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5e56c30f7d06951aa3a50ba22e9080ab2f82be80f88c49c12dd21b3ce3af3da0  pmc_33731007.pdf

Title:           Structural and functional analysis of tomato sterol C22 desaturase
Subject:         BMC Plant Biology, 2021, doi:10.1186/s12870-021-02898-7
Keywords:        Tomato,"Sterol metabolism, Stigmasterol",β-Sitosterol,Cytochrome P450,"Sterol C22-desaturase, endoplasmic reticulum"
Author:          Laura Gutiérrez-García
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     Item: 
      Title: Abstract
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      Children: 
       Item: 
        Title: Background
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       Item: 
        Title: Results
        Destination: sectionASec2
       Item: 
        Title: Conclusions
        Destination: sectionASec3
     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Results
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Tomato C22DES localizes in the ER
        Destination: sectionSec3
       Item: 
        Title: 3D-modeling of tomato C22DES
        Destination: sectionSec4
       Item: 
        Title: TMH is sufficient to target and retain tomato C22DES in the ER membrane
        Destination: sectionSec5
       Item: 
        Title: The globular domain of tomato C22DES interacts with the ER in the absence of TMH
        Destination: sectionSec6
       Item: 
        Title: TMH is required for tomato C22DES activity
        Destination: sectionSec7
       Item: 
        Title: The N-terminal region of C22DES from different plant species share features that may be relevant for enzyme activity
        Destination: sectionSec8
       Item: 
        Title: The globular domain of plant C22DES contains cholesterol recognition/interaction amino acid consensus motifs
        Destination: sectionSec9
     Item: 
      Title: Discussion
      Destination: sectionSec10
     Item: 
      Title: Conclusion
      Destination: sectionSec11
     Item: 
      Title: Methods
      Destination: sectionSec12
      Children: 
       Item: 
        Title: Plant material
        Destination: sectionSec13
       Item: 
        Title: Cloning and plasmid constructions
        Destination: sectionSec14
       Item: 
        Title: Agroinfiltration of N. benthamiana leaves
        Destination: sectionSec15
       Item: 
        Title: Confocal microscopy
        Destination: sectionSec16
       Item: 
        Title: Sterol analysis
        Destination: sectionSec17
       Item: 
        Title: Immunoblot analysis
        Destination: sectionSec18
       Item: 
        Title: In silico analysis of protein structure
        Destination: sectionSec19
       Item: 
        Title: Protein sequence analysis
        Destination: sectionSec20
       Item: 
        Title: Abbreviations
        Destination: sectionabr1
     Item: 
      Title: Supplementary Information
      Destination: sectionSec21
     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
      Destination: section4
     Item: 
      Title: Declarations
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     Item: 
      Title: Ethics approval and consent to participate
      Destination: sectionFPar1
     Item: 
      Title: Consent for publication
      Destination: sectionFPar2
     Item: 
      Title: Competing interests
      Destination: sectionFPar3
     Item: 
      Title: Author details
      Destination: section6
     Item: 
      Title: References
      Destination: sectionBib1
     Item: 
      Title: Publisher’s Note
      Destination: ArtNote1
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    Author: Laura Gutiérrez-García
    Subject: BMC Plant Biology, 2021, doi:10.1186/s12870-021-02898-7
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