d28022e1e12c7d37b3796d2ec34d2aae pmc_33672114.pdf 760c0da053b232e4ef6f678c28fc6343a5e36dda pmc_33672114.pdf 922e5fe4c11c5f5167fc30456cfeac50ac1b94942b5e747c1c5fed1f0163a9fd pmc_33672114.pdf Title: Evolution of Angiogenic Factors in Pregnant Patients with Breast Cancer Treated with Chemotherapy Subject: High prevalence of placental-derived complications, such as preeclampsia and intrauterine growth restriction, has been reported in women with breast cancer (BC) treated with chemotherapy during pregnancy (PBC-CHT). Aim: To ascertain whether PBC-CHT is associated with an imbalance of angiogenic factors, surrogate markers for placental insufficiency, that could explain perinatal outcomes. Methods: Prospective study between 2012 and 2016 in a single institution. Soluble fms-like tyrosine kinase (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng) in maternal blood were assessed throughout pregnancy in 12 women with BC and 215 controls. Results: Cancer patients were treated with doxorubicin-based regimes and with taxanes. Ten PBC-CHT (83%) developed obstetrical complications. At the end of the third trimester, significantly higher levels of sFlt-1; sFlt-1/PGF ratio, and sEng levels were observed in BC women as compared to controls. Moreover; there was a significant correlation between plasma levels of sFlt-1 and the number of chemotherapy cycles administered. Besides, more chemotherapy cycles correlated with lower birthweight and head circumference at birth. Conclusions: Women with BC treated during pregnancy showed an antiangiogenic state compatible with placental insufficiency. Angiogenic factors could be useful in the clinical obstetric management of these patients; although further studies will be required to guide clinical decision-making. Keywords: breast cancer; pregnancy; angiogenic factors; chemotherapy Author: Cristina Saura, Olga Sánchez, Sandra Martínez, Carmen Domínguez, Rodrigo Dienstmann, Fiorella Ruíz-Pace, Maria Concepció Céspedes, Ángeles Peñuelas, Javier Cortés, Elisa Llurba and Octavi Córdoba Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Feb 23 10:16:30 2021 CET ModDate: Tue Feb 23 10:21:49 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1306841 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LXWRNS+VnURWPalladioL Type 1 Custom yes yes no 10 0 RAOPDW+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 TNAURG+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 RDKTWX+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 FFAYKL+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 37 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 59 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 63 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 67 0 QMDDXF+CMSY10 Type 1 Builtin yes yes no 79 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 89 0 AEHELG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 103 0 AEHEMI+PalatinoLinotype TrueType WinAnsi yes yes no 106 0 AEHENK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 109 0 AEHELG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 131 0 AEHEMI+PalatinoLinotype TrueType WinAnsi yes yes no 134 0 AEHENK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 137 0 AEHELG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 159 0 AEHEMI+PalatinoLinotype TrueType WinAnsi yes yes no 162 0 AEHENK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 165 0 AEHELG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 186 0 AEHEMI+PalatinoLinotype TrueType WinAnsi yes yes no 189 0 AEHENK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 192 0 AEHHBO+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 195 0 AEHELG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 210 0 AEHEMH+PalatinoLinotype CID TrueType Identity-H yes yes yes 213 0 AEHEMI+PalatinoLinotype TrueType WinAnsi yes yes no 219 0 AEHENK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 222 0 AEHHBO+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 225 0 AEHELG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 269 0 AEHEMI+PalatinoLinotype TrueType WinAnsi yes yes no 272 0 AEHENK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 275 0 AEHHBO+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 278 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:28:32 CEST RepresentationInformation: pmc_33672114.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:05 CEST Size: 1306841 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 424 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Patients and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Study Procedures Destination: subsection.2.2 Item: Title: Samples Destination: subsection.2.3 Item: Title: Plasma Levels of Angiogenic and Anti-Angiogenic Factors Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Patient Characteristics Destination: subsection.3.1 Item: Title: Chemothepary Treatment Destination: subsection.3.2 Item: Title: Angiogenic Factors Levels in Cases and Control Women Destination: subsection.3.3 Item: Title: Perinatal Outcomes Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Evolution of Angiogenic Factors in Pregnant Patients with Breast Cancer Treated with Chemotherapy Author: Cristina Saura, Olga Sánchez, Sandra Martínez, Carmen Domínguez, Rodrigo Dienstmann, Fiorella Ruíz-Pace, Maria Concepció Céspedes, Ángeles Peñuelas, Javier Cortés, Elisa Llurba and Octavi Córdoba Subject: High prevalence of placental-derived complications, such as preeclampsia and intrauterine growth restriction, has been reported in women with breast cancer (BC) treated with chemotherapy during pregnancy (PBC-CHT). Aim: To ascertain whether PBC-CHT is associated with an imbalance of angiogenic factors, surrogate markers for placental insufficiency, that could explain perinatal outcomes. Methods: Prospective study between 2012 and 2016 in a single institution. Soluble fms-like tyrosine kinase (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng) in maternal blood were assessed throughout pregnancy in 12 women with BC and 215 controls. Results: Cancer patients were treated with doxorubicin-based regimes and with taxanes. Ten PBC-CHT (83%) developed obstetrical complications. At the end of the third trimester, significantly higher levels of sFlt-1; sFlt-1/PGF ratio, and sEng levels were observed in BC women as compared to controls. Moreover; there was a significant correlation between plasma levels of sFlt-1 and the number of chemotherapy cycles administered. Besides, more chemotherapy cycles correlated with lower birthweight and head circumference at birth. Conclusions: Women with BC treated during pregnancy showed an antiangiogenic state compatible with placental insufficiency. Angiogenic factors could be useful in the clinical obstetric management of these patients; although further studies will be required to guide clinical decision-making. 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