71acb129514e097b646e10d000b58a92  pmc_33716502.pdf
778958536576bdb8d03feacb19b71352b1f1e208  pmc_33716502.pdf
bd02df38baef169aba32deb99206b8d2b42ae0d63a619f60236c5886aac0bd06  pmc_33716502.pdf

Title:          IJN_A_289733 1869..1888
Creator:        Arbortext Advanced Print Publisher 11.0.3433/W Unicode
Producer:       PDFlib+PDI 9.0.3p4 (C++/Win32)
CreationDate:   Thu Mar  4 12:45:17 2021 CET
ModDate:        Thu Mar  4 12:47:09 2021 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          20
Encrypted:      no
Page size:      612 x 792 pts (letter)
Page rot:       0
File size:      16626751 bytes
Optimized:      no
PDF version:    1.5


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OIDKYV+GillSansMT-Identity-H         CID TrueType      Identity-H       yes yes yes     41  0
JOVCVG+GillSansMT-Italic-Identity-H  CID TrueType      Identity-H       yes yes yes     54  0
VNPLIV+GillSansMT-Bold-Identity-H    CID TrueType      Identity-H       yes yes yes    221  0
MKPCUN+TimesNewRomanPSMT-Identity-H  CID TrueType      Identity-H       yes yes yes    225  0
FEVEXZ+MuseeBold                     Type 1C           Custom           yes yes yes    277  0
WRHTHL+GillSansStd-Condensed         Type 1C           Custom           yes yes yes    367  0
INJDVV+Musee                         Type 1C           Custom           yes yes yes    382  0
KYKRNW+TimesNewRomanPS-ItalicMT-Identity-H CID TrueType      Identity-H       yes yes yes    606  0
ULCROR+TimesNewRomanPSMT-Identity-H  CID TrueType      Identity-H       yes yes yes    257  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-03-02 02:36:08 CET
 RepresentationInformation: pmc_33716502.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-03-29 03:36:48 CEST
  Size: 16626751
  Format: PDF
  Version: 1.5
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'refcit0030' cannot be found
   Offset: 16612777
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'refcit0031' cannot be found
   Offset: 16612777
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'refcit0034' cannot be found
   Offset: 16612777
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'refcit0035' cannot be found
   Offset: 16612777
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 0
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Introduction
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
     Item: 
      Title: Materials and Methods
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
      Children: 
       Item: 
        Title: T22-AUR Nanoconjugate Production and Characterization
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: DLBCL Cell Lines and Human PBMCs
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: In vitro Nanoconjugate Internalization
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: Cytotoxicity Assays
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: CXCR4 Flow Cytometry
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: Cell Cycle Analysis
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
       Item: 
        Title: Paraffin-Embedded Cell Blocks
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
       Item: 
        Title: DAPI Staining
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
       Item: 
        Title: Annexin/PI Staining
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
       Item: 
        Title: Western Blotting
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
       Item: 
        Title: Animal Maintenance
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
       Item: 
        Title: In vivo Nanoconjugate Biodistribution
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
       Item: 
        Title: In vivo Nanoconjugate Antineoplastic Effect
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
       Item: 
        Title: Immunofluorescence Microscopy
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
       Item: 
        Title: Histopathology
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
       Item: 
        Title: Immunohistochemistry (IHC)
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
       Item: 
        Title: Statistical Analysis
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
     Item: 
      Title: Results
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
      Children: 
       Item: 
        Title: Characterization of Functionalization of T22-AUR Nanoconjugate
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
       Item: 
        Title: Specific T22-AUR Entrance Through the CXCR4 Receptor in DLBCL Cell Lines
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71
       Item: 
        Title: High Tumor Uptake and Internalization of T22-AUR in SC Tumors of CXCR4<sup>+</sup> DLBCL Cells
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3
       Item: 
        Title: Cytotoxic Effect of Untargeted Free MMAE and CXCR4-Targeted T22-AUR Nanoconjugate on the DLBCL Cell Lines
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca
       Item: 
        Title: Mechanism of Action and Cell Death Induction by T22-AUR in CXCR4<sup>+</sup> DLBCL Cells
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207
       Item: 
        Title: In vivo Antineoplastic Effect of the T22-AUR Nanoconjugate in aCXCR4<sup>+</sup> DLBCL Disseminated Mouse Model
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d
       Item: 
        Title: Lymphoma-Burden Reduction by T22-AUR Nanoconjugate in CXCR4<sup>+</sup> DLBCL Infiltrated Organs
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d
       Item: 
        Title: Absence of Histopathological Alterations in Normal Organs of Mice and Lack of invitro Cytotoxicity in Human PBMCs After T22-AUR Treatment
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf
     Item: 
      Title: Discussion
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f
     Item: 
      Title: Conclusions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468
     Item: 
      Title: Data Sharing Statement
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82
     Item: 
      Title: Acknowledgments
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1
     Item: 
      Title: Author Contributions
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765
     Item: 
      Title: Disclosure
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071
     Item: 
      Title: References
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8
   Filters: 
    FilterPipeline: FlateDecode
   Fonts: 
    Type0: 
     Font: 
      BaseFont: MKPCUN+TimesNewRomanPSMT-Identity-H
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ULCROR+TimesNewRomanPSMT-Identity-H
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: JOVCVG+GillSansMT-Italic-Identity-H
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: OIDKYV+GillSansMT-Identity-H
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: VNPLIV+GillSansMT-Bold-Identity-H
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: KYKRNW+TimesNewRomanPS-ItalicMT-Identity-H
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: FEVEXZ+MuseeBold
      FontSubset: true
      FirstChar: 1
      LastChar: 22
      FontDescriptor: 
       FontName: MuseeBold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -213, -380, 1656, 1102
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INJDVV+Musee
      FontSubset: true
      FirstChar: 1
      LastChar: 16
      FontDescriptor: 
       FontName: Musee
       Flags: Nonsymbolic
       FontBBox: -200, -358, 1652, 1122
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WRHTHL+GillSansStd-Condensed
      FontSubset: true
      FirstChar: 1
      LastChar: 49
      FontDescriptor: 
       FontName: GillSansStd-Condensed
       Flags: Nonsymbolic
       FontBBox: -116, -253, 1006, 868
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: OIDKYV+GillSansMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: GillSansMT
       Flags: Nonsymbolic
       FontBBox: -162, -282, 1041, 918
       FontFile2: true
     Font: 
      BaseFont: KYKRNW+TimesNewRomanPS-ItalicMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TimesNewRomanPS-ItalicMT
       Flags: Nonsymbolic, Italic
       FontBBox: -498, -307, 1333, 1023
       FontFile2: true
     Font: 
      BaseFont: VNPLIV+GillSansMT-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: GillSansMT-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -177, -319, 1167, 939
       FontFile2: true
     Font: 
      BaseFont: JOVCVG+GillSansMT-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: GillSansMT-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -201, -280, 1009, 922
       FontFile2: true
     Font: 
      BaseFont: MKPCUN+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
     Font: 
      BaseFont: ULCROR+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 4.4.0">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:InstanceID>uuid:FAEA222C-14D7-C6F5-0E78-7FC478512156</xmpMM:InstanceID>
         <xmpMM:DocumentID>uuid:7C555218-2A7D-A562-C1E1-FC9939A69DCA</xmpMM:DocumentID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2021-03-04T17:15:17+05:30</xmp:CreateDate>
         <xmp:ModifyDate>2021-03-04T17:17:09+05:30</xmp:ModifyDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 11.0.3433/W Unicode</xmp:CreatorTool>
         <xmp:MetadataDate>2021-03-04T17:17:09+05:30</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>PDFlib+PDI 9.0.3p4 (C++/Win32)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:EPSprocessor>PStill version 1.84.36</pdfx:EPSprocessor>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">IJN_A_289733 1869..1888</rdf:li>
            </rdf:Alt>
         </dc:title>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 537, 129, 547
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 133, 537, 138, 547
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 104, 523, 108, 534
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 111, 523, 115, 534
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 182, 523, 186, 534
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 190, 523, 194, 534
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 124, 510, 128, 520
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 130, 510, 134, 520
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 187, 510, 191, 520
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 193, 510, 197, 520
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 143, 496, 147, 507
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 112, 483, 115, 493
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 117, 483, 121, 493
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 108, 465, 119, 475
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 119, 469, 123, 480
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 125, 469, 129, 480
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 194, 469, 198, 480
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 201, 469, 205, 480
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 150, 456, 154, 466
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 155, 456, 159, 466
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 161, 456, 165, 466
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 107, 442, 111, 453
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 112, 442, 116, 453
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 118, 442, 122, 453
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 108, 424, 119, 435
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 119, 429, 123, 439
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 127, 429, 131, 439
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 110, 415, 114, 426
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 118, 415, 121, 426
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 296, 147, 300, 157
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 481, 104, 485, 114
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 487, 104, 491, 114
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 90, 144, 166, 152
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 90, 72, 167, 80
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 39, 101, 45
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 113, 36, 123, 46
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 129, 37, 140, 46
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 146, 36, 156, 47
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 162, 36, 172, 46
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 219, 31, 260, 45
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 496, 735, 558, 747
       Flags: Print
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 89, 648, 93, 658
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 259, 634, 262, 644
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 132, 550, 136, 560
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 137, 550, 141, 560
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 281, 522, 285, 532
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 286, 522, 290, 532
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 128, 494, 135, 504
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 236, 480, 240, 490
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 241, 480, 249, 490
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 199, 368, 207, 378
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 273, 340, 281, 350
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 283, 340, 290, 350
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 209, 242, 217, 252
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 135, 172, 143, 182
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 237, 130, 244, 140
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 109, 88, 116, 98
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 416, 732, 424, 742
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 476, 704, 484, 714
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 422, 648, 430, 658
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 432, 648, 439, 658
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 462, 620, 469, 630
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 346, 728, 390, 738
       Flags: Print
       Destination: 242
      Annotation: 
       Subtype: Link
       Rect: 432, 685, 474, 695
       Flags: Print
       Destination: 242
      Annotation: 
       Subtype: Link
       Rect: 361, 612, 405, 622
       Flags: Print
       Destination: 242
      Annotation: 
       Subtype: Link
       Rect: 308, 496, 349, 507
       Flags: Print
       Destination: 242
      Annotation: 
       Subtype: Link
       Rect: 515, 316, 541, 326
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 304, 301, 316, 311
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 338, 301, 345, 311
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 394, 70, 435, 80
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 202, 216, 245, 226
       Flags: Print
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 249, 100, 290, 110
       Flags: Print
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 345, 310, 387, 320
       Flags: Print
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 308, 70, 349, 80
       Flags: Print
       Destination: 394
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 182, 537, 225, 547
       Flags: Print
       Destination: 451
      Annotation: 
       Subtype: Link
       Rect: 249, 537, 256, 547
       Flags: Print
       Destination: 451
      Annotation: 
       Subtype: Link
       Rect: 422, 597, 468, 607
       Flags: Print
       Destination: 451
      Annotation: 
       Subtype: Link
       Rect: 404, 540, 450, 549
       Flags: Print
       Destination: 451
      Annotation: 
       Subtype: Link
       Rect: 479, 540, 486, 549
       Flags: Print
       Destination: 451
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 194, 672, 236, 682
       Flags: Print
       Destination: 451
      Annotation: 
       Subtype: Link
       Rect: 98, 510, 106, 520
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 199, 407, 242, 417
       Flags: Print
       Destination: 682
      Annotation: 
       Subtype: Link
       Rect: 238, 154, 277, 164
       Flags: Print
       Destination: 682
      Annotation: 
       Subtype: Link
       Rect: 295, 154, 302, 164
       Flags: Print
       Destination: 682
      Annotation: 
       Subtype: Link
       Rect: 486, 686, 526, 696
       Flags: Print
       Destination: 747
      Annotation: 
       Subtype: Link
       Rect: 546, 686, 552, 696
       Flags: Print
       Destination: 747
      Annotation: 
       Subtype: Link
       Rect: 351, 517, 394, 527
       Flags: Print
       Destination: 747
      Annotation: 
       Subtype: Link
       Rect: 457, 377, 496, 387
       Flags: Print
       Destination: 747
      Annotation: 
       Subtype: Link
       Rect: 515, 377, 521, 387
       Flags: Print
       Destination: 747
      Annotation: 
       Subtype: Link
       Rect: 439, 320, 478, 330
       Flags: Print
       Destination: 747
      Annotation: 
       Subtype: Link
       Rect: 425, 70, 470, 80
       Flags: Print
       Destination: 809
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 126, 166, 136
       Flags: Print
       Destination: 809
      Annotation: 
       Subtype: Link
       Rect: 98, 70, 140, 80
       Flags: Print
       Destination: 809
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 182, 714, 225, 724
       Flags: Print
       Destination: 809
      Annotation: 
       Subtype: Link
       Rect: 182, 351, 221, 361
       Flags: Print
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 262, 183, 302, 193
       Flags: Print
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 391, 714, 432, 724
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 532, 616, 558, 626
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 321, 602, 333, 612
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 324, 518, 367, 528
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 369, 228, 376, 238
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 550, 186, 558, 196
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 349, 130, 356, 140
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 121, 277, 128, 287
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 130, 277, 138, 287
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 120, 147, 127, 157
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 129, 147, 137, 157
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 521, 233, 529, 243
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 355, 118, 374, 128
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 645, 290, 655
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 96, 602, 115, 612
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 159, 501, 166, 511
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 168, 501, 176, 511
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 237, 401, 245, 411
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 247, 401, 254, 411
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 213, 203, 220, 213
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 222, 203, 230, 213
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 221, 147, 228, 157
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 489, 718, 497, 729
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 498, 718, 506, 729
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 498, 635, 505, 644
       Flags: Print
       Destination: 469
      Annotation: 
       Subtype: Link
       Rect: 507, 635, 515, 644
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 371, 480, 379, 491
       Flags: Print
       Destination: 898
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
    Page: 
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 532, 307, 542
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 518, 150, 528
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 284, 490, 307, 500
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 476, 300, 486
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 516, 681, 532, 689
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 388, 671, 453, 679
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 641, 350, 649
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 426, 641, 533, 649
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 502, 621, 518, 629
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Rect: 347, 611, 437, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 536, 581, 552, 589
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 412, 571, 498, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 491, 350, 499
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 406, 491, 490, 499
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 463, 461, 479, 469
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 549, 461, 558, 469
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 450, 420, 458
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 409, 421, 425, 428
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 496, 421, 558, 428
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 438, 380, 454, 388
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 527, 380, 558, 388
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 370, 386, 378
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 426, 340, 442, 348
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 515, 340, 558, 348
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 330, 350, 338
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 498, 300, 514, 308
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 347, 290, 420, 298
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 375, 250, 391, 258
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 459, 250, 546, 258
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 220, 350, 228
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 532, 200, 548, 208
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 392, 190, 452, 198
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 516, 160, 532, 168
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 388, 150, 475, 158
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 486, 120, 502, 128
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 347, 110, 448, 118
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 450, 80, 466, 88
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 516, 80, 558, 88
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 334, 70, 386, 78
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 491, 25, 522, 31
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 70, 754, 111, 762
       Flags: Print
    Page: 
     Sequence: 20
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 179, 709, 195, 717
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 263, 709, 290, 717
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 699, 146, 707
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 76, 669, 92, 677
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 168, 669, 256, 677
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 198, 639, 214, 647
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 281, 639, 290, 647
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 629, 147, 637
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 264, 599, 280, 607
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 136, 589, 243, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 182, 569, 198, 577
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 263, 569, 290, 577
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 559, 113, 567
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 268, 539, 284, 547
       Flags: Print
       Destination: 492
      Annotation: 
       Subtype: Link
       Rect: 124, 529, 231, 537
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 135, 509, 151, 517
       Flags: Print
       Destination: 546
      Annotation: 
       Subtype: Link
       Rect: 223, 509, 290, 517
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 499, 89, 507
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 142, 469, 158, 477
       Flags: Print
       Destination: 869
      Annotation: 
       Subtype: Link
       Rect: 239, 469, 290, 477
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 459, 96, 467
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 148, 429, 164, 437
       Flags: Print
       Destination: 869
      Annotation: 
       Subtype: Link
       Rect: 229, 429, 290, 437
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 419, 90, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 252, 399, 268, 407
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 120, 389, 187, 397
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 180, 369, 196, 377
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 165, 349, 181, 357
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 233, 349, 290, 357
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 339, 93, 347
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 170, 299, 186, 307
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 255, 299, 290, 307
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 66, 289, 153, 297
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 481, 709, 497, 717
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 330, 698, 453, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 499, 668, 515, 676
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 359, 658, 450, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 365, 638, 381, 646
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 436, 638, 509, 646
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 317, 608, 333, 616
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 401, 608, 486, 616
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 397, 577, 413, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 400, 547, 416, 555
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 468, 547, 541, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 511, 527, 527, 535
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 395, 517, 478, 525
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 350, 487, 366, 495
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 422, 487, 516, 495
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 317, 456, 333, 464
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 401, 456, 474, 464
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 436, 426, 452, 434
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 498, 426, 541, 434
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 317, 416, 381, 424
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 317, 386, 333, 394
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 399, 386, 473, 394
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 519, 355, 535, 363
       Flags: Print
       Destination: 245
      Annotation: 
       Subtype: Link
       Rect: 367, 345, 431, 353
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 468, 154, 529, 166
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 436, 94, 526, 102
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 304, 86, 358, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 90, 24, 120, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 500, 754, 541, 762
       Flags: Print
  Checksum: c8749b37
   Type: CRC32
  Checksum: 71acb129514e097b646e10d000b58a92
   Type: MD5
  Checksum: 778958536576bdb8d03feacb19b71352b1f1e208
   Type: SHA-1