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Title:           Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration
Subject:         Molecular Therapy: Methods & Clinical Development, 20 (2021) 688-702. doi:10.1016/j.omtm.2021.02.006
Author:          Anna Salas
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      Title: Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration
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       Item: 
        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: Differentiation and characterization of RPE-like cells derived from hiPSCs
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         Item: 
          Title: Differentiation and characterization of RPCs derived from hiPSCs
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         Item: 
          Title: Establishing the optimal RPC developmental time window for transplantation
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         Item: 
          Title: Transplanted RPE + RPCs survive in the subretinal space of RCS rats and can be monitored in vivo over 12 weeks
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         Item: 
          Title: Combined RPE + RPC therapy induces a better survival of endogenous photoreceptors than RPC or RPE cell therapies
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         Item: 
          Title: Combined RPE + RPC therapy preserves visual function better than RPC or RPE cell therapies alone
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         Item: 
          Title: RPC and RPE cells integrate in the degenerating rat retina
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        Title: Discussion
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          Title: Conclusions
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        Title: Materials and methods
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          Title: Cell culture conditions
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         Item: 
          Title: hiPSC differentiation to RPE and RPCs
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          Title: Animals
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          Title: Surgery and transplantation
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          Title: In vivo analyses
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          Title: Histology and immunochemistry
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            Title: RPE flat mounts
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            Title: Histology
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            Title: Immunohistochemistry
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          Title: Statistics
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        Title: Declaration of interests
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  Checksum: f5cd3e56
   Type: CRC32
  Checksum: 3872707597061c221fb8f1652338ca0a
   Type: MD5
  Checksum: 0228146d19185679a46936b6042f839b18b3d3a7
   Type: SHA-1
  Checksum: 03cfcda1900abdb6a843eab20fdd6c34bb1a3b2907d649ca1a2548dd1e197761
   Type: SHA-256