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Introduction Destination: Head2 Item: Title: 2. Methods Destination: Head3 Children: Item: Title: 2.1. Patients Destination: Head4 Item: Title: 2.2. Ethics Destination: Head5 Item: Title: 2.3. Analysis of triplets size in the AR locus Destination: Head6 Item: Title: 2.4. Binary representation of WES data Destination: Head7 Item: Title: 2.5. LASSO logistic regression Destination: Head8 Item: Title: 2.6. Total T measurement Destination: Head9 Item: Title: 2.7. Statistical analysis Destination: Head10 Item: Title: 2.8. Role of funders Destination: Head11 Item: Title: 3. Results Destination: Head12 Children: Item: Title: 3.1. Testing the role of common poly-amino acid repeat polymorphisms in COVID-19 outcome Destination: Head13 Item: Title: 3.2. Validation of polyQ polymorphism by sizing the PolyQ repeat of the AR gene Destination: Head14 Item: Title: 3.3. Validation of polyQ polymorphism in the Spanish Cohort Destination: Head15 Item: Title: 3.4. Males with longer polyQ have receptor resistance Destination: Head16 Item: Title: 3.5. Unbalanced T-AR axis in males with longer polyQ repeats Destination: Head17 Item: Title: 3.6. Inflammatory phenotype in males with longer polyQ repeats Destination: Head18 Item: Title: 4. Discussion Destination: Head19 Item: Title: Declaration of Competing Interest Destination: Head20 Children: Item: Title: Additional information Destination: Head21 Item: Title: Contributors Destination: Head22 Item: Title: Acknowledgements Destination: Head23 Item: Title: Data availability and data sharing statement Destination: Head24 Item: Title: Supplementary materials Destination: Head25 Children: Item: Title: References Destination: Head26 Info: Title: Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males Author: Margherita Baldassarri Subject: EBioMedicine, 65 (2021) 103246. doi:10.1016/j.ebiom.2021.103246 Keywords: "Androgen receptor gene"; "Testosterone"; "COVID-19"; "LASSO logistic regression"; "WES"; "Viral infection and host genome" Creator: Elsevier Producer: Acrobat Distiller 10.1.10 (Windows) CreationDate: Fri Feb 26 08:17:31 CET 2021 ModDate: Fri Feb 26 08:17:59 CET 2021 ID: 0xa839e897897a846d23cba72db90c3636, 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true EncodingDictionary: Differences: true ToUnicode: true XMP: 2021-02-26T12:17:31+05:30 Elsevier 2021-02-26T12:17:59+05:30 2021-02-26T12:17:59+05:30 Acrobat Distiller 10.1.10 (Windows) Androgen receptor gene,Testosterone,COVID-19,LASSO logistic regression,WES,Viral infection and host genome application/pdf doi:10.1016/j.ebiom.2021.103246 Elsevier B.V. EBioMedicine, 65 (2021) 103246. doi:10.1016/j.ebiom.2021.103246 Androgen receptor gene Testosterone COVID-19 LASSO logistic regression WES Viral infection and host genome Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males Margherita Baldassarri Nicola Picchiotti Francesca Fava Chiara Fallerini Elisa Benetti Sergio Daga Floriana Valentino Gabriella Doddato Simone Furini Annarita Giliberti Rossella Tita Sara Amitrano Mirella Bruttini Susanna Croci Ilaria Meloni Anna Maria Pinto Nicola Iuso Chiara Gabbi Francesca Sciarra Mary Anna Venneri Marco Gori Maurizio Sanarico Francis P. Crawley Uberto Pagotto Flaminia Fanelli Marco Mezzullo Elena Dominguez-Garrido Laura Planas-Serra Agatha Schlüter Roger Colobran Pere Soler-Palacin Pablo Lapunzina Jair Tenorio Aurora Pujol Maria Grazia Castagna Marco Marcelli Andrea M. Isidori Alessandra Renieri Elisa Frullanti Francesca Mari Spanish Covid HGE, GEN-COVID Multicenter Study uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:52e6ef3e-7d09-4795-8a4d-9a6575e7c0c5 journal © 2021 The Author(s). Published by Elsevier B.V. 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