590ae731d1d420ce7e64d91d32ee87a8 pmc_33578924.pdf 6e509ce42745ca150eece6970ff4d157bbd26742 pmc_33578924.pdf affef17ec03ad81783106fc646a3bf4482ee905273e12e1997713b0347ede4e8 pmc_33578924.pdf Title: Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms Subject: Arterial stiffness (AS) is an independent predictor of cardiovascular risk. We aimed to analyze changes () in AS 1-month post-bariatric surgery (BS) and search for possible pathophysiological mechanisms. Patients with severe obesity (43% hypertensives) were prospectively evaluated before and 1-month post-BS, with AS assessed by pulse-wave velocity (PWV), augmentation index (AIx@75) and pulse pressure (PP). Ambulatory 24 h blood pressure (BP), anthropometric data, renin-angiotensin-aldosterone system (RAAS) components and several adipokines and inflammatory markers were also analyzed. Overall reduction in body weight was mean (interquartile range (IQR)) = 11.0% (9.6–13.1). A decrease in PWV, AIx@75 and PP was observed 1-month post-BS (all, p < 0.01). There were also significant in BP, RAAS components, adipokines and inflammatory biomarkers. Multiple linear regression adjusted models showed that aldosterone was an independent variable (B coeff.95%CI) for final PWV (B = -0.003, -0.005 to 0.000; p = 0.022). Angiotensin-converting enzyme (ACE)/ACE2 and ACE were independent variables for final AIx@75 (B = 0.036, 0.005 to 0.066; p = 0.024) and PP (B = 0.010, 0.003 to 0.017; p = 0.01), respectively. There was no correlation between AS and anthropometric changes nor with of adipokines or inflammatory markers except high-sensitivity C-reactive protein (hs-CRP). Patients with PWV below median decreased PWV (mean, 95%CI = -0.18, -0.25 to -0.10; p < 0.001) and both AIx@75 and PP at 1-month, but not those with PWV above median. In conclusion, there is an improvement in AS 1-month post-BS that correlates with BP and renin-angiotensin-aldosterone components. The benefit is reduced in those with higher PWV. Keywords: bariatric surgery; arterial stiffness; renin-angiotensin axis Author: Anna Oliveras, Isabel Galceran, Albert Goday, Susana Vázquez, Laia Sans, Marta Riera, David Benaiges and Julio Pascual Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Feb 20 04:55:41 2021 CET ModDate: Sat Feb 20 05:01:26 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 522133 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HCBGQO+VnURWPalladioL Type 1 Custom yes yes no 10 0 KXNUUD+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 ZMBGKP+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 JHWCTB+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 28 0 NTJMOU+CMSY10 Type 1 Builtin yes yes no 32 0 AIQCCL+VnURWPalladioL-Bold Type 1 Custom yes yes no 36 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 44 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 47 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 69 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 73 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 77 0 REGJRM+EURM10 Type 1 Builtin yes yes no 95 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 102 0 NOAJDE+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 122 0 NOAJEF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 128 0 NOAJEG+PalatinoLinotype CID TrueType Identity-H yes yes yes 131 0 NOAJEH+PalatinoLinotype TrueType WinAnsi yes yes no 137 0 NOAJEJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 140 0 NOALIN+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 143 0 PDXFNG+PazoMath-Bold Type 1 Builtin yes yes no 150 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-21 02:38:58 CEST RepresentationInformation: pmc_33578924.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:08:53 CEST Size: 522133 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 330 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: Study Design and Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Changes in Anthropometric and Hemodynamic Parameters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Changes in Glucose Metabolism, RAAS Components, Adipokines and Inflammatory Markers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Correlations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Children: Item: Title: Correlations of Changes in Arterial Stiffness (AS) with Changes in Anthropometric Parameters, Glucose Metabolism, Adipokines and Inflammatory Markers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Correlations of Changes in AS with Changes in BP Estimates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Correlations of Changes in AS with Changes in the RAAS Components Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Info: Title: Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms Author: Anna Oliveras, Isabel Galceran, Albert Goday, Susana Vázquez, Laia Sans, Marta Riera, David Benaiges and Julio Pascual Subject: Arterial stiffness (AS) is an independent predictor of cardiovascular risk. We aimed to analyze changes () in AS 1-month post-bariatric surgery (BS) and search for possible pathophysiological mechanisms. Patients with severe obesity (43% hypertensives) were prospectively evaluated before and 1-month post-BS, with AS assessed by pulse-wave velocity (PWV), augmentation index (AIx@75) and pulse pressure (PP). Ambulatory 24 h blood pressure (BP), anthropometric data, renin-angiotensin-aldosterone system (RAAS) components and several adipokines and inflammatory markers were also analyzed. Overall reduction in body weight was mean (interquartile range (IQR)) = 11.0% (9.6 13.1). A decrease in PWV, AIx@75 and PP was observed 1-month post-BS (all, p < 0.01). There were also significant in BP, RAAS components, adipokines and inflammatory biomarkers. Multiple linear regression adjusted models showed that aldosterone was an independent variable (B coeff.95%CI) for final PWV (B = -0.003, -0.005 to 0.000; p = 0.022). Angiotensin-converting enzyme (ACE)/ACE2 and ACE were independent variables for final AIx@75 (B = 0.036, 0.005 to 0.066; p = 0.024) and PP (B = 0.010, 0.003 to 0.017; p = 0.01), respectively. There was no correlation between AS and anthropometric changes nor with of adipokines or inflammatory markers except high-sensitivity C-reactive protein (hs-CRP). Patients with PWV below median decreased PWV (mean, 95%CI = -0.18, -0.25 to -0.10; p < 0.001) and both AIx@75 and PP at 1-month, but not those with PWV above median. In conclusion, there is an improvement in AS 1-month post-BS that correlates with BP and renin-angiotensin-aldosterone components. The benefit is reduced in those with higher PWV. 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