8572bbe176f84728a2ff425def7d9271 pmc_33552054.pdf 4afc83437c46e93e230253c1daf472e1fbf0aea8 pmc_33552054.pdf 5df2632973100a72a0de61858dfc46f7ad0c44d584cbbe0115725de182ffb58a pmc_33552054.pdf Title: Vitamin D3-Induced Tolerogenic Dendritic Cells Modulate the Transcriptomic Profile of T CD4+ Cells Towards a Functional Hyporesponsiveness Subject: The use of autologous tolerogenic dendritic cells (tolDC) has become a promising alternative for the treatment of autoimmune diseases Keywords: tolerogenic dendritic cells, immune tolerance, T cells, antigen-specific response, transcriptomic study Author: Juan Navarro-Barriuso Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Jan 18 13:31:40 2021 CET ModDate: Mon Jan 18 13:58:49 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1350869 bytes Optimized: no PDF version: 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indirect destination - referenced object 'B40' cannot be found Offset: 1327263 MIMEtype: application/pdf PDFMetadata: Objects: 1213 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Sample Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Monocyte Isolation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: TT-Loaded DC Cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Autologous PBMC Isolation, Co-Culture, and Sorting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Phenotype Characterization of DC and Autologous PBMC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Allogeneic and Autologous Cell Proliferation Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Cytokine and Soluble Protein Production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: RNA Extraction and RNA-seq Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Differential Gene Expression Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Gene Ontology Enrichment Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: Functional and Phenotypical Characteristics of TT-Loaded vitD3-tolDC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: VitD3-tolDC-TT Induce an Antigen-Specific Response Over Autologous PBMC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: VitD3-tolDC-TT Drive a Reduction of TH1 CD4+ Cell Subpopulations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: VitD3-tolDC Induce a General Transcriptomic Repression Over T CD4+ Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: VitD3-tolDC Induce a General Transcriptomic Repression Over T CD4+ Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: VitD3-Tcell Present Decreased Cell Cycle and Mitotic Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Info: Title: Vitamin D3-Induced Tolerogenic Dendritic Cells Modulate the Transcriptomic Profile of 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Advanced Print Publisher 10.0.1306/W Unicode 2021-01-18T20:58:49+08:00 application/pdf Vitamin D3-Induced Tolerogenic Dendritic Cells Modulate the Transcriptomic Profile of T CD4+ Cells Towards a Functional Hyporesponsiveness Juan Navarro-Barriuso Mar&iacute a José Mansilla Bibiana Quirant-Sánchez Aina Teniente-Serra Cristina Ramo-Tello Eva M. Mart&iacute nez-Cáceres The use of autologous tolerogenic dendritic cells (tolDC) has become a promising alternative for the treatment of autoimmune diseases tolerogenic dendritic cells immune tolerance T cells antigen-specific response transcriptomic study uuid:179120cf-7ff8-4142-b23e-f95abd2f61d9 uuid:937d98ef-4c84-4973-9ce2-bc57a04b291c Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 606, 495, 627 Annotation: Subtype: Link Rect: 175, 583, 458, 604 Annotation: Subtype: Link Rect: 175, 569, 500, 590 Annotation: Subtype: Link Rect: 175, 537, 445, 558 Annotation: Subtype: Link Rect: 175, 514, 381, 535 Annotation: Subtype: Link Rect: 529, 75, 534, 85 Destination: 161 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 416, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 494, 158, 502 Annotation: Subtype: Link Rect: 47, 285, 158, 292 Annotation: Subtype: Link Rect: 57, 64, 158, 71 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