7bdfb42d1baf5338b3d47288298967df pmc_33802835.pdf 686f9b439fcbe2c766c1053b4297e484aaf243c9 pmc_33802835.pdf de747a77136314863d451d35bae43945d47cef2bd77d7514b6a5eb05fe1bb1ba pmc_33802835.pdf Title: A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy Subject: (1) Background: among all types of radiation, very heavy ions, such as Neon (Ne) or Argon (Ar), are the optimum candidates for hypoxic tumor treatments due to their reduced oxygen enhancement effect. However, their pioneering clinical use in the 1970s was halted due to severe side effects. The aim of this work was to provide a first proof that the combination of very heavy ions with minibeam radiation therapy leads to a minimization of toxicities and, thus, opening the door for a renewed use of heavy ions for therapy; (2) Methods: mouse legs were irradiated with either Ne MBRT or Ne broad beams at the same average dose. Skin toxicity was scored for a period of four weeks. Histopathology evaluations were carried out at the end of the study; (3) Results: a significant difference in toxicity was observed between the two irradiated groups. While severe da-mage, including necrosis, was observed in the broad beam group, only light to mild erythema was present in the MBRT group; (4) Conclusion: Ne MBRT is significantly better tolerated than conventional broad beam irradiations. Keywords: minibeam radiation therapy; heavy ion therapy; hypoxic tumors; normal tissue toxicity Author: Yolanda Prezado, Ryochi Hirayama, Naruhiro Matsufuji, Taku Inaniwa, Immaculada Martínez-Rovira, Olivier Seksek, Annaïg Bertho, Sachiko Koike, Dalila Labiod, Frederic Pouzoulet, Laura Polledo, Nils Warfving, Aléthéa Liens, Judith Bergs and Takashi Shimokawa Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 19 07:55:14 2021 CET ModDate: Fri Mar 19 09:06:51 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 54588663 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OYGWHX+VnURWPalladioL Type 1 Custom yes yes no 10 0 ADDHHA+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 NLXKFG+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 STNPYT+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 37 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 59 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 63 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 67 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 79 0 NJAOJC+CMSY10 Type 1 Builtin yes yes no 87 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 02:47:32 CEST RepresentationInformation: pmc_33802835.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 12:09:28 CEST Size: 54588663 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 383 FreeObjects: 25 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Irradiations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: In Vivo Experiment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Info: Title: A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy Author: Yolanda Prezado, Ryochi Hirayama, Naruhiro Matsufuji, Taku Inaniwa, Immaculada Martínez-Rovira, Olivier Seksek, Annaïg Bertho, Sachiko Koike, Dalila Labiod, Frederic Pouzoulet, Laura Polledo, Nils Warfving, Aléthéa Liens, Judith Bergs and Takashi Shimokawa Subject: (1) Background: among all types of radiation, very heavy ions, such as Neon (Ne) or Argon (Ar), are the optimum candidates for hypoxic tumor treatments due to their reduced oxygen enhancement effect. However, their pioneering clinical use in the 1970s was halted due to severe side effects. The aim of this work was to provide a first proof that the combination of very heavy ions with minibeam radiation therapy leads to a minimization of toxicities and, thus, opening the door for a renewed use of heavy ions for therapy; (2) Methods: mouse legs were irradiated with either Ne MBRT or Ne broad beams at the same average dose. Skin toxicity was scored for a period of four weeks. Histopathology evaluations were carried out at the end of the study; (3) Results: a significant difference in toxicity was observed between the two irradiated groups. While severe da-mage, including necrosis, was observed in the broad beam group, only light to mild erythema was present in the MBRT group; (4) Conclusion: Ne MBRT is significantly better tolerated than conventional broad beam irradiations. 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