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Title:           CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model
Subject:         Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D)
Keywords:        apoptosis, beta cell, CDK11, cyclin D3, inflammation, type 1 diabetes, glucose, insulin
Author:          Ester Sala
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     Item: 
      Title: CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model
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      Children: 
       Item: 
        Title: Introduction
        Destination: s1
       Item: 
        Title: Materials and Methods
        Destination: s2
        Children: 
         Item: 
          Title: Mice
          Destination: s2_1
         Item: 
          Title: Quantitative Real-Time PCR (qRT-PCR)
          Destination: s2_2
         Item: 
          Title: Assessment of Pancreatic Infiltration
          Destination: s2_3
         Item: 
          Title: Diabetes Assessment, Adoptive Transfer Experiments, and Pancreatic Islet Isolation
          Destination: s2_4
         Item: 
          Title: Magnetic Cell Separation of Pancreatic Endocrine Cells (PECs: CD45- Fraction)
          Destination: s2_5
         Item: 
          Title: Western Blot Assays
          Destination: s2_6
         Item: 
          Title: Islet Cell Staining
          Destination: s2_7
         Item: 
          Title: TUNEL Assays
          Destination: s2_8
         Item: 
          Title: Isolation of Islet-Infiltrating Lymphocytes (IILS)
          Destination: s2_9
         Item: 
          Title: Assessment of Immune Cell Subsets by Flow Cytometry
          Destination: s2_10
         Item: 
          Title: DNA Fragmentation Assays
          Destination: s2_11
         Item: 
          Title: ER-Stress Induction
          Destination: s2_12
         Item: 
          Title: Statistical Analysis
          Destination: s2_13
       Item: 
        Title: Results
        Destination: s3
        Children: 
         Item: 
          Title: Cdk11 Is Downregulated in β Cells by Autoimmune Insulitis in a Dose-Dependent Manner Without Impairing β Cell Proliferation
          Destination: s3_1
         Item: 
          Title: CDK11 Hemideficiency Protects N-HTZ Mice Against Diabetes Without Affecting the Diabetogenicity of the Autoimmune Repertoire
          Destination: s3_2
         Item: 
          Title: CDK11 Promotes Cytokine-Induced Beta Cell Apoptosis
          Destination: s3_3
         Item: 
          Title: CDK11 Is Involved in the Upregulation of Atf4 and Chop in Beta Cell Response to ER-Stress, Although ER-Stress Induced Apoptosis Is Not Altered by CDK11 Hemideficiency
          Destination: s3_4
         Item: 
          Title: Cyclin D3 Promotes the Viability of Beta Cells Independently of CDK11 Signaling
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       Item: 
        Title: Discussion
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        Children: 
         Item: 
          Title: Role of CDK11 in the Beta Cell Compartment
          Destination: s4_1
         Item: 
          Title: Role of CDK11 in the Autoimmune Repertoire
          Destination: s4_2
       Item: 
        Title: Conclusion
        Destination: s5
       Item: 
        Title: Data Availability Statement
        Destination: s6
       Item: 
        Title: Ethics Statement
        Destination: s7
       Item: 
        Title: Author Contributions
        Destination: s8
       Item: 
        Title: Funding
        Destination: s9
       Item: 
        Title: Acknowledgments
        Destination: bmark_-366698314
       Item: 
        Title: Supplementary Material
        Destination: bmark_386646472
       Item: 
        Title: References
        Destination: bmark_2090415954
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    Title: CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model
    Author: Ester Sala
    Subject: Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D)
    Keywords: apoptosis, beta cell, CDK11, cyclin D3, inflammation, type 1 diabetes, glucose, insulin
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               <rdf:li>Ester Sala</rdf:li>
               <rdf:li>Celia Vived</rdf:li>
               <rdf:li>J&amp;uacute</rdf:li>
               <rdf:li>lia Luna</rdf:li>
               <rdf:li>Noem&amp;iacute</rdf:li>
               <rdf:li>Alejandra Saavedra-&amp;Aacute</rdf:li>
               <rdf:li>vila</rdf:li>
               <rdf:li>Upasana Sengupta</rdf:li>
               <rdf:li>A. Ra&amp;uacute</rdf:li>
               <rdf:li>l Castaño</rdf:li>
               <rdf:li>Sabrina Villar-Pazos</rdf:li>
               <rdf:li>Laura Haba</rdf:li>
               <rdf:li>Joan Verdaguer</rdf:li>
               <rdf:li>Ana B. Ropero</rdf:li>
               <rdf:li>Thomas Stratmann</rdf:li>
               <rdf:li>Javier Pizarro</rdf:li>
               <rdf:li>Manuel Vázquez-Carrera</rdf:li>
               <rdf:li>Angel Nadal</rdf:li>
               <rdf:li>Jill M. Lahti</rdf:li>
               <rdf:li>Conchi Mora</rdf:li>
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               <rdf:li>cyclin D3</rdf:li>
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               <rdf:li>type 1 diabetes</rdf:li>
               <rdf:li>glucose</rdf:li>
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