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FIDJJH+AdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 101 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:28:06 CEST RepresentationInformation: pmc_33676426.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:07 CEST Size: 717334 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 346 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: sectionAbs1 Children: Item: Title: Background Destination: sectionASec1 Item: Title: Methods Destination: sectionASec2 Item: Title: Results Destination: sectionASec3 Item: Title: Conclusion Destination: sectionASec4 Item: Title: Trial registration Destination: sectionASec5 Item: Title: Background Destination: sectionSec1 Item: Title: Methods Destination: sectionSec2 Children: Item: Title: Study population Destination: sectionSec3 Item: Title: Assessment Destination: sectionSec4 Item: Title: Independent ethics committee (IEC) or institutional review board (IRB) Destination: sectionSec5 Item: Title: Data quality assurance Destination: sectionSec6 Item: Title: Statistical analysis Destination: sectionSec7 Item: Title: Protocol deviations Destination: sectionSec8 Item: Title: Results Destination: sectionSec9 Children: Item: Title: Patient characteristics Destination: sectionSec10 Item: Title: Efficacy results Destination: sectionSec11 Item: Title: Adverse events (AEs) Destination: sectionSec12 Item: Title: Follow up and survival Destination: sectionSec13 Item: Title: Follow up of patients with CNS metastases at osimertinib treatment initiation Destination: sectionSec14 Item: Title: Follow up of patients that received osimertinib as last treatment Destination: sectionSec15 Item: Title: Follow up of T790M+ “de novo” patients Destination: sectionSec16 Item: Title: Health service resources Destination: sectionSec17 Item: Title: Discussion Destination: sectionSec18 Item: Title: Conclusion Destination: sectionSec19 Item: Title: Abbreviations Destination: sectionabr1 Item: Title: Acknowledgements Destination: section1 Item: Title: Authors´ contributions Destination: sectionFPar1 Item: Title: Funding Destination: section2 Item: Title: Availability of data and materials Destination: section3 Item: Title: Ethics approval and consent to participate Destination: sectionFPar2 Item: Title: Consent for publication Destination: sectionFPar3 Item: Title: Competing interests Destination: sectionFPar4 Item: Title: Author details Destination: section4 Item: Title: References Destination: sectionBib1 Item: Title: Publisher’s Note Destination: ArtNote1 Info: Title: Osimertinib in advanced EGFR-T790M mutation-positive non-small cell lung cancer patients treated within the Special Use Medication Program in Spain: OSIREX-Spanish Lung Cancer Group Author: Mariano Provencio Subject: BMC Cancer, 2021, doi:10.1186/s12885-021-07922-5 Keywords: 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