d9308d1d1072c92fb1a9edd22dcca4f6 pmc_33613490.pdf 0bb002171947278d604a8697ac496e73e935a58f pmc_33613490.pdf 0811c064962ef692e6bcfe3d507bd2cf0cdf6bbc21ac62aced9ca7c94d855315 pmc_33613490.pdf Title: Evaluation of an O2-Substituted (1–3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn’s Disease Subject: 1,3-β-glucans are extracellular polysaccharides synthesized by microorganisms and plants, with therapeutic potential. Author: Alicia Prieto and Paloma López Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Sat Jan 30 14:45:30 2021 CET ModDate: Sat Jan 30 14:45:40 2021 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 1613371 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FTSNZI+HelveticaNeueLTStd-Lt Type 1C Custom yes yes yes 9 0 EUDHLK+HelveticaNeueLTStd-Bd Type 1C Custom yes yes yes 10 0 DQTBXM+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes yes 109 0 CREVJO+HelveticaNeueLTStd-LtIt Type 1C WinAnsi yes yes yes 131 0 BNPPVQ+STIXGeneral-Regular Type 1C Custom yes yes yes 12 0 AOFJHS+STIXGeneral-Bold Type 1C Custom yes yes yes 110 0 ZKQDTU+HelveticaNeueLTStd-MdIt Type 1C Custom yes yes yes 1544 0 YLBXFW+MinionPro-Regular Type 1C Custom yes yes yes 11 0 WICLDA+MinionPro-It Type 1C Custom yes yes yes 13 0 FTSNZI+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 463 0 BNPPVQ+STIXGeneral-Regular Type 1C Custom yes yes yes 450 0 UFDZBE+MinionPro-Bold Type 1C Custom yes yes yes 73 0 FTSNZI+HelveticaNeueLTStd-Lt Type 1C WinAnsi yes yes yes 490 0 BNPPVQ+STIXGeneral-Regular Type 1C Custom yes yes yes 491 0 TBOTNG+STIXGeneral-BoldItalic Type 1C Custom yes yes yes 108 0 SCENZI+Arial-BoldMT Type 1C WinAnsi yes yes no 130 0 SCENZI+STIXGeneral-Italic Type 1C Custom yes yes yes 157 0 SCENZI+Arial-BoldMT Type 1C WinAnsi yes yes no 185 0 SCENZI+Arial-BoldMT Type 1C WinAnsi yes yes no 220 0 RYPHLK+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 295 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:45:36 CEST RepresentationInformation: pmc_33613490.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-03-08 03:36:24 CET Size: 1613371 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1604 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Evaluation of an O 2-Substituted (1–3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn’s Disease Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Patients Item: Title: EPS P and EPS L Production and Purification Item: Title: Organ Culture of Human Colonic Mucosa Item: Title: Determination of Cytokine Levels by Elisa Item: Title: Gene Expression Profiling Under EPS Treatment Item: Title: Transcription Factor Signaling Pathways NF κ B RNA Array Item: Title: Bioinformatic Functional Analysis Item: Title: Statistical Analysis Item: Title: Results and Discussion Children: Item: Title: Effect of O 2-Substituted-(1–3)-β-D-Glucans on Cytokine Production in ex vivo Models Item: Title: Effect of O 2-Substituted-(1–3)-β-D – Glucans on Gene Expression Profiling in ex vivo Model Item: Title: Effect of EPS L and EPS P on the NF κ B Gene Expression Profile of CD Patient Biopsy Item: Title: Functional Analysis With David Bioinformatic Resources Item: Title: Conclusion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Suppleme ntary Material Item: Title: References Info: Title: Evaluation of an O2-Substituted (1–3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn’s Disease Author: Alicia Prieto and Paloma López Subject: 1,3-β-glucans are extracellular polysaccharides synthesized by microorganisms and plants, with therapeutic potential. 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