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Keywords: regenerative cuff electrodes, low-cost fabrication, inkjet printing, wrinkling, organic bioelectronics, PEDOT:PSS, peripheral nerve interfaces Author: Francesco Greco and Jaume del Valle Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Feb 3 09:08:33 2021 CET ModDate: Wed Feb 3 10:31:54 2021 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 11151510 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JUTPWU+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 37 0 XKDTXP+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 42 0 GCDRPR+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 55 0 MFRGPJ+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 57 0 XPPFGS+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 63 0 KCXCAZ+MinionPro-Regular Type 1C Custom yes yes no 65 0 MDEJGH+MTSY Type 1C Custom yes yes yes 107 0 UMGKIK+MTGU Type 1C Custom yes yes yes 109 0 ZRUDTN+MinionPro-It Type 1C WinAnsi yes yes no 180 0 UTAJUA+MinionPro-Bold Type 1C Custom yes yes no 183 0 FKJARM+HelveticaNeueLTStd-Md Type 1C WinAnsi yes yes no 231 0 IYEFRP+RMTMI Type 1C Custom yes yes yes 248 0 QUQXBG+RMTMIB Type 1C Custom yes yes no 286 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:29:29 CEST RepresentationInformation: pmc_33644015.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:00 CEST Size: 11151510 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 542 FreeObjects: 19 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Materials and Methods Destination: section*.3 Children: Item: Title: Regenerative Nerve Cuff Electrode (RnCE) Fabrication Destination: section*.4 Item: Title: RnCE Surface and Electrical Characterization Destination: section*.5 Item: Title: In vivo Implantation Destination: section*.6 Item: Title: Evaluation of Axonal Regeneration Destination: section*.7 Children: Item: Title: Assessment of Motor Reinnervation Destination: section*.8 Item: Title: Assessment of Skin Sensory Reinnervation Destination: section*.9 Item: Title: Histology of Regenerated Sciatic Nerve Destination: section*.10 Item: Title: Electrophysiological Tests Destination: section*.11 Item: Title: Data Analysis Destination: section*.12 Item: Title: Results Destination: section*.13 Children: Item: Title: RnCEs Fabrication Strategy Destination: section*.14 Item: Title: RnCEs Surface and Electrical Characterization Destination: section*.15 Item: Title: Regeneration After Nerve Section and Repair Destination: section*.16 Item: Title: In vivo Assessment of RnCE Functionality Destination: section*.17 Item: Title: Discussion Destination: section*.18 Item: Title: Data Availability Statement Destination: section*.19 Item: Title: Ethics Statement Destination: section*.20 Item: Title: Author Contributions Destination: section*.21 Item: Title: Funding Destination: section*.22 Item: Title: Acknowledgments Destination: section*.23 Item: Title: Supplementary Material Destination: section*.24 Item: Title: References Destination: section*.25 Info: Title: All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes Author: Francesco Greco and Jaume del Valle Subject: Neural regeneration after lesions is still limited by several factors and new technologies are developed to address this issue. Keywords: regenerative cuff electrodes, low-cost fabrication, inkjet printing, wrinkling, organic bioelectronics, PEDOT:PSS, peripheral nerve interfaces Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Feb 03 09:38:33 CET 2021 ModDate: Wed Feb 03 11:01:54 CET 2021 ID: 0x6d911eb450ac20c209822cad99c7ab54, 0x433ad9d9ed64ff40b403ff8b18a742ea Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3780 ImageHeight: 6003 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3780 ImageHeight: 3317 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: 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Francesco Greco and Jaume del Valle All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes regenerative cuff electrodes low-cost fabrication inkjet printing wrinkling organic bioelectronics PEDOT:PSS peripheral nerve interfaces regenerative cuff electrodes, low-cost fabrication, inkjet printing, wrinkling, organic bioelectronics, PEDOT:PSS, peripheral nerve interfaces dvips + MiKTeX GPL Ghostscript 9.0 uuid:2239e082-0eb1-4ec4-93d6-f841f0ba9318 uuid:15bb488e-e93f-4532-b3a2-737388bd0568 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 290, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 463, 728, 505, 736 Annotation: Subtype: Link Rect: 505, 728, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 183, 38 Annotation: Subtype: Link Rect: 186, 30, 246, 38 Annotation: 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External Annotation: Subtype: Link Rect: 491, 147, 549, 158 Destination: External Annotation: Subtype: Link Rect: 304, 136, 324, 147 Destination: External Annotation: Subtype: Link Rect: 328, 136, 388, 147 Destination: External Annotation: Subtype: Link Rect: 391, 136, 412, 147 Destination: External Annotation: Subtype: Link Rect: 415, 136, 458, 147 Destination: External Annotation: Subtype: Link Rect: 461, 136, 481, 147 Destination: External Annotation: Subtype: Link Rect: 333, 67, 384, 78 Destination: External Annotation: Subtype: Link Rect: 387, 67, 407, 78 Destination: External Annotation: Subtype: Link Rect: 43, 29, 183, 37 Annotation: Subtype: Link Rect: 186, 29, 246, 37 Annotation: Subtype: Link Rect: 423, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 86, 708, 160, 720 Destination: External Annotation: Subtype: Link Rect: 164, 708, 184, 720 Destination: External Annotation: Subtype: Link Rect: 187, 708, 219, 720 Destination: External 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Destination: External Annotation: Subtype: Link Rect: 173, 492, 193, 503 Destination: External Annotation: Subtype: Link Rect: 275, 435, 86, 435 Destination: External Annotation: Subtype: Link Rect: 90, 424, 110, 435 Destination: External Annotation: Subtype: Link Rect: 231, 355, 63, 355 Destination: External Annotation: Subtype: Link Rect: 65, 344, 86, 355 Destination: External Annotation: Subtype: Link Rect: 88, 344, 149, 355 Destination: External Annotation: Subtype: Link Rect: 151, 344, 172, 355 Destination: External Annotation: Subtype: Link Rect: 206, 252, 238, 263 Destination: External Annotation: Subtype: Link Rect: 243, 252, 263, 263 Destination: External Annotation: Subtype: Link Rect: 196, 229, 289, 241 Destination: External Annotation: Subtype: Link Rect: 43, 218, 64, 229 Destination: External Annotation: Subtype: Link Rect: 552, 77, 303, 102 Annotation: Subtype: Link Rect: 43, 29, 183, 37 Annotation: Subtype: Link Rect: 186, 29, 246, 37 Annotation: Subtype: Link Rect: 423, 29, 551, 38 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 102, 659, 160, 668 Annotation: Subtype: Link Rect: 182, 632, 243, 640 Annotation: Subtype: Link Rect: 66, 593, 166, 602 Annotation: Subtype: Link Rect: 185, 574, 248, 583 Annotation: Subtype: Link Rect: 66, 528, 162, 536 Annotation: Subtype: Link Rect: 292, 489, 52, 508 Annotation: Subtype: Link Rect: 170, 471, 238, 479 Annotation: Subtype: Link Rect: 174, 452, 232, 460 Annotation: Subtype: Link Rect: 113, 434, 191, 441 Annotation: Subtype: Link Rect: 153, 405, 238, 413 Annotation: Subtype: Link Rect: 66, 377, 152, 384 Annotation: Subtype: Link Rect: 66, 348, 152, 356 Annotation: Subtype: Link Rect: 207, 329, 291, 337 Annotation: Subtype: Link Rect: 66, 292, 143, 299 Annotation: Subtype: Link Rect: 66, 252, 148, 261 Annotation: Subtype: Link Rect: 167, 235, 242, 242 Annotation: Subtype: Link Rect: 66, 197, 145, 205 Annotation: Subtype: Link Rect: 218, 169, 287, 176 Annotation: Subtype: Link Rect: 66, 129, 148, 138 Annotation: Subtype: Link Rect: 66, 91, 172, 101 Annotation: Subtype: Link Rect: 363, 699, 441, 706 Annotation: Subtype: Link Rect: 327, 660, 413, 668 Annotation: Subtype: Link Rect: 356, 623, 449, 630 Annotation: Subtype: Link Rect: 327, 583, 426, 593 Annotation: Subtype: Link Rect: 407, 564, 537, 574 Annotation: Subtype: Link Rect: 327, 538, 443, 545 Annotation: Subtype: Link Rect: 369, 490, 427, 498 Annotation: Subtype: Link Rect: 327, 452, 409, 460 Annotation: Subtype: Link Rect: 399, 422, 499, 432 Annotation: Subtype: Link Rect: 327, 386, 409, 394 Annotation: Subtype: Link Rect: 327, 358, 404, 366 Annotation: Subtype: Link Rect: 411, 329, 461, 337 Annotation: Subtype: Link Rect: 444, 311, 542, 318 Annotation: Subtype: Link Rect: 341, 271, 399, 280 Annotation: Subtype: Link Rect: 327, 235, 406, 243 Annotation: Subtype: Link Rect: 371, 206, 454, 214 Annotation: Subtype: Link Rect: 460, 178, 527, 185 Annotation: Subtype: Link Rect: 327, 150, 384, 157 Annotation: Subtype: Link Rect: 356, 93, 441, 100 Annotation: Subtype: Link Rect: 43, 28, 183, 36 Annotation: Subtype: Link Rect: 186, 28, 246, 36 Annotation: Subtype: Link Rect: 423, 28, 551, 37 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 292, 698, 52, 716 Annotation: Subtype: Link Rect: 66, 659, 161, 668 Annotation: Subtype: Link Rect: 66, 632, 145, 640 Annotation: Subtype: Link Rect: 66, 594, 165, 602 Annotation: Subtype: Link Rect: 66, 556, 289, 564 Annotation: Subtype: Link Rect: 167, 536, 225, 545 Annotation: Subtype: Link Rect: 119, 509, 187, 517 Annotation: Subtype: Link Rect: 167, 481, 258, 488 Annotation: Subtype: Link Rect: 66, 452, 153, 460 Annotation: Subtype: Link Rect: 66, 413, 172, 422 Annotation: Subtype: Link Rect: 66, 377, 153, 384 Annotation: Subtype: Link Rect: 174, 356, 253, 366 Annotation: Subtype: Link Rect: 66, 319, 162, 328 Annotation: Subtype: Link Rect: 66, 262, 152, 271 Annotation: Subtype: Link Rect: 292, 234, 52, 253 Annotation: Subtype: 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