23b7c68a35ad53c32880c17cda307b66 pmc_33746962.pdf 65b682f8f175e64ddd128116aab0d6d51b0f947f pmc_33746962.pdf beb4824e5bf8455754e1efbfd483f996440cfe7b0b3e724a314b3a5089b7c43d pmc_33746962.pdf Title: Diet, Immunity, and Microbiota Interactions: An Integrative Analysis of the Intestine Transcriptional Response and Microbiota Modulation in Gilthead Seabream (Sparus aurata) Fed an Essential Oils-Based Functional Diet Subject: Essential oils (EOs) are promising alternatives to chemotherapeutics in animal production due to their immunostimulant, antimicrobial, and antioxidant properties, without associated environmental or hazardous side effects. Keywords: gut-associated lymphoid tissue, microbiota, additive, functional feed, aquaculture, oral immmunization, teleost, gut immune crosstalk Author: Felipe E. Reyes-López and Enric Gisbert Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Mar 2 07:00:18 2021 CET ModDate: Tue Mar 2 08:57:51 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 7392681 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SLASIQ+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 45 0 OCMSWR+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 50 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 63 0 PBMQKJ+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 65 0 HALEXX+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 71 0 PAMYSM+MinionPro-Regular Type 1C Custom yes yes no 79 0 QBMSYQ+MinionPro-It Type 1C Custom yes yes no 92 0 WGAFBJ+MTSY Type 1C Custom yes yes yes 102 0 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and Microbiota Interactions: An Integrative Analysis of the Intestine Transcriptional Response and Microbiota 䴀漀搀甀氀愀琀椀漀渀 椀渀 䜀椀氀琀栀攀愀搀 匀攀愀戀爀攀愀洀 匀瀀愀爀甀猀 愀甀爀愀琀愀 䘀攀搀 愀渀 䔀猀猀攀渀琀椀愀氀 伀椀氀猀ⴀ䈀愀猀攀搀 䘀甀渀挀琀椀漀渀愀氀 䐀椀攀琩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㌷‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸳㌯䅣瑩潮⽇潔漯偲敶″㘠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Rearing Conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Diets and Feeding Trial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Transcriptional Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: RNA Isolation and Quality Control Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Microarrays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Intestine Functional Analysis: The Search Tool for the Retrieval of Interacting Genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Intestinal Microbiota Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: DNA Extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Amplicon Sequencing of 16S Ribosomal RNA and Sequence Data Processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Microbial Functional Analysis: PICRUSt Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Growth Performance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Microarrays and Gut Transcripteractome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Intestine Microbiota Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: Effect of Garlic, Carvacrol, and Thymol EOs Additive on Proteolysis, Protein Deubiquitination, and Inflammatory Regulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Effect of Garlic, Carvacrol, and Thymol EOs Additive on Immune Effector Processes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Effect of Garlic, Carvacrol, and Thymol EOs Additive on Immune-Related Transport and Secretion Processes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Effect of Garlic, Carvacrol, and Thymol EOs Additive on the Response to Lipids and Hormones Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Effect of Garlic, Carvacrol, and Thymol EOs Additive on the Response to Organic Nitrogen and Aromatic Compounds Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Effect of Garlic, Carvacrol, and Thymol EOs Additive on Symbiosis Processes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Effect of Garlic, Carvacrol, and Thymol EOs Additive on Gene Expression and RNA Processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Info: Title: Diet, Immunity, and Microbiota Interactions: An Integrative Analysis of the Intestine Transcriptional Response and Microbiota Modulation in Gilthead Seabream (Sparus aurata) Fed an Essential Oils-Based Functional Diet Author: Felipe E. Reyes-López and Enric Gisbert Subject: Essential oils (EOs) are promising alternatives to chemotherapeutics in animal production due to their immunostimulant, antimicrobial, and antioxidant properties, without associated environmental or hazardous side effects. 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Felipe E. Reyes-López and Enric Gisbert Diet, Immunity, and Microbiota Interactions: An Integrative Analysis of the Intestine Transcriptional Response and Microbiota Modulation in Gilthead Seabream (Sparus aurata) Fed an Essential Oils-Based Functional Diet gut-associated lymphoid tissue microbiota additive functional feed aquaculture oral immmunization teleost gut immune crosstalk gut-associated lymphoid tissue, microbiota, additive, functional feed, aquaculture, oral immmunization, teleost, gut immune crosstalk dvips + MiKTeX GPL Ghostscript 9.0 uuid:fe2a9d9b-ea19-426a-94e0-ce61f8b9caa4 uuid:428c6557-3298-4a4a-9353-218aa848be55 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 161, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 470, 728, 513, 736 Annotation: Subtype: Link Rect: 513, 729, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 447, 720, 551, 728 Annotation: Subtype: Link Rect: 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Annotation: Subtype: Link Rect: 95, 433, 106, 445 Destination: External Annotation: Subtype: Link Rect: 129, 319, 140, 330 Destination: External Annotation: Subtype: Link Rect: 114, 273, 125, 284 Destination: External Annotation: Subtype: Link Rect: 69, 204, 80, 216 Destination: External Annotation: Subtype: Link Rect: 188, 204, 199, 216 Destination: External Annotation: Subtype: Link Rect: 47, 158, 58, 170 Destination: External Annotation: Subtype: Link Rect: 120, 135, 131, 147 Destination: External Annotation: Subtype: Link Rect: 240, 78, 251, 90 Destination: External Annotation: Subtype: Link Rect: 468, 685, 479, 697 Destination: External Annotation: Subtype: Link Rect: 307, 674, 318, 685 Destination: External Annotation: Subtype: Link Rect: 391, 651, 402, 662 Destination: External Annotation: Subtype: Link Rect: 384, 628, 395, 640 Destination: External Annotation: Subtype: Link Rect: 463, 582, 474, 594 Destination: External Annotation: Subtype: Link Rect: 337, 468, 348, 479 Destination: External Annotation: Subtype: Link Rect: 377, 433, 388, 445 Destination: External Annotation: Subtype: Link Rect: 504, 365, 516, 376 Destination: External Annotation: Subtype: Link Rect: 351, 330, 362, 342 Destination: External Annotation: Subtype: Link Rect: 412, 296, 423, 307 Destination: External Annotation: Subtype: Link Rect: 438, 193, 449, 204 Destination: External Annotation: Subtype: Link Rect: 307, 181, 318, 193 Destination: External Annotation: Subtype: Link Rect: 484, 147, 495, 158 Destination: External Annotation: Subtype: Link Rect: 393, 90, 404, 101 Destination: External Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 169, 559, 180, 571 Destination: External Annotation: Subtype: Link Rect: 82, 525, 93, 536 Destination: External Annotation: Subtype: Link Rect: 98, 525, 109, 536 Destination: External Annotation: Subtype: Link Rect: 248, 502, 259, 514 Destination: External Annotation: Subtype: Link Rect: 220, 239, 231, 250 Destination: External Annotation: Subtype: Link Rect: 173, 216, 184, 227 Destination: External Annotation: Subtype: Link Rect: 218, 204, 229, 216 Destination: External Annotation: Subtype: Link Rect: 159, 181, 170, 193 Destination: External Annotation: Subtype: Link Rect: 274, 113, 285, 124 Destination: External Annotation: Subtype: Link Rect: 475, 697, 486, 708 Destination: External Annotation: Subtype: Link Rect: 349, 640, 360, 651 Destination: External Annotation: Subtype: Link Rect: 355, 617, 366, 628 Destination: External Annotation: Subtype: Link Rect: 404, 525, 415, 536 Destination: External Annotation: Subtype: Link Rect: 338, 468, 349, 479 Destination: External Annotation: Subtype: Link Rect: 307, 456, 318, 468 Destination: External Annotation: Subtype: Link Rect: 307, 422, 318, 433 Destination: External Annotation: Subtype: Link Rect: 490, 239, 496, 250 Destination: External Annotation: Subtype: Link Rect: 425, 193, 436, 204 Destination: External Annotation: Subtype: Link Rect: 396, 67, 408, 78 Destination: External Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Label: 15 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 173, 708, 184, 720 Destination: External Annotation: Subtype: Link Rect: 189, 708, 200, 720 Destination: External Annotation: Subtype: Link Rect: 74, 640, 85, 651 Destination: External Annotation: Subtype: Link Rect: 158, 617, 169, 628 Destination: External Annotation: Subtype: Link Rect: 186, 594, 197, 605 Destination: External Annotation: Subtype: Link Rect: 203, 594, 214, 605 Destination: External Annotation: Subtype: Link Rect: 216, 571, 227, 582 Destination: External Annotation: Subtype: Link Rect: 230, 502, 242, 514 Destination: External Annotation: Subtype: Link Rect: 132, 353, 143, 365 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Annotations: Annotation: Subtype: Link Rect: 43, 261, 142, 271 Destination: External Annotation: Subtype: Link Rect: 552, 199, 303, 224 Annotation: Subtype: Link Rect: 552, 118, 316, 138 Annotation: Subtype: Link Rect: 331, 81, 435, 90 Annotation: Subtype: Link Rect: 43, 28, 117, 36 Annotation: Subtype: Link Rect: 120, 28, 180, 36 Annotation: Subtype: Link Rect: 426, 28, 551, 37 Page: Label: 17 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 70, 678, 177, 687 Annotation: Subtype: Link Rect: 129, 640, 228, 649 Annotation: Subtype: Link Rect: 70, 576, 154, 583 Annotation: Subtype: Link Rect: 146, 538, 235, 545 Annotation: Subtype: Link Rect: 70, 508, 128, 517 Annotation: Subtype: Link Rect: 70, 470, 241, 479 Annotation: Subtype: Link Rect: 70, 432, 150, 441 Annotation: Subtype: Link Rect: 122, 396, 207, 403 Annotation: Subtype: Link Rect: 70, 358, 151, 366 Annotation: Subtype: Link Rect: 85, 328, 171, 337 Annotation: Subtype: Link Rect: 70, 301, 154, 309 Annotation: Subtype: Link Rect: 70, 263, 164, 271 Annotation: Subtype: Link Rect: 70, 224, 174, 233 Annotation: Subtype: Link Rect: 70, 176, 169, 186 Annotation: Subtype: Link Rect: 147, 159, 243, 166 Annotation: Subtype: Link Rect: 70, 131, 166, 138 Annotation: Subtype: Link Rect: 81, 102, 166, 110 Annotation: Subtype: Link Rect: 104, 72, 196, 82 Annotation: Subtype: Link Rect: 365, 678, 440, 687 Annotation: Subtype: Link Rect: 331, 642, 417, 649 Annotation: Subtype: Link Rect: 382, 602, 475, 612 Annotation: Subtype: Link Rect: 331, 576, 414, 583 Annotation: Subtype: Link Rect: 448, 538, 532, 545 Annotation: Subtype: Link Rect: 331, 500, 395, 507 Annotation: Subtype: Link Rect: 371, 451, 464, 460 Annotation: Subtype: Link Rect: 427, 404, 520, 413 Annotation: Subtype: Link Rect: 476, 386, 551, 394 Annotation: Subtype: Link Rect: 331, 358, 411, 366 Annotation: Subtype: Link Rect: 331, 320, 448, 328 Annotation: Subtype: Link Rect: 331, 281, 437, 290 Annotation: Subtype: Link Rect: 393, 252, 470, 261 Annotation: Subtype: Link Rect: 393, 224, 497, 233 Annotation: Subtype: Link Rect: 365, 176, 440, 186 Annotation: Subtype: Link Rect: 331, 131, 413, 138 Annotation: Subtype: Link Rect: 420, 110, 482, 119 Annotation: Subtype: Link Rect: 331, 74, 411, 82 Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Label: 18 Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 205, 689, 290, 696 Annotation: Subtype: Link Rect: 173, 651, 262, 659 Annotation: Subtype: Link Rect: 70, 623, 154, 631 Annotation: Subtype: Link Rect: 158, 594, 235, 602 Annotation: Subtype: Link Rect: 70, 555, 172, 564 Annotation: Subtype: Link Rect: 154, 517, 233, 526 Annotation: Subtype: Link Rect: 70, 479, 167, 489 Annotation: Subtype: Link Rect: 70, 441, 148, 451 Annotation: Subtype: Link Rect: 165, 405, 261, 413 Annotation: Subtype: Link Rect: 192, 386, 281, 394 Annotation: Subtype: Link Rect: 129, 356, 205, 365 Annotation: Subtype: Link Rect: 93, 329, 174, 337 Annotation: Subtype: Link Rect: 111, 281, 204, 290 Annotation: Subtype: Link Rect: 170, 243, 274, 252 Annotation: Subtype: Link Rect: 70, 176, 146, 186 Annotation: Subtype: Link Rect: 95, 150, 145, 157 Annotation: Subtype: Link Rect: 101, 121, 182, 129 Annotation: Subtype: Link Rect: 70, 72, 146, 82 Annotation: Subtype: Link Rect: 386, 697, 472, 706 Annotation: Subtype: Link Rect: 386, 680, 450, 687 Annotation: Subtype: Link Rect: 341, 640, 424, 649 Annotation: Subtype: Link Rect: 331, 602, 428, 611 Annotation: Subtype: Link Rect: 375, 566, 449, 574 Annotation: Subtype: Link Rect: 442, 538, 517, 545 Annotation: Subtype: Link Rect: 331, 508, 395, 517 Annotation: Subtype: Link Rect: 399, 460, 479, 470 Annotation: Subtype: Link Rect: 397, 405, 483, 413 Annotation: Subtype: Link Rect: 331, 366, 409, 375 Annotation: Subtype: Link Rect: 413, 328, 489, 337 Annotation: Subtype: Link Rect: 338, 292, 423, 299 Annotation: Subtype: Link Rect: 331, 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220, 365 Annotation: Subtype: Link Rect: 450, 687, 543, 697 Annotation: Subtype: Link Rect: 354, 651, 442, 659 Annotation: Subtype: Link Rect: 331, 622, 431, 631 Annotation: Subtype: Link Rect: 331, 593, 430, 602 Annotation: Subtype: Link Rect: 396, 555, 476, 564 Annotation: Subtype: Link Rect: 341, 527, 419, 536 Annotation: Subtype: Link Rect: 464, 508, 544, 517 Annotation: Subtype: Link Rect: 422, 405, 448, 412 Annotation: Subtype: Link Rect: 448, 405, 480, 412 Annotation: Subtype: Link Rect: 479, 405, 515, 412 Annotation: Subtype: Link Rect: 514, 405, 537, 412 Annotation: Subtype: Link Rect: 552, 393, 303, 413 Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Checksum: 1332ae6e Type: CRC32 Checksum: 23b7c68a35ad53c32880c17cda307b66 Type: MD5 Checksum: 65b682f8f175e64ddd128116aab0d6d51b0f947f Type: SHA-1