b95f867583c865223ebdec50b6ead219 pmc_33772065.pdf b1a324c1925296f4d9061a3bf84ec212de9a9a90 pmc_33772065.pdf 4c7f0e8ca9bc7da53ffd9d4ac9ada310a427b01e2d2b99544deeaf4c4b861ce5 pmc_33772065.pdf Title: Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC) Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-86218-x Author: Jazmine Arévalo Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Mar 22 07:11:21 2021 CET ModDate: Mon Mar 22 10:46:21 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2163444 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VPYANU+Wingdings-Regular Type 1C WinAnsi yes yes yes 289 0 MinionPro-Regular Type 1C Custom yes no yes 47 0 Corbel-BoldItalic TrueType WinAnsi yes no yes 290 0 WPTZKF+Corbel-Bold CID TrueType Identity-H yes yes yes 49 0 Corbel2 TrueType WinAnsi yes no yes 50 0 RPKASP+Corbel CID TrueType Identity-H yes yes yes 51 0 MinionPro-It Type 1C Custom yes no yes 48 0 MinionPro-Bold Type 1C Custom yes no yes 63 0 VXNTVX+MinionPro-BoldIt Type 1C WinAnsi yes yes yes 64 0 VBUYRC+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 150 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:36:07 CEST RepresentationInformation: pmc_33772065.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-04-05 03:36:27 CEST Size: 2163444 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 356 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC) Children: Item: Title: Results Children: Item: Title: Study group. Item: Title: ccRCC tumors exhibit different pS727-STAT3 location patterns between the nucleus and the cytosol. Item: Title: High nuclear and cytosolic pS727-STAT3 levels identify patients with the lowest overall survival among those with advanced-stage ccRCC disease. Item: Title: ccRCC patients with high nuclear expression of pS727-STAT3 exhibit increased disease-free survival after adjuvant treatment. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Case selection. Item: Title: Tissue microarray (TMA). Item: Title: TMA immunohistochemistry. Item: Title: TMA evaluation. Item: Title: Statistical analyses. Item: Title: References Item: Title: Acknowledgements Info: Title: Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC) Author: Jazmine Arévalo Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-86218-x Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Mar 22 07:41:21 CET 2021 ModDate: Mon Mar 22 10:46:21 CET 2021 ID: 0xf16d2b70f65e1821adef083cee341b1b, 0x799eb60979a42c02a42c6bac8b3c7a7c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1789 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2008 ImageHeight: 1503 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: WPTZKF+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: RPKASP+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VXNTVX+MinionPro-BoldIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: VXNTVX+MinionPro-BoldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -230, -360, 1684, 1032 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: VPYANU+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: VPYANU+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: Corbel-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: VBUYRC+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: VBUYRC+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: RPKASP+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RPKASP+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: WPTZKF+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WPTZKF+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2021-03-22T11:41:21+05:30 Springer 2021-03-22T10:46:21+01:00 2021-03-22T10:46:21+01:00 application/pdf https://doi.org/10.1038/s41598-021-86218-x Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-021-86218-x Nuclear and cytosolic pS727-STAT3 levels correlate with overall survival of patients affected by clear cell renal cell carcinoma (ccRCC) Jazmine Arévalo David Lorente Enrique Trilla María Teresa Salcedo Juan Morote Anna Meseguer 10.1038/s41598-021-86218-x 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-021-86218-x 10.1038/s41598-021-86218-x 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-021-86218-x noindex springer.com springerlink.com VoR uuid:1d12ec02-f69a-4bce-bb2c-8e21a16a2e83 uuid:f23f7a15-33e8-4891-93f3-d6dbc845e7f3 default 1 converted uuid:2799741a-3a61-479d-a259-9bc66db4d93e converted to PDF/A-2b pdfToolbox 2021-03-22T11:42:31+05:30 converted uuid:155a7475-4d9e-437c-8854-f6b8f17df968 converted to PDF/A-2b pdfToolbox 2021-03-22T11:43:01+05:30 Adobe PDF Library 15.0; 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