5a82f95d9627db1b5bac3cb72fec7b1d pmc_33578870.pdf bab94dbfdd86ac5b3bfaee57453e2df585e06105 pmc_33578870.pdf c990f0e93181852fe0a04f904bb2defca2270dab868f3a83778d3d1e6a7ea79d pmc_33578870.pdf Title: Endogenous Mechanisms of Neuroprotection: To Boost or Not to Be Subject: Postmitotic cells, like neurons, must live through a lifetime. For this reason, organisms/cells have evolved with self-repair mechanisms that allow them to have a long life. The discovery workflow of neuroprotectors during the last years has focused on blocking the pathophysiological mechanisms that lead to neuronal loss in neurodegeneration. Unfortunately, only a few strategies from these studies were able to slow down or prevent neurodegeneration. There is compelling evidence demonstrating that endorsing the self-healing mechanisms that organisms/cells endogenously have, commonly referred to as cellular resilience, can arm neurons and promote their self-healing. Although enhancing these mechanisms has not yet received sufficient attention, these pathways open up new therapeutic avenues to prevent neuronal death and ameliorate neurodegeneration. Here, we highlight the main endogenous mechanisms of protection and describe their role in promoting neuron survival during neurodegeneration. Keywords: autophagy; cellular resilience; endogenous mechanisms; neuroprotection; neuronal survival; unfolded protein response Author: Sara Marmolejo-Martínez-Artesero, Caty Casas and David Romeo-Guitart Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Feb 20 03:32:13 2021 CET ModDate: Mon Feb 22 02:33:55 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 450333 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DQHEJR+VnURWPalladioL Type 1 Custom yes yes no 10 0 IJAGHH+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 SBLOCE+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 HFUNWI+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 PFKOHU+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 NTEYOL+EURM10 Type 1 Builtin yes yes no 78 0 FXXUVH+CMSY10 Type 1 Builtin yes yes no 94 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:30:56 CEST RepresentationInformation: pmc_33578870.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:08:53 CEST Size: 450333 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 730 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Neurodegenerative Processes Destination: section.1 Item: Title: First Evidence of Endogenous Mechanisms: Pre-Conditioning Destination: section.2 Item: Title: Endogenous Mechanisms of Neuroprotection Destination: section.3 Children: Item: Title: Fine-Tuning Autophagy Destination: subsection.3.1 Item: Title: Tackling the Sexy Part of Unfolded Protein Response Destination: subsection.3.2 Item: Title: “Not Today” Apoptosis Destination: subsection.3.3 Item: Title: Reattaching by Anti-Anoikis Destination: subsection.3.4 Item: Title: Cytoskeleton and Motor Transporters Destination: subsection.3.5 Item: Title: Mitochondrial Well-Function Destination: subsection.3.6 Item: Title: Targeting Systemic Modulation Destination: section.4 Children: Item: Title: Caloric Restriction Destination: subsection.4.1 Item: Title: Exercise Destination: subsection.4.2 Item: Title: Finding Effective Neuroprotectant: What There Is and Where We Go Destination: section.5 Item: Title: Concluding Remarks Destination: section.6 Item: Title: References Destination: section.6 Info: Title: Endogenous Mechanisms of Neuroprotection: To Boost or Not to Be Author: Sara Marmolejo-Martínez-Artesero, Caty Casas and David Romeo-Guitart Subject: Postmitotic cells, like neurons, must live through a lifetime. For this reason, organisms/cells have evolved with self-repair mechanisms that allow them to have a long life. The discovery workflow of neuroprotectors during the last years has focused on blocking the pathophysiological mechanisms that lead to neuronal loss in neurodegeneration. Unfortunately, only a few strategies from these studies were able to slow down or prevent neurodegeneration. There is compelling evidence demonstrating that endorsing the self-healing mechanisms that organisms/cells endogenously have, commonly referred to as cellular resilience, can arm neurons and promote their self-healing. Although enhancing these mechanisms has not yet received sufficient attention, these pathways open up new therapeutic avenues to prevent neuronal death and ameliorate neurodegeneration. Here, we highlight the main endogenous mechanisms of protection and describe their role in promoting neuron survival during neurodegeneration. 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