eb2ade9d4884eeb3ea744e7f5e3f72a7 pmc_33796079.pdf 16a67c3f6f1020207a3947487a84484d011da45f pmc_33796079.pdf 90578452b0b21f8f9dc25fd53212899f57536d581cbcb6346cb9488d76022df0 pmc_33796079.pdf Title: Pasireotide in the Personalized Treatment of Acromegaly Subject: The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some Keywords: resistance to medical treatment in acromegaly, somatostatin analogues, somatostatin receptor ligands, personalized medicine, somatotroph adenoma, growth hormone, PitNETs, endocrine tumors Author: Manel Puig-Domingo Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Mar 11 05:58:20 2021 CET ModDate: Fri Mar 12 03:41:49 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no 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Offset: 710543 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B89' cannot be found Offset: 710543 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B90' cannot be found Offset: 710543 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B91' cannot be found Offset: 710543 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 538 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Pasireotide in the Personalized Treatment of Acromegaly Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Current Options of Pharmacologic Treatment of Acromegaly Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Imaging Markers of Response to Pasireotide Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Functional Tests for Prediction of Pasireotide Response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Molecular Markers of Response to Pasireotide Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Info: Title: Pasireotide in the Personalized Treatment of Acromegaly Author: Manel Puig-Domingo Subject: The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some Keywords: resistance to medical treatment in acromegaly, somatostatin analogues, somatostatin receptor ligands, personalized medicine, somatotroph adenoma, growth hormone, PitNETs, endocrine tumors Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Mar 11 05:58:20 CET 2021 ModDate: Thu Mar 11 15:41:49 CET 2021 ID: 0xaa9752598436840a7e8273616b8f963e, 0xeabbf37722f2c9409a7a2ae14ff52787 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1299 ImageHeight: 741 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer 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FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding XMP: Acrobat Distiller 7.0 (Windows) resistance to medical treatment in acromegaly, somatostatin analogues, somatostatin receptor ligands, personalized medicine, somatotroph adenoma, growth hormone, PitNETs, endocrine tumors 2021-03-11T12:58:20+08:00 2021-03-11T14:41:49-12:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2021-03-11T14:41:49-12:00 application/pdf Manel Puig-Domingo Ignacio Bernabéu Antonio Pico Betina Biagetti Joan Gil Cristina Alvarez-Escolá Mireia Jord&agrave Montserrat Marques-Pamies Berta Soldevila Mar&iacute a-Angeles Gálvez Rosa Cámara Javier Aller Cristina Lamas M&oacute nica Marazuela The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some Pasireotide in the Personalized Treatment of 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