect: 186, 649, 269, 658 Annotation: Subtype: Link Rect: 54, 621, 125, 630 Annotation: Subtype: Link Rect: 373, 658, 521, 668 Annotation: Subtype: Link Rect: 44, 30, 146, 39 Annotation: Subtype: Link Rect: 152, 30, 212, 39 Annotation: Subtype: Link Rect: 415, 30, 550, 39 Checksum: efa37f6d Type: CRC32 Checksum: 36e2f02ba61febc7e41fd0f96dfd28a0 Type: MD5 Checksum: dbaab6413242244891c0c2c059929c18fd84b4a1 Type: SHA-1 Checksum: 554b88e7ebeb31b23d349b5cc107ca381a69c97c295dacb12f43c037bcc8d2d4 Type: SHA-256