4cfed94f167962a95708adcfe39c1174 pmc_33652812.pdf 578a04d4ddb17c2ebd7cc9a4ce90bec0d8c6f09a pmc_33652812.pdf f992b36cf96e2b68370b7c645a81e129fddd457530a41f5de3091d57b41477fd pmc_33652812.pdf Title: Sarcopenia, Malnutrition, and Cachexia: Adapting Definitions and Terminology of Nutritional Disorders in Older People with Cancer Subject: The recent publication of the revised Consensus on definition and diagnosis of sarcopenia (EWGSOP2) and the Global Leadership Initiative on Malnutrition (GLIM) criteria changed the approach to research on sarcopenia and malnutrition. Whilst sarcopenia is a nutrition-related disease, malnutrition and cachexia are nutritional disorders sharing the common feature of low fat-free mass. However, they have differential characteristics and etiologies, as well as specific therapeutic approaches. Applying the current definitions in clinical practice is still a challenge for health professionals and the potential for misdiagnosis is high. This is of special concern in the subgroup of older people with cancer, in which sarcopenia, malnutrition, and cancer cachexia are highly prevalent and can overlap or occur separately. The purpose of this review is to provide an updated overview of the latest research and consensus definitions of sarcopenia, malnutrition, and cachexia and to discuss their implications for clinical practice in older patients with cancer. The overall aim is to improve the quality of nutritional care in light of the latest findings. Keywords: sarcopenia; malnutrition; cachexia; cancer; muscle mass; older people. Author: Delky Meza-Valderrama, Ester Marco, Vanesa Dávalos-Yerovi, Maria Dolors Muns, Marta Tejero-Sánchez, Esther Duarte and Dolores Sánchez-Rodríguez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Mar 11 09:27:14 2021 CET ModDate: Thu Mar 11 09:30:03 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1073424 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UJMCDG+VnURWPalladioL Type 1 Custom yes yes no 10 0 OKVGYG+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 XCRPPK+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 FGYDGG+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 58 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 62 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 66 0 AAMJJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 88 0 AAMJJI+PalatinoLinotype TrueType WinAnsi yes yes no 91 0 AAMJKK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 94 0 AAMKOD+Calibri,Bold CID TrueType Identity-H yes yes yes 97 0 AAMKOE+Calibri CID TrueType Identity-H yes yes yes 103 0 AAMJJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 126 0 AAMJJI+PalatinoLinotype TrueType WinAnsi yes yes no 129 0 AAMJKK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 132 0 AAMKOD+Calibri,Bold CID TrueType Identity-H yes yes yes 135 0 AAMKOE+Calibri CID TrueType Identity-H yes yes yes 141 0 AAMJJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 159 0 AAMJJI+PalatinoLinotype TrueType WinAnsi yes yes no 162 0 AAMJKK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 165 0 AAMKOD+Calibri,Bold CID TrueType Identity-H yes yes yes 168 0 AAMKOE+Calibri CID TrueType Identity-H yes yes yes 174 0 AAMLPP+Calibri,Italic CID TrueType Identity-H yes yes yes 180 0 AAMJJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 196 0 AAMJJI+PalatinoLinotype TrueType WinAnsi yes yes no 199 0 AAMJKK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 202 0 AAMKOD+Calibri,Bold CID TrueType Identity-H yes yes yes 205 0 AAMKOE+Calibri CID TrueType Identity-H yes yes yes 211 0 SYVAVM+VnURWPalladioL-Italic Type 1 Custom yes yes no 223 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:29:11 CEST RepresentationInformation: pmc_33652812.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:02 CEST Size: 1073424 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 459 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Sarcopenia Destination: section.2 Item: Title: Malnutrition Destination: section.3 Item: Title: Cancer Cachexia Destination: section.4 Item: Title: Overlap and Differential Diagnosis: Upcoming Landmarks and Points for Further Discussion Destination: section.5 Item: Title: Summary Destination: section.6 Item: Title: References Destination: section.6 Info: Title: Sarcopenia, Malnutrition, and Cachexia: Adapting Definitions and Terminology of Nutritional Disorders in Older People with Cancer Author: Delky Meza-Valderrama, Ester Marco, Vanesa Dávalos-Yerovi, Maria Dolors Muns, Marta Tejero-Sánchez, Esther Duarte and Dolores Sánchez-Rodríguez Subject: The recent publication of the revised Consensus on definition and diagnosis of sarcopenia (EWGSOP2) and the Global Leadership Initiative on Malnutrition (GLIM) criteria changed the approach to research on sarcopenia and malnutrition. Whilst sarcopenia is a nutrition-related disease, malnutrition and cachexia are nutritional disorders sharing the common feature of low fat-free mass. However, they have differential characteristics and etiologies, as well as specific therapeutic approaches. Applying the current definitions in clinical practice is still a challenge for health professionals and the potential for misdiagnosis is high. This is of special concern in the subgroup of older people with cancer, in which sarcopenia, malnutrition, and cancer cachexia are highly prevalent and can overlap or occur separately. The purpose of this review is to provide an updated overview of the latest research and consensus definitions of sarcopenia, malnutrition, and cachexia and to discuss their implications for clinical practice in older patients with cancer. The overall aim is to improve the quality of nutritional care in light of the latest findings. Keywords: sarcopenia; malnutrition; cachexia; cancer; muscle mass; older people. 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