a5b72034ab18d2792c422aaa979638d3 pmc_33738082.pdf c42942eca28619ad2784dd2d3d50261febe62a23 pmc_33738082.pdf d3a37b3f9f873ca1d3478ad527fba6df2686c318886874e12e5c290eadc555ae pmc_33738082.pdf Title: Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Thu Mar 11 18:00:16 2021 CET ModDate: Thu Mar 11 18:00:48 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1279964 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CKJMOK+MinionPro-Regular Type 1C Custom yes yes yes 405 0 CKJNEJ+MinionPro-Bold Type 1C Custom yes yes yes 410 0 CKJNII+MinionPro-It Type 1C Custom yes yes yes 415 0 CKJOID+STIXTwoText-Italic Type 1C Custom yes yes yes 156 0 CKKAOE+STIXTwoMath Type 1C Custom yes yes yes 163 0 CKMGAC+STIXTwoText Type 1C WinAnsi yes yes no 132 0 CKMGHA+STIX-Regular Type 1C Custom yes yes yes 138 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:37:09 CEST RepresentationInformation: pmc_33738082.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-03-29 03:36:28 CEST Size: 1279964 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 486 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 1 | INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2 | RESULTS AND DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: 2.1 | Mammalian cell factories produce EVs with high quantities of GLA and SGSH enzymes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.2 | Recombinant EV-GLA restores lysosomal GLA enzymatic activity in GLA defective cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.3 | EVs withstand lyophilization and are safe for intravenous administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.4 | EV-GLA cross the BBB and reduce Gb3 deposits in brain Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 3 | CONCLUSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 4 | EXPERIMENTAL SECTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 5 | ASSOCIATED CONTENT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: CONFLICTS OF INTEREST Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: AUTHOR CONTRIBUTIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: FUNDING SOURCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: SUPPORTING INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Info: Title: Extracellular vesicles from recombinant cell factories improve 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