59441e996518b8e16c5605fcaeb83b83 pmc_33803133.pdf 55e240566137a41888101156d7a7eaf6c3ac8b4a pmc_33803133.pdf b0243a31a236c9c4fbd8a1ef741d922232c384a8d422b99afb5031e93db89c1b pmc_33803133.pdf Title: Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field Subject: Cancer remains as the second leading cause of death, worldwide. Despite the enormous important advances observed in the last decades, advanced stages of the disease remain incurable. The severe side effects associated to systemic high doses of chemotherapy and the development of drug resistance impairs a safe and efficiency anticancer therapy. Therefore, new formulations are continuously under research and development to improve anticancer drugs therapeutic index through localized delivery at tumor sites. Among a wide range of possibilities, hydrogels have recently gained special attention due to their potential to allow in situ sustained and controlled anticancer drug release. In particular, stimuli-responsive hydrogels which are able to change their physical state from liquid to gel accordingly to external factors such as temperature, pH, light, ionic strength, and magnetic field, among others. Some of these formulations presented promising results for the localized control and treatment of cancer. The present work aims to discuss the main properties and application of stimuli-responsive hydrogels in cancer treatment and summarize the most important advances observed in the last decades focusing on the use of pH-, light-, ionic strength-, and magnetic-responsive hydrogels. Keywords: hydrogels; pH-responsive; photosensitive; ionic strength-responsive; magnetic-responsive; drug delivery; cancer treatment; local treatment Author: Fernanda Andrade, Maria Mercé Roca-Melendres, Esteban F. Durán-Lara, Diana Rafael and Simó Schwartz Jr. Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Mar 9 09:45:15 2021 CET ModDate: Tue Mar 9 09:49:14 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 5506740 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZZTQUO+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 PSUYZB+VnURWPalladioL Type 1 Custom yes yes no 15 0 NYLLGT+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 WKWTML+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 XAJAVI+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 37 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 59 0 MCBCCM+SourceSansRoman.613wght Type 1C 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1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:28 CEST Size: 5506740 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 920 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Hydrogels for Biomedical Applications Destination: section.2 Item: Title: Classification of Hydrogels Destination: section.3 Item: Title: Stimuli-Responsive Hydrogels Destination: section.4 Children: Item: Title: pH-Sensitive Hydrogels Destination: subsection.4.1 Item: Title: Photosensitive Hydrogels Destination: subsection.4.2 Item: Title: Ionic Strength and Magnetic-Responsive Hydrogels Destination: subsection.4.3 Item: Title: Dual-Responsive Hydrogels Destination: subsection.4.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Stimuli-Responsive Hydrogels for Cancer Treatment: The Role of pH, Light, Ionic Strength and Magnetic Field Author: Fernanda Andrade, Maria Mercé Roca-Melendres, Esteban F. Durán-Lara, Diana Rafael and Simó Schwartz Jr. Subject: Cancer remains as the second leading cause of death, worldwide. Despite the enormous important advances observed in the last decades, advanced stages of the disease remain incurable. The severe side effects associated to systemic high doses of chemotherapy and the development of drug resistance impairs a safe and efficiency anticancer therapy. Therefore, new formulations are continuously under research and development to improve anticancer drugs therapeutic index through localized delivery at tumor sites. Among a wide range of possibilities, hydrogels have recently gained special attention due to their potential to allow in situ sustained and controlled anticancer drug release. In particular, stimuli-responsive hydrogels which are able to change their physical state from liquid to gel accordingly to external factors such as temperature, pH, light, ionic strength, and magnetic field, among others. Some of these formulations presented promising results for the localized control and treatment of cancer. The present work aims to discuss the main properties and application of stimuli-responsive hydrogels in cancer treatment and summarize the most important advances observed in the last decades focusing on the use of pH-, light-, ionic strength-, and magnetic-responsive hydrogels. 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