604c1a3c983794d118643ef99e216a75 pmc_33805974.pdf 7488ec948563c6885e071d6764270fee5f1826de pmc_33805974.pdf 3d09f4cfc32368c2007ea4a6d8e1d810c7d6ff8d95269aa66c3723b1a84bce65 pmc_33805974.pdf Title: SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease Subject: The semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1) or primary amine oxidase (PrAO), is a deaminating enzyme highly expressed in vessels that generates harmful products as a result of its enzymatic activity. As a multifunctional enzyme, it is also involved in inflammation through its ability to bind and promote the transmigration of circulating leukocytes into inflamed tissues. Inflammation is present in different systemic and cerebral diseases, including stroke and Alzheimer’s disease (AD). These pathologies show important affectations on cerebral vessels, together with increased SSAO levels. This review summarizes the main roles of SSAO/VAP-1 in human physiology and pathophysiology and discusses the mechanisms by which it can affect the onset and progression of both stroke and AD. As there is an evident interrelationship between stroke and AD, basically through the vascular system dysfunction, the possibility that SSAO/VAP-1 could be involved in the transition between these two pathologies is suggested. Hence, its inhibition is proposed to be an interesting therapeutical approach to the brain damage induced in these both cerebral pathologies. Keywords: SSAO/VAP-1; stroke; Alzheimer’s disease; vascular damage; blood–brain barrier dysfunction; neurovascular unit; inflammation; oxidative stress Author: Mercedes Unzeta, Mar Hernàndez-Guillamon, Ping Sun and Montse Solé Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 26 03:03:41 2021 CET ModDate: Fri Mar 26 03:23:19 2021 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 30 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1359203 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IYDCBB+VnURWPalladioL Type 1 Custom yes yes no 10 0 UWSHOD+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 LMZYKC+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 EXNFTU+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 FFJOOI+CMSY10 Type 1 Builtin yes yes no 28 0 MWJZGO+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 40 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 43 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 73 0 CHMOKT+EURM10 Type 1 Builtin yes yes no 88 0 ABCDEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 128 0 ABCDEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 132 0 ABCDEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 136 0 ABCDEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 140 0 SymbolMT CID TrueType Identity-H yes no yes 147 0 ArialMT TrueType WinAnsi no no no 156 0 ArialMT CID TrueType Identity-H yes no yes 159 0 ABCDEE+Arial-BoldMT TrueType WinAnsi yes yes no 167 0 FENJOA+Arial,BoldItalic CID TrueType Identity-H yes yes yes 212 0 FENJPA+Arial,BoldItalic TrueType WinAnsi yes yes no 218 0 FENKHO+Calibri,Bold CID TrueType Identity-H yes yes yes 221 0 FENLAM+MicrosoftSansSerif CID TrueType Identity-H yes yes yes 227 0 FEKLPB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 233 0 FEKMAB+PalatinoLinotype CID TrueType Identity-H yes yes yes 236 0 FEKMAC+PalatinoLinotype TrueType WinAnsi yes yes no 242 0 FEKMBE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 245 0 FENDBH+Arial,Bold CID TrueType Identity-H yes yes yes 248 0 FENDEH+Arial CID TrueType Identity-H yes yes yes 254 0 TVGGGO+Dingbats Type 1 Builtin yes yes no 290 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:24:38 CEST RepresentationInformation: pmc_33805974.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:31 CEST Size: 1359203 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1133 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Children: Item: Title: SSAO: An Amine Oxidase Destination: subsection.1.1 Item: Title: SSAO/VAP-1: Expression and Tissular Localization Destination: subsection.1.2 Item: Title: SSAO/VAP-1 Physiological Functions Destination: subsection.1.3 Children: Item: Title: Amine Deamination Destination: subsubsection.1.3.1 Item: Title: Activation of Glucose Transport Destination: subsubsection.1.3.2 Item: Title: Leukocyte Adhesion Function under Inflammation Destination: subsubsection.1.3.3 Item: Title: SSAO/VAP-1 Involvement in Pathological Conditions Destination: subsection.1.4 Item: Title: Cerebrovascular Dysfunction in Stroke and AD Destination: section.2 Children: Item: Title: The BBB and Cerebrovascular Dysfunction Destination: subsection.2.1 Item: Title: Stroke Destination: subsection.2.2 Item: Title: Alzheimer’s Disease and Cerebral Amyloid Angiopathy Destination: subsection.2.3 Item: Title: SSAO/VAP-1 and Cerebrovascular Dysfunction Destination: section.3 Children: Item: Title: SSAO/VAP-1 in Stroke Destination: subsection.3.1 Item: Title: SSAO/VAP-1 in Alzheimer’s Disease Destination: subsection.3.2 Item: Title: Can SSAO/VAP-1 Be a Link between Stroke and AD? Destination: section.4 Children: Item: Title: Stroke and the Risk for AD Destination: subsection.4.1 Item: Title: AD and the Risk for Stroke Destination: subsection.4.2 Item: Title: SSAO/VAP-1 As a Possible Link between Stroke and AD Destination: subsection.4.3 Item: Title: Therapeutic Approach to Stroke and AD by SSAO/VAP-1 Inhibition Destination: section.5 Item: Title: Conclusions Destination: section.6 Item: Title: References Destination: section.6 Info: Title: SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer’s Disease Author: Mercedes Unzeta, Mar Hernàndez-Guillamon, Ping Sun and Montse Solé Subject: The semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1) or primary amine oxidase (PrAO), is a deaminating enzyme highly expressed in vessels that generates harmful products as a result of its enzymatic activity. As a multifunctional enzyme, it is also involved in inflammation through its ability to bind and promote the transmigration of circulating leukocytes into inflamed tissues. Inflammation is present in different systemic and cerebral diseases, including stroke and Alzheimer’s disease (AD). These pathologies show important affectations on cerebral vessels, together with increased SSAO levels. This review summarizes the main roles of SSAO/VAP-1 in human physiology and pathophysiology and discusses the mechanisms by which it can affect the onset and progression of both stroke and AD. As there is an evident interrelationship between stroke and AD, basically through the vascular system dysfunction, the possibility that SSAO/VAP-1 could be involved in the transition between these two pathologies is suggested. Hence, its inhibition is proposed to be an interesting therapeutical approach to the brain damage induced in these both cerebral pathologies. Keywords: SSAO/VAP-1; stroke; Alzheimer’s disease; vascular damage; blood brain barrier dysfunction; neurovascular unit; inflammation; oxidative stress Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 26 03:03:41 CET 2021 ModDate: Fri Mar 26 03:23:19 CET 2021 ID: 0xbbd9f2cdc425065015b2113ea01a6721, 0xbbd9f2cdc425065015b2113ea01a6721 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: MWJZGO+VnURWPalladioL-Bold FontSubset: true FirstChar: 160 LastChar: 178 FontDescriptor: FontName: MWJZGO+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TVGGGO+Dingbats FontSubset: true FirstChar: 73 LastChar: 73 FontDescriptor: FontName: TVGGGO+Dingbats Flags: Symbolic FontBBox: -1, -143, 981, 819 FontFile: true Font: BaseFont: LMZYKC+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: LMZYKC+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EXNFTU+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: EXNFTU+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CHMOKT+EURM10 FontSubset: true FirstChar: 11 LastChar: 34 FontDescriptor: FontName: CHMOKT+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: IYDCBB+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 243 FontDescriptor: FontName: IYDCBB+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FFJOOI+CMSY10 FontSubset: true FirstChar: 1 LastChar: 33 FontDescriptor: FontName: FFJOOI+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: UWSHOD+URWPalladioL-Ital FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: UWSHOD+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 35, 759, 181, 795 Annotation: Subtype: Link Rect: 515, 759, 560, 795 Annotation: Subtype: Link Rect: 316, 659, 328, 673 Annotation: Subtype: Link Rect: 411, 659, 422, 673 Annotation: Subtype: Link Rect: 116, 346, 154, 355 Annotation: Subtype: Link Rect: 35, 334, 130, 343 Annotation: Subtype: Link Rect: 35, 162, 97, 184 Annotation: Subtype: Link Rect: 153, 89, 154, 98 Annotation: Subtype: Link Rect: 35, 77, 147, 86 Annotation: Subtype: Link Rect: 391, 227, 398, 235 ActionDest: 268 Annotation: Subtype: Link Rect: 293, 201, 300, 210 ActionDest: 268 Annotation: Subtype: Link Rect: 301, 201, 308, 210 ActionDest: 268 Annotation: Subtype: Link Rect: 302, 151, 309, 160 ActionDest: 268 Annotation: Subtype: Link Rect: 312, 151, 319, 160 ActionDest: 268 Annotation: Subtype: Link Rect: 436, 68, 443, 76 ActionDest: 268 Annotation: Subtype: Link Rect: 524, 65, 530, 77 ActionDest: 82 Annotation: Subtype: Link Rect: 139, 17, 278, 28 Annotation: Subtype: Link Rect: 420, 17, 558, 28 Annotation: Subtype: Link Rect: 35, 435, 87, 454 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 480, 711, 487, 721 ActionDest: 268 Annotation: Subtype: Link Rect: 490, 711, 502, 721 ActionDest: 268 Annotation: Subtype: Link Rect: 474, 699, 486, 708 ActionDest: 268 Annotation: Subtype: Link Rect: 543, 699, 555, 708 ActionDest: 268 Annotation: Subtype: Link Rect: 252, 686, 264, 695 ActionDest: 268 Annotation: Subtype: Link Rect: 264, 686, 276, 695 ActionDest: 268 Annotation: Subtype: Link Rect: 379, 686, 391, 695 ActionDest: 268 Annotation: Subtype: Link Rect: 394, 686, 406, 695 ActionDest: 268 Annotation: Subtype: Link Rect: 428, 674, 440, 683 ActionDest: 268 Annotation: Subtype: Link Rect: 381, 661, 393, 670 ActionDest: 268 Annotation: Subtype: Link Rect: 479, 586, 490, 595 ActionDest: 268 Annotation: Subtype: Link Rect: 531, 561, 543, 570 ActionDest: 268 Annotation: Subtype: Link Rect: 544, 561, 556, 570 ActionDest: 268 Annotation: Subtype: Link Rect: 353, 523, 365, 532 ActionDest: 268 Annotation: Subtype: Link Rect: 368, 523, 380, 532 ActionDest: 271 Annotation: Subtype: Link Rect: 357, 473, 369, 482 ActionDest: 271 Annotation: Subtype: Link Rect: 369, 473, 381, 482 ActionDest: 271 Annotation: Subtype: Link Rect: 236, 435, 248, 444 ActionDest: 271 Annotation: Subtype: Link Rect: 317, 410, 329, 419 ActionDest: 271 Annotation: Subtype: Link Rect: 387, 350, 393, 358 ActionDest: 268 Annotation: Subtype: Link Rect: 396, 350, 407, 358 ActionDest: 268 Annotation: Subtype: Link Rect: 407, 350, 418, 358 ActionDest: 271 Annotation: Subtype: Link Rect: 420, 350, 431, 358 ActionDest: 271 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 496, 719, 508, 728 ActionDest: 271 Annotation: Subtype: Link Rect: 486, 707, 493, 716 ActionDest: 268 Annotation: Subtype: Link Rect: 435, 694, 447, 703 ActionDest: 271 Annotation: Subtype: Link Rect: 202, 682, 214, 691 ActionDest: 271 Annotation: Subtype: Link Rect: 515, 682, 527, 691 ActionDest: 271 Annotation: Subtype: Link Rect: 358, 631, 370, 640 ActionDest: 271 Annotation: Subtype: Link Rect: 371, 631, 383, 640 ActionDest: 271 Annotation: Subtype: Link Rect: 255, 619, 267, 628 ActionDest: 271 Annotation: Subtype: Link Rect: 460, 619, 472, 628 ActionDest: 271 Annotation: Subtype: Link Rect: 473, 619, 485, 628 ActionDest: 271 Annotation: Subtype: Link Rect: 323, 581, 335, 590 ActionDest: 271 Annotation: Subtype: Link Rect: 335, 581, 347, 590 ActionDest: 271 Annotation: Subtype: Link Rect: 348, 581, 359, 590 ActionDest: 271 Annotation: Subtype: Link Rect: 362, 581, 374, 590 ActionDest: 271 Annotation: Subtype: Link Rect: 406, 556, 418, 565 ActionDest: 271 Annotation: Subtype: Link Rect: 419, 556, 431, 565 ActionDest: 271 Annotation: Subtype: Link Rect: 496, 518, 508, 527 ActionDest: 275 Annotation: Subtype: Link Rect: 325, 465, 332, 477 ActionDest: 82 Annotation: Subtype: Link Rect: 526, 443, 533, 452 ActionDest: 268 Annotation: Subtype: Link Rect: 533, 443, 545, 452 ActionDest: 275 Annotation: Subtype: Link Rect: 480, 380, 492, 389 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 292, 519, 301 ActionDest: 268 Annotation: Subtype: Link Rect: 520, 292, 532, 301 ActionDest: 275 Annotation: Subtype: Link Rect: 343, 254, 355, 263 ActionDest: 275 Annotation: Subtype: Link Rect: 449, 229, 461, 238 ActionDest: 271 Annotation: Subtype: Link Rect: 544, 179, 556, 188 ActionDest: 275 Annotation: Subtype: Link Rect: 531, 103, 543, 112 ActionDest: 275 Annotation: Subtype: Link Rect: 544, 103, 556, 112 ActionDest: 275 Annotation: Subtype: Link Rect: 329, 66, 341, 75 ActionDest: 271 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 206, 707, 218, 716 ActionDest: 271 Annotation: Subtype: Link Rect: 218, 707, 230, 716 ActionDest: 275 Annotation: Subtype: Link Rect: 233, 707, 245, 716 ActionDest: 275 Annotation: Subtype: Link Rect: 297, 682, 309, 691 ActionDest: 271 Annotation: Subtype: Link Rect: 255, 656, 267, 666 ActionDest: 271 Annotation: Subtype: Link Rect: 213, 619, 220, 628 ActionDest: 268 Annotation: Subtype: Link Rect: 221, 619, 233, 628 ActionDest: 271 Annotation: Subtype: Link Rect: 433, 606, 445, 615 ActionDest: 275 Annotation: Subtype: Link Rect: 258, 569, 270, 578 ActionDest: 275 Annotation: Subtype: Link Rect: 356, 541, 363, 553 ActionDest: 92 Annotation: Subtype: Link Rect: 356, 506, 368, 515 ActionDest: 275 Annotation: Subtype: Link Rect: 400, 468, 412, 477 ActionDest: 271 Annotation: Subtype: Link Rect: 512, 389, 522, 396 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 379, 522, 387 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 370, 522, 377 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 360, 522, 368 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 336, 522, 344 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 327, 522, 335 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 313, 522, 320 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 299, 522, 306 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 289, 522, 297 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 275, 522, 283 ActionDest: 275 Annotation: Subtype: Link Rect: 512, 261, 522, 268 ActionDest: 275 Annotation: Subtype: Link Rect: 507, 247, 517, 254 ActionDest: 278 Annotation: Subtype: Link Rect: 517, 247, 527, 254 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 223, 522, 230 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 204, 522, 212 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 185, 522, 193 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 171, 522, 178 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 161, 522, 169 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 147, 522, 155 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 133, 522, 141 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 109, 522, 117 ActionDest: 278 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 359, 704, 366, 716 ActionDest: 95 Annotation: Subtype: Link Rect: 514, 669, 526, 678 ActionDest: 268 Annotation: Subtype: Link Rect: 527, 669, 539, 678 ActionDest: 278 Annotation: Subtype: Link Rect: 208, 606, 220, 615 ActionDest: 278 Annotation: Subtype: Link Rect: 289, 569, 301, 578 ActionDest: 278 Annotation: Subtype: Link Rect: 301, 569, 313, 578 ActionDest: 278 Annotation: Subtype: Link Rect: 313, 532, 320, 540 ActionDest: 268 Annotation: Subtype: Link Rect: 322, 532, 329, 540 ActionDest: 268 Annotation: Subtype: Link Rect: 329, 532, 340, 540 ActionDest: 268 Annotation: Subtype: Link Rect: 342, 532, 353, 540 ActionDest: 268 Annotation: Subtype: Link Rect: 353, 532, 364, 540 ActionDest: 271 Annotation: Subtype: Link Rect: 367, 532, 378, 540 ActionDest: 271 Annotation: Subtype: Link Rect: 378, 532, 389, 540 ActionDest: 278 Annotation: Subtype: Link Rect: 389, 532, 400, 540 ActionDest: 278 Annotation: Subtype: Link Rect: 403, 532, 418, 540 ActionDest: 281 Annotation: Subtype: Link Rect: 200, 311, 212, 320 ActionDest: 278 Annotation: Subtype: Link Rect: 212, 311, 224, 320 ActionDest: 278 Annotation: Subtype: Link Rect: 303, 274, 320, 283 ActionDest: 281 Annotation: Subtype: Link Rect: 538, 261, 555, 270 ActionDest: 281 Annotation: Subtype: Link Rect: 238, 186, 255, 195 ActionDest: 281 Annotation: Subtype: Link Rect: 258, 186, 275, 195 ActionDest: 281 Annotation: Subtype: Link Rect: 395, 186, 407, 195 ActionDest: 278 Annotation: Subtype: Link Rect: 187, 173, 204, 182 ActionDest: 281 Annotation: Subtype: Link Rect: 275, 161, 287, 170 ActionDest: 275 Annotation: Subtype: Link Rect: 523, 161, 535, 170 ActionDest: 278 Annotation: Subtype: Link Rect: 377, 148, 394, 157 ActionDest: 281 Annotation: Subtype: Link Rect: 466, 98, 478, 107 ActionDest: 268 Annotation: Subtype: Link Rect: 224, 85, 236, 94 ActionDest: 278 Annotation: Subtype: Link Rect: 539, 60, 556, 69 ActionDest: 281 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 240, 722, 257, 731 ActionDest: 281 Annotation: Subtype: Link Rect: 340, 697, 357, 706 ActionDest: 281 Annotation: Subtype: Link Rect: 260, 672, 277, 681 ActionDest: 281 Annotation: Subtype: Link Rect: 526, 609, 543, 618 ActionDest: 281 Annotation: Subtype: Link Rect: 329, 559, 346, 568 ActionDest: 281 Annotation: Subtype: Link Rect: 481, 471, 498, 480 ActionDest: 281 Annotation: Subtype: Link Rect: 222, 446, 239, 455 ActionDest: 281 Annotation: Subtype: Link Rect: 372, 345, 388, 354 ActionDest: 281 Annotation: Subtype: Link Rect: 274, 307, 291, 316 ActionDest: 281 Annotation: Subtype: Link Rect: 473, 294, 490, 303 ActionDest: 281 Annotation: Subtype: Link Rect: 493, 294, 510, 303 ActionDest: 284 Annotation: Subtype: Link Rect: 498, 257, 515, 266 ActionDest: 284 Annotation: Subtype: Link Rect: 516, 257, 533, 266 ActionDest: 284 Annotation: Subtype: Link Rect: 300, 194, 317, 203 ActionDest: 284 Annotation: Subtype: Link Rect: 320, 194, 337, 203 ActionDest: 284 Annotation: Subtype: Link Rect: 415, 106, 432, 115 ActionDest: 284 Annotation: Subtype: Link Rect: 435, 106, 452, 115 ActionDest: 284 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 210, 722, 227, 731 ActionDest: 284 Annotation: Subtype: Link Rect: 230, 722, 247, 731 ActionDest: 284 Annotation: Subtype: Link Rect: 445, 647, 462, 656 ActionDest: 284 Annotation: Subtype: Link Rect: 463, 647, 479, 656 ActionDest: 284 Annotation: Subtype: Link Rect: 472, 571, 489, 580 ActionDest: 284 Annotation: Subtype: Link Rect: 276, 421, 293, 430 ActionDest: 284 Annotation: Subtype: Link Rect: 262, 370, 279, 380 ActionDest: 284 Annotation: Subtype: Link Rect: 280, 371, 297, 380 ActionDest: 284 Annotation: Subtype: Link Rect: 387, 308, 404, 317 ActionDest: 284 Annotation: Subtype: Link Rect: 405, 308, 422, 317 ActionDest: 284 Annotation: Subtype: Link Rect: 313, 258, 330, 267 ActionDest: 284 Annotation: Subtype: Link Rect: 528, 195, 545, 204 ActionDest: 284 Annotation: Subtype: Link Rect: 261, 107, 278, 116 ActionDest: 284 Annotation: Subtype: Link Rect: 281, 107, 298, 116 ActionDest: 284 Annotation: Subtype: Link Rect: 471, 82, 488, 91 ActionDest: 284 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 539, 722, 556, 731 ActionDest: 284 Annotation: Subtype: Link Rect: 513, 672, 530, 681 ActionDest: 284 Annotation: Subtype: Link Rect: 506, 647, 523, 656 ActionDest: 284 Annotation: Subtype: Link Rect: 462, 609, 479, 618 ActionDest: 284 Annotation: Subtype: Link Rect: 343, 521, 360, 530 ActionDest: 287 Annotation: Subtype: Link Rect: 361, 521, 378, 530 ActionDest: 287 Annotation: Subtype: Link Rect: 190, 471, 207, 480 ActionDest: 287 Annotation: Subtype: Link Rect: 208, 471, 225, 480 ActionDest: 287 Annotation: Subtype: Link Rect: 319, 458, 336, 467 ActionDest: 287 Annotation: Subtype: Link Rect: 336, 458, 353, 467 ActionDest: 287 Annotation: Subtype: Link Rect: 439, 371, 456, 380 ActionDest: 281 Annotation: Subtype: Link Rect: 285, 358, 302, 367 ActionDest: 287 Annotation: Subtype: Link Rect: 506, 320, 523, 329 ActionDest: 287 Annotation: Subtype: Link Rect: 209, 295, 226, 304 ActionDest: 287 Annotation: Subtype: Link Rect: 229, 295, 246, 304 ActionDest: 287 Annotation: Subtype: Link Rect: 293, 257, 310, 267 ActionDest: 287 Annotation: Subtype: Link Rect: 284, 207, 301, 216 ActionDest: 287 Annotation: Subtype: Link Rect: 391, 195, 408, 204 ActionDest: 287 Annotation: Subtype: Link Rect: 209, 170, 226, 179 ActionDest: 287 Annotation: Subtype: Link Rect: 197, 144, 214, 154 ActionDest: 287 Annotation: Subtype: Link Rect: 508, 145, 525, 154 ActionDest: 287 Annotation: Subtype: Link Rect: 460, 82, 477, 91 ActionDest: 287 Annotation: Subtype: Link Rect: 478, 82, 495, 91 ActionDest: 287 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 255, 722, 272, 731 ActionDest: 284 Annotation: Subtype: Link Rect: 321, 697, 338, 706 ActionDest: 287 Annotation: Subtype: Link Rect: 239, 672, 256, 681 ActionDest: 287 Annotation: Subtype: Link Rect: 509, 659, 526, 669 ActionDest: 287 Annotation: Subtype: Link Rect: 219, 622, 236, 631 ActionDest: 287 Annotation: Subtype: Link Rect: 372, 584, 389, 593 ActionDest: 287 Annotation: Subtype: Link Rect: 273, 547, 290, 556 ActionDest: 287 Annotation: Subtype: Link Rect: 411, 521, 428, 530 ActionDest: 287 Annotation: Subtype: Link Rect: 388, 496, 405, 505 ActionDest: 284 Annotation: Subtype: Link Rect: 335, 471, 352, 480 ActionDest: 281 Annotation: Subtype: Link Rect: 352, 471, 369, 480 ActionDest: 287 Annotation: Subtype: Link Rect: 289, 421, 305, 430 ActionDest: 287 Annotation: Subtype: Link Rect: 538, 421, 555, 430 ActionDest: 287 Annotation: Subtype: Link Rect: 316, 396, 333, 405 ActionDest: 294 Annotation: Subtype: Link Rect: 359, 371, 376, 380 ActionDest: 287 Annotation: Subtype: Link Rect: 517, 358, 534, 367 ActionDest: 284 Annotation: Subtype: Link Rect: 535, 358, 552, 367 ActionDest: 294 Annotation: Subtype: Link Rect: 496, 308, 513, 317 ActionDest: 294 Annotation: Subtype: Link Rect: 492, 295, 508, 304 ActionDest: 294 Annotation: Subtype: Link Rect: 495, 283, 512, 292 ActionDest: 294 Annotation: Subtype: Link Rect: 251, 245, 268, 254 ActionDest: 284 Annotation: Subtype: Link Rect: 268, 245, 285, 254 ActionDest: 294 Annotation: Subtype: Link Rect: 213, 220, 230, 229 ActionDest: 284 Annotation: Subtype: Link Rect: 231, 220, 247, 229 ActionDest: 294 Annotation: Subtype: Link Rect: 340, 208, 357, 217 ActionDest: 294 Annotation: Subtype: Link Rect: 262, 182, 279, 192 ActionDest: 294 Annotation: Subtype: Link Rect: 384, 157, 401, 166 ActionDest: 294 Annotation: Subtype: Link Rect: 381, 132, 398, 141 ActionDest: 294 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 377, 732, 384, 744 ActionDest: 117 Annotation: Subtype: Link Rect: 446, 710, 463, 719 ActionDest: 294 Annotation: Subtype: Link Rect: 193, 672, 205, 681 ActionDest: 278 Annotation: Subtype: Link Rect: 292, 634, 303, 643 ActionDest: 278 Annotation: Subtype: Link Rect: 411, 622, 428, 631 ActionDest: 294 Annotation: Subtype: Link Rect: 228, 521, 240, 530 ActionDest: 278 Annotation: Subtype: Link Rect: 264, 496, 276, 505 ActionDest: 278 Annotation: Subtype: Link Rect: 378, 496, 390, 505 ActionDest: 278 Annotation: Subtype: Link Rect: 509, 446, 521, 455 ActionDest: 278 Annotation: Subtype: Link Rect: 253, 421, 270, 430 ActionDest: 294 Annotation: Subtype: Link Rect: 262, 371, 274, 380 ActionDest: 275 Annotation: Subtype: Link Rect: 275, 371, 286, 380 ActionDest: 275 Annotation: Subtype: Link Rect: 287, 371, 298, 380 ActionDest: 278 Annotation: Subtype: Link Rect: 299, 371, 316, 380 ActionDest: 294 Annotation: Subtype: Link Rect: 316, 371, 333, 380 ActionDest: 294 Annotation: Subtype: Link Rect: 486, 371, 498, 380 ActionDest: 275 Annotation: Subtype: Link Rect: 498, 371, 510, 380 ActionDest: 275 Annotation: Subtype: Link Rect: 510, 371, 522, 380 ActionDest: 278 Annotation: Subtype: Link Rect: 522, 371, 539, 380 ActionDest: 294 Annotation: Subtype: Link Rect: 539, 371, 556, 380 ActionDest: 294 Annotation: Subtype: Link Rect: 317, 333, 333, 342 ActionDest: 294 Annotation: Subtype: Link Rect: 385, 333, 401, 342 ActionDest: 294 Annotation: Subtype: Link Rect: 432, 320, 443, 330 ActionDest: 275 Annotation: Subtype: Link Rect: 298, 295, 310, 304 ActionDest: 275 Annotation: Subtype: Link Rect: 311, 295, 328, 304 ActionDest: 294 Annotation: Subtype: Link Rect: 349, 270, 366, 279 ActionDest: 294 Annotation: Subtype: Link Rect: 319, 120, 336, 129 ActionDest: 294 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 245, 735, 262, 744 ActionDest: 294 Annotation: Subtype: Link Rect: 393, 722, 405, 731 ActionDest: 278 Annotation: Subtype: Link Rect: 219, 710, 236, 719 ActionDest: 294 Annotation: Subtype: Link Rect: 211, 609, 223, 618 ActionDest: 271 Annotation: Subtype: Link Rect: 223, 609, 235, 618 ActionDest: 271 Annotation: Subtype: Link Rect: 238, 609, 250, 618 ActionDest: 271 Annotation: Subtype: Link Rect: 251, 609, 268, 618 ActionDest: 294 Annotation: Subtype: Link Rect: 391, 594, 398, 606 ActionDest: 117 Annotation: Subtype: Link Rect: 307, 534, 319, 543 ActionDest: 278 Annotation: Subtype: Link Rect: 246, 496, 258, 505 ActionDest: 278 Annotation: Subtype: Link Rect: 461, 458, 473, 467 ActionDest: 278 Annotation: Subtype: Link Rect: 483, 433, 495, 442 ActionDest: 278 Annotation: Subtype: Link Rect: 491, 421, 503, 430 ActionDest: 278 Annotation: Subtype: Link Rect: 430, 333, 441, 342 ActionDest: 281 Annotation: Subtype: Link Rect: 445, 333, 461, 342 ActionDest: 281 Annotation: Subtype: Link Rect: 396, 320, 413, 329 ActionDest: 281 Annotation: Subtype: Link Rect: 250, 295, 266, 304 ActionDest: 294 Annotation: Subtype: Link Rect: 267, 295, 284, 304 ActionDest: 294 Annotation: Subtype: Link Rect: 242, 270, 259, 279 ActionDest: 294 Annotation: Subtype: Link Rect: 377, 182, 394, 191 ActionDest: 294 Annotation: Subtype: Link Rect: 441, 157, 458, 166 ActionDest: 294 Annotation: Subtype: Link Rect: 521, 69, 538, 78 ActionDest: 297 Annotation: Subtype: Link Rect: 539, 69, 556, 78 ActionDest: 297 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 359, 697, 376, 706 ActionDest: 297 Annotation: Subtype: Link Rect: 377, 697, 394, 706 ActionDest: 297 Annotation: Subtype: Link Rect: 539, 672, 556, 681 ActionDest: 297 Annotation: Subtype: Link Rect: 380, 634, 392, 643 ActionDest: 278 Annotation: Subtype: Link Rect: 362, 572, 379, 581 ActionDest: 297 Annotation: Subtype: Link Rect: 380, 572, 397, 581 ActionDest: 297 Annotation: Subtype: Link Rect: 510, 487, 525, 496 ActionDest: 294 Annotation: Subtype: Link Rect: 512, 476, 523, 485 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 465, 523, 474 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 454, 523, 463 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 443, 523, 452 ActionDest: 278 Annotation: Subtype: Link Rect: 510, 432, 525, 441 ActionDest: 294 Annotation: Subtype: Link Rect: 512, 421, 523, 430 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 406, 523, 414 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 395, 523, 403 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 379, 523, 387 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 368, 523, 376 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 357, 523, 365 ActionDest: 278 Annotation: Subtype: Link Rect: 512, 346, 523, 354 ActionDest: 278 Annotation: Subtype: Link Rect: 510, 335, 525, 344 ActionDest: 294 Annotation: Subtype: Link Rect: 510, 324, 525, 333 ActionDest: 297 Annotation: Subtype: Link Rect: 275, 291, 282, 303 ActionDest: 120 Annotation: Subtype: Link Rect: 358, 194, 375, 203 ActionDest: 297 Annotation: Subtype: Link Rect: 472, 168, 489, 177 ActionDest: 297 Annotation: Subtype: Link Rect: 291, 143, 308, 152 ActionDest: 297 Annotation: Subtype: Link Rect: 431, 131, 448, 140 ActionDest: 297 Annotation: Subtype: Link Rect: 259, 106, 276, 115 ActionDest: 297 Annotation: Subtype: Link Rect: 277, 106, 293, 115 ActionDest: 297 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 354, 284, 366, 293 ActionDest: 271 Annotation: Subtype: Link Rect: 367, 284, 379, 293 ActionDest: 271 Annotation: Subtype: Link Rect: 519, 272, 536, 281 ActionDest: 297 Annotation: Subtype: Link Rect: 539, 272, 556, 281 ActionDest: 297 Annotation: Subtype: Link Rect: 259, 171, 276, 180 ActionDest: 297 Annotation: Subtype: Link Rect: 212, 134, 229, 143 ActionDest: 297 Annotation: Subtype: Link Rect: 298, 96, 315, 105 ActionDest: 297 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 523, 647, 540, 656 ActionDest: 297 Annotation: Subtype: Link Rect: 340, 622, 357, 631 ActionDest: 281 Annotation: Subtype: Link Rect: 409, 584, 426, 593 ActionDest: 297 Annotation: Subtype: Link Rect: 419, 559, 436, 568 ActionDest: 297 Annotation: Subtype: Link Rect: 236, 547, 253, 556 ActionDest: 297 Annotation: Subtype: Link Rect: 396, 396, 413, 405 ActionDest: 297 Annotation: Subtype: Link Rect: 425, 308, 442, 317 ActionDest: 297 Annotation: Subtype: Link Rect: 420, 231, 437, 241 ActionDest: 281 Annotation: Subtype: Link Rect: 438, 231, 455, 241 ActionDest: 284 Annotation: Subtype: Link Rect: 455, 231, 472, 241 ActionDest: 297 Annotation: Subtype: Link Rect: 473, 232, 490, 241 ActionDest: 297 Annotation: Subtype: Link Rect: 457, 206, 474, 215 ActionDest: 297 Annotation: Subtype: Link Rect: 474, 206, 491, 215 ActionDest: 297 Annotation: Subtype: Link Rect: 186, 181, 203, 190 ActionDest: 297 Annotation: Subtype: Link Rect: 204, 181, 221, 190 ActionDest: 297 Annotation: Subtype: Link Rect: 221, 181, 238, 190 ActionDest: 300 Annotation: Subtype: Link Rect: 378, 169, 395, 178 ActionDest: 297 Annotation: Subtype: Link Rect: 385, 156, 402, 165 ActionDest: 297 Annotation: Subtype: Link Rect: 318, 131, 335, 140 ActionDest: 297 Annotation: Subtype: Link Rect: 336, 131, 353, 140 ActionDest: 297 Annotation: Subtype: Link Rect: 332, 93, 349, 102 ActionDest: 297 Annotation: Subtype: Link Rect: 352, 93, 369, 102 ActionDest: 300 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 320, 735, 337, 744 ActionDest: 300 Annotation: Subtype: Link Rect: 337, 735, 354, 744 ActionDest: 300 Annotation: Subtype: Link Rect: 349, 710, 366, 719 ActionDest: 300 Annotation: Subtype: Link Rect: 364, 672, 381, 681 ActionDest: 300 Annotation: Subtype: Link Rect: 382, 672, 399, 681 ActionDest: 300 Annotation: Subtype: Link Rect: 539, 647, 556, 656 ActionDest: 300 Annotation: Subtype: Link Rect: 539, 609, 556, 618 ActionDest: 300 Annotation: Subtype: Link Rect: 383, 584, 400, 593 ActionDest: 300 Annotation: Subtype: Link Rect: 401, 584, 418, 593 ActionDest: 300 Annotation: Subtype: Link Rect: 333, 547, 349, 556 ActionDest: 300 Annotation: Subtype: Link Rect: 350, 546, 367, 556 ActionDest: 300 Annotation: Subtype: Link Rect: 417, 521, 434, 530 ActionDest: 300 Annotation: Subtype: Link Rect: 434, 521, 451, 530 ActionDest: 300 Annotation: Subtype: Link Rect: 422, 484, 439, 493 ActionDest: 300 Annotation: Subtype: Link Rect: 539, 383, 556, 392 ActionDest: 300 Annotation: Subtype: Link Rect: 521, 358, 538, 367 ActionDest: 300 Annotation: Subtype: Link Rect: 539, 358, 556, 367 ActionDest: 300 Annotation: Subtype: Link Rect: 396, 345, 413, 354 ActionDest: 300 Annotation: Subtype: Link Rect: 444, 333, 461, 342 ActionDest: 303 Annotation: Subtype: Link Rect: 205, 295, 222, 304 ActionDest: 303 Annotation: Subtype: Link Rect: 222, 295, 239, 304 ActionDest: 303 Annotation: Subtype: Link Rect: 491, 283, 508, 292 ActionDest: 303 Annotation: Subtype: Link Rect: 539, 245, 556, 254 ActionDest: 303 Annotation: Subtype: Link Rect: 479, 232, 496, 241 ActionDest: 303 Annotation: Subtype: Link Rect: 398, 220, 415, 229 ActionDest: 303 Annotation: Subtype: Link Rect: 377, 207, 394, 216 ActionDest: 303 Annotation: Subtype: Link Rect: 432, 182, 449, 191 ActionDest: 303 Annotation: Subtype: Link Rect: 508, 144, 525, 154 ActionDest: 303 Annotation: Subtype: Link Rect: 441, 94, 457, 103 ActionDest: 303 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 477, 656, 489, 666 ActionDest: 278 Annotation: Subtype: Link Rect: 489, 656, 506, 666 ActionDest: 294 Annotation: Subtype: Link Rect: 507, 657, 524, 666 ActionDest: 297 Annotation: Subtype: Link Rect: 381, 631, 398, 640 ActionDest: 297 Annotation: Subtype: Link Rect: 399, 631, 415, 640 ActionDest: 297 Annotation: Subtype: Link Rect: 416, 631, 433, 640 ActionDest: 297 Annotation: Subtype: Link Rect: 433, 631, 450, 640 ActionDest: 297 Annotation: Subtype: Link Rect: 349, 569, 361, 578 ActionDest: 278 Annotation: Subtype: Link Rect: 243, 506, 255, 515 ActionDest: 275 Annotation: Subtype: Link Rect: 256, 506, 267, 515 ActionDest: 278 Annotation: Subtype: Link Rect: 268, 506, 285, 515 ActionDest: 294 Annotation: Subtype: Link Rect: 225, 493, 237, 502 ActionDest: 275 Annotation: Subtype: Link Rect: 238, 493, 255, 502 ActionDest: 294 Annotation: Subtype: Link Rect: 255, 493, 272, 502 ActionDest: 303 Annotation: Subtype: Link Rect: 273, 493, 289, 502 ActionDest: 303 Annotation: Subtype: Link Rect: 485, 481, 497, 490 ActionDest: 275 Annotation: Subtype: Link Rect: 381, 418, 393, 427 ActionDest: 278 Annotation: Subtype: Link Rect: 209, 317, 226, 326 ActionDest: 294 Annotation: Subtype: Link Rect: 199, 229, 215, 238 ActionDest: 297 Annotation: Subtype: Link Rect: 216, 229, 233, 238 ActionDest: 300 Annotation: Subtype: Link Rect: 501, 204, 513, 213 ActionDest: 278 Annotation: Subtype: Link Rect: 513, 204, 525, 213 ActionDest: 278 Annotation: Subtype: Link Rect: 526, 204, 538, 213 ActionDest: 278 Annotation: Subtype: Link Rect: 538, 204, 555, 213 ActionDest: 294 Annotation: Subtype: Link Rect: 393, 141, 410, 151 ActionDest: 303 Annotation: Subtype: Link Rect: 411, 141, 428, 151 ActionDest: 303 Annotation: Subtype: Link Rect: 378, 79, 395, 88 ActionDest: 303 Annotation: Subtype: Link Rect: 395, 79, 412, 88 ActionDest: 303 Annotation: Subtype: Link Rect: 415, 79, 432, 88 ActionDest: 303 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 248, 685, 265, 694 ActionDest: 303 Annotation: Subtype: Link Rect: 413, 682, 420, 694 ActionDest: 204 Annotation: Subtype: Link Rect: 271, 376, 287, 384 ActionDest: 297 Annotation: Subtype: Link Rect: 395, 153, 412, 162 ActionDest: 297 Annotation: Subtype: Link Rect: 455, 128, 472, 137 ActionDest: 303 Annotation: Subtype: Link Rect: 473, 127, 490, 137 ActionDest: 303 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 531, 697, 543, 706 ActionDest: 268 Annotation: Subtype: Link Rect: 539, 672, 556, 681 ActionDest: 303 Annotation: Subtype: Link Rect: 405, 647, 422, 656 ActionDest: 303 Annotation: Subtype: Link Rect: 394, 622, 411, 631 ActionDest: 303 Annotation: Subtype: Link Rect: 336, 484, 353, 493 ActionDest: 294 Page: Sequence: 19 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 59, 580, 97, 590 Annotation: Subtype: Link Rect: 104, 557, 141, 567 Annotation: Subtype: Link Rect: 126, 534, 162, 544 Annotation: Subtype: Link Rect: 218, 510, 255, 521 Annotation: Subtype: Link Rect: 176, 488, 214, 498 Annotation: Subtype: Link Rect: 220, 488, 256, 498 Annotation: Subtype: Link Rect: 404, 475, 441, 486 Annotation: Subtype: Link Rect: 448, 475, 484, 486 Annotation: Subtype: Link Rect: 312, 452, 350, 463 Annotation: Subtype: Link Rect: 281, 429, 318, 440 Annotation: Subtype: Link Rect: 308, 407, 346, 417 Annotation: Subtype: Link Rect: 277, 384, 314, 394 Annotation: Subtype: Link Rect: 95, 361, 133, 371 Annotation: Subtype: Link Rect: 174, 337, 211, 348 Annotation: Subtype: Link Rect: 249, 303, 286, 314 Annotation: Subtype: Link Rect: 293, 303, 329, 314 Annotation: Subtype: Link Rect: 135, 281, 171, 291 Annotation: Subtype: Link Rect: 292, 257, 330, 268 Annotation: Subtype: Link Rect: 401, 234, 438, 245 Annotation: Subtype: Link Rect: 256, 211, 294, 222 Annotation: Subtype: Link Rect: 225, 188, 262, 199 Annotation: Subtype: Link Rect: 228, 165, 266, 176 Annotation: Subtype: Link Rect: 408, 131, 445, 141 Annotation: Subtype: Link Rect: 351, 107, 388, 118 Annotation: Subtype: Link Rect: 220, 73, 257, 84 Annotation: Subtype: Link Rect: 263, 73, 300, 84 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 118, 710, 155, 720 Annotation: Subtype: Link Rect: 161, 710, 197, 720 Annotation: Subtype: Link Rect: 59, 676, 97, 686 Annotation: Subtype: Link Rect: 103, 676, 139, 686 Annotation: Subtype: Link Rect: 273, 640, 310, 651 Annotation: Subtype: Link Rect: 316, 640, 352, 651 Annotation: Subtype: Link Rect: 59, 607, 97, 617 Annotation: Subtype: Link Rect: 103, 607, 139, 617 Annotation: Subtype: Link Rect: 341, 583, 378, 594 Annotation: Subtype: Link Rect: 384, 583, 420, 594 Annotation: Subtype: Link Rect: 104, 561, 141, 571 Annotation: Subtype: Link Rect: 148, 561, 184, 571 Annotation: Subtype: Link Rect: 322, 537, 360, 548 Annotation: Subtype: Link Rect: 131, 492, 168, 502 Annotation: Subtype: Link Rect: 212, 468, 249, 479 Annotation: Subtype: Link Rect: 255, 468, 291, 479 Annotation: Subtype: Link Rect: 520, 445, 557, 456 Annotation: Subtype: Link Rect: 59, 434, 95, 444 Annotation: Subtype: Link Rect: 108, 400, 146, 410 Annotation: Subtype: Link Rect: 382, 376, 420, 387 Annotation: Subtype: Link Rect: 426, 376, 462, 387 Annotation: Subtype: Link Rect: 326, 353, 363, 364 Annotation: Subtype: Link Rect: 331, 330, 368, 341 Annotation: Subtype: Link Rect: 308, 284, 345, 295 Annotation: Subtype: Link Rect: 352, 284, 388, 295 Annotation: Subtype: Link Rect: 466, 261, 503, 272 Annotation: Subtype: Link Rect: 144, 204, 182, 214 Annotation: Subtype: Link Rect: 267, 180, 304, 191 Annotation: Subtype: Link Rect: 253, 157, 291, 168 Annotation: Subtype: Link Rect: 95, 135, 131, 145 Annotation: Subtype: Link Rect: 459, 89, 496, 99 Annotation: Subtype: Link Rect: 479, 65, 516, 76 Annotation: Subtype: Link Rect: 521, 65, 557, 76 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 113, 722, 150, 732 Annotation: Subtype: Link Rect: 401, 698, 438, 709 Annotation: Subtype: Link Rect: 95, 676, 133, 686 Annotation: Subtype: Link Rect: 59, 653, 97, 663 Annotation: Subtype: Link Rect: 378, 640, 415, 651 Annotation: Subtype: Link Rect: 122, 607, 160, 617 Annotation: Subtype: Link Rect: 222, 572, 260, 582 Annotation: Subtype: Link Rect: 266, 572, 302, 582 Annotation: Subtype: Link Rect: 421, 548, 459, 559 Annotation: Subtype: Link Rect: 430, 537, 467, 548 Annotation: Subtype: Link Rect: 416, 525, 453, 536 Annotation: Subtype: Link Rect: 170, 503, 207, 513 Annotation: Subtype: Link Rect: 95, 480, 133, 490 Annotation: Subtype: Link Rect: 516, 468, 554, 479 Annotation: Subtype: Link Rect: 509, 445, 546, 456 Annotation: Subtype: Link Rect: 179, 423, 216, 433 Annotation: Subtype: Link Rect: 222, 423, 258, 433 Annotation: Subtype: Link Rect: 203, 387, 241, 398 Annotation: Subtype: Link Rect: 247, 387, 283, 398 Annotation: Subtype: Link Rect: 389, 353, 426, 364 Annotation: Subtype: Link Rect: 310, 319, 348, 329 Annotation: Subtype: Link Rect: 354, 319, 390, 329 Annotation: Subtype: Link Rect: 472, 295, 509, 306 Annotation: Subtype: Link Rect: 354, 273, 392, 283 Annotation: Subtype: Link Rect: 475, 249, 512, 260 Annotation: Subtype: Link Rect: 82, 215, 119, 226 Annotation: Subtype: Link Rect: 220, 192, 257, 203 Annotation: Subtype: Link Rect: 263, 192, 299, 203 Annotation: Subtype: Link Rect: 252, 157, 289, 168 Annotation: Subtype: Link Rect: 296, 157, 332, 168 Annotation: Subtype: Link Rect: 183, 123, 221, 134 Annotation: Subtype: Link Rect: 227, 123, 263, 134 Annotation: Subtype: Link Rect: 358, 88, 395, 99 Annotation: Subtype: Link Rect: 402, 88, 438, 99 Page: Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 385, 709, 423, 720 Annotation: Subtype: Link Rect: 429, 709, 465, 720 Annotation: Subtype: Link Rect: 59, 676, 97, 686 Annotation: Subtype: Link Rect: 225, 641, 263, 651 Annotation: Subtype: Link Rect: 269, 641, 305, 651 Annotation: Subtype: Link Rect: 104, 607, 141, 617 Annotation: Subtype: Link Rect: 421, 583, 459, 594 Annotation: Subtype: Link Rect: 519, 560, 557, 571 Annotation: Subtype: Link Rect: 59, 549, 95, 559 Annotation: Subtype: Link Rect: 302, 526, 339, 536 Annotation: Subtype: Link Rect: 345, 526, 381, 536 Annotation: Subtype: Link Rect: 59, 492, 97, 502 Annotation: Subtype: Link Rect: 103, 492, 139, 502 Annotation: Subtype: Link Rect: 371, 456, 409, 467 Annotation: Subtype: Link Rect: 415, 456, 451, 467 Annotation: Subtype: Link Rect: 307, 433, 345, 444 Annotation: Subtype: Link Rect: 351, 433, 387, 444 Annotation: Subtype: Link Rect: 519, 410, 557, 421 Annotation: Subtype: Link Rect: 59, 400, 95, 410 Annotation: Subtype: Link Rect: 273, 376, 310, 387 Annotation: Subtype: Link Rect: 174, 342, 212, 352 Annotation: Subtype: Link Rect: 59, 285, 97, 295 Annotation: Subtype: Link Rect: 59, 250, 97, 260 Annotation: Subtype: Link Rect: 391, 215, 428, 226 Annotation: Subtype: Link Rect: 435, 215, 471, 226 Annotation: Subtype: Link Rect: 171, 192, 208, 203 Annotation: Subtype: Link Rect: 214, 192, 250, 203 Annotation: Subtype: Link Rect: 479, 180, 516, 191 Annotation: Subtype: Link Rect: 521, 180, 557, 191 Annotation: Subtype: Link Rect: 59, 146, 97, 157 Annotation: Subtype: Link Rect: 273, 111, 311, 122 Annotation: Subtype: Link Rect: 312, 88, 350, 99 Annotation: Subtype: Link Rect: 356, 88, 392, 99 Annotation: Subtype: Link Rect: 356, 66, 393, 76 Annotation: Subtype: Link Rect: 400, 66, 436, 76 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 390, 721, 427, 732 Annotation: Subtype: Link Rect: 404, 698, 442, 709 Annotation: Subtype: Link Rect: 448, 698, 484, 709 Annotation: Subtype: Link Rect: 519, 686, 557, 697 Annotation: Subtype: Link Rect: 59, 676, 95, 686 Annotation: Subtype: Link Rect: 127, 653, 164, 663 Annotation: Subtype: Link Rect: 171, 653, 207, 663 Annotation: Subtype: Link Rect: 466, 629, 504, 640 Annotation: Subtype: Link Rect: 341, 606, 379, 617 Annotation: Subtype: Link Rect: 385, 606, 421, 617 Annotation: Subtype: Link Rect: 59, 572, 97, 582 Annotation: Subtype: Link Rect: 198, 549, 236, 559 Annotation: Subtype: Link Rect: 242, 549, 278, 559 Annotation: Subtype: Link Rect: 519, 514, 557, 525 Annotation: Subtype: Link Rect: 59, 503, 95, 513 Annotation: Subtype: Link Rect: 59, 469, 97, 479 Annotation: Subtype: Link Rect: 131, 434, 169, 444 Annotation: Subtype: Link Rect: 505, 410, 542, 421 Annotation: Subtype: Link Rect: 59, 377, 97, 387 Annotation: Subtype: Link Rect: 429, 353, 467, 364 Annotation: Subtype: Link Rect: 473, 353, 509, 364 Annotation: Subtype: Link Rect: 180, 331, 217, 341 Annotation: Subtype: Link Rect: 223, 331, 259, 341 Annotation: Subtype: Link Rect: 150, 308, 188, 318 Annotation: Subtype: Link Rect: 365, 284, 402, 295 Annotation: Subtype: Link Rect: 113, 250, 151, 260 Annotation: Subtype: Link Rect: 157, 250, 193, 260 Annotation: Subtype: Link Rect: 360, 226, 397, 237 Annotation: Subtype: Link Rect: 402, 203, 439, 214 Annotation: Subtype: Link Rect: 199, 169, 237, 180 Annotation: Subtype: Link Rect: 496, 146, 534, 157 Annotation: Subtype: Link Rect: 478, 134, 515, 145 Annotation: Subtype: Link Rect: 521, 134, 557, 145 Annotation: Subtype: Link Rect: 140, 112, 177, 122 Annotation: Subtype: Link Rect: 184, 112, 220, 122 Annotation: Subtype: Link Rect: 520, 100, 557, 111 Annotation: Subtype: Link Rect: 131, 77, 169, 88 Annotation: Subtype: Link Rect: 175, 77, 211, 88 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 59, 722, 97, 732 Annotation: Subtype: Link Rect: 103, 722, 139, 732 Annotation: Subtype: Link Rect: 457, 709, 494, 720 Annotation: Subtype: Link Rect: 240, 687, 277, 697 Annotation: Subtype: Link Rect: 284, 687, 320, 697 Annotation: Subtype: Link Rect: 457, 663, 494, 674 Annotation: Subtype: Link Rect: 500, 663, 536, 674 Annotation: Subtype: Link Rect: 385, 640, 422, 651 Annotation: Subtype: Link Rect: 428, 640, 464, 651 Annotation: Subtype: Link Rect: 325, 606, 363, 617 Annotation: Subtype: Link Rect: 247, 571, 285, 582 Annotation: Subtype: Link Rect: 291, 571, 327, 582 Annotation: Subtype: Link Rect: 519, 560, 557, 571 Annotation: Subtype: Link Rect: 59, 549, 95, 559 Annotation: Subtype: Link Rect: 95, 526, 132, 536 Annotation: Subtype: Link Rect: 139, 526, 175, 536 Annotation: Subtype: Link Rect: 441, 514, 478, 525 Annotation: Subtype: Link Rect: 484, 514, 520, 525 Annotation: Subtype: Link Rect: 59, 492, 97, 502 Annotation: Subtype: Link Rect: 103, 492, 139, 502 Annotation: Subtype: Link Rect: 180, 468, 218, 479 Annotation: Subtype: Link Rect: 224, 468, 260, 479 Annotation: Subtype: Link Rect: 131, 446, 169, 456 Annotation: Subtype: Link Rect: 175, 446, 211, 456 Annotation: Subtype: Link Rect: 285, 422, 323, 433 Annotation: Subtype: Link Rect: 270, 399, 308, 410 Annotation: Subtype: Link Rect: 314, 399, 350, 410 Annotation: Subtype: Link Rect: 172, 376, 210, 387 Annotation: Subtype: Link Rect: 362, 353, 400, 364 Annotation: Subtype: Link Rect: 406, 353, 442, 364 Annotation: Subtype: Link Rect: 59, 331, 97, 341 Annotation: Subtype: Link Rect: 59, 308, 97, 318 Annotation: Subtype: Link Rect: 104, 285, 142, 295 Annotation: Subtype: Link Rect: 235, 261, 272, 272 Annotation: Subtype: Link Rect: 278, 261, 314, 272 Annotation: Subtype: Link Rect: 520, 249, 557, 260 Annotation: Subtype: Link Rect: 59, 238, 95, 249 Annotation: Subtype: Link Rect: 358, 215, 395, 226 Annotation: Subtype: Link Rect: 402, 215, 438, 226 Annotation: Subtype: Link Rect: 105, 192, 142, 203 Annotation: Subtype: Link Rect: 59, 169, 97, 180 Annotation: Subtype: Link Rect: 242, 146, 279, 157 Annotation: Subtype: Link Rect: 245, 123, 282, 134 Annotation: Subtype: Link Rect: 391, 100, 429, 111 Annotation: Subtype: Link Rect: 167, 66, 205, 76 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 104, 710, 141, 720 Annotation: Subtype: Link Rect: 405, 698, 443, 709 Annotation: Subtype: Link Rect: 449, 698, 485, 709 Annotation: Subtype: Link Rect: 478, 675, 515, 686 Annotation: Subtype: Link Rect: 521, 675, 557, 686 Annotation: Subtype: Link Rect: 479, 652, 516, 663 Annotation: Subtype: Link Rect: 521, 652, 557, 663 Annotation: Subtype: Link Rect: 113, 618, 151, 628 Annotation: Subtype: Link Rect: 157, 618, 193, 628 Annotation: Subtype: Link Rect: 196, 595, 233, 605 Annotation: Subtype: Link Rect: 203, 572, 241, 582 Annotation: Subtype: Link Rect: 247, 572, 283, 582 Annotation: Subtype: Link Rect: 479, 560, 516, 571 Annotation: Subtype: Link Rect: 521, 560, 557, 571 Annotation: Subtype: Link Rect: 436, 548, 473, 559 Annotation: Subtype: Link Rect: 466, 537, 503, 548 Annotation: Subtype: Link Rect: 519, 514, 557, 525 Annotation: Subtype: Link Rect: 59, 503, 95, 513 Annotation: Subtype: Link Rect: 454, 479, 491, 490 Annotation: Subtype: Link Rect: 136, 457, 173, 467 Annotation: Subtype: Link Rect: 179, 457, 216, 467 Annotation: Subtype: Link Rect: 77, 434, 115, 444 Annotation: Subtype: Link Rect: 59, 400, 97, 410 Annotation: Subtype: Link Rect: 433, 387, 471, 398 Annotation: Subtype: Link Rect: 477, 387, 513, 398 Annotation: Subtype: Link Rect: 449, 364, 486, 375 Annotation: Subtype: Link Rect: 59, 331, 97, 341 Annotation: Subtype: Link Rect: 406, 307, 444, 318 Annotation: Subtype: Link Rect: 450, 307, 486, 318 Annotation: Subtype: Link Rect: 238, 284, 276, 295 Annotation: Subtype: Link Rect: 407, 261, 444, 272 Annotation: Subtype: Link Rect: 450, 261, 486, 272 Annotation: Subtype: Link Rect: 369, 238, 406, 249 Annotation: Subtype: Link Rect: 413, 238, 449, 249 Annotation: Subtype: Link Rect: 328, 215, 365, 226 Annotation: Subtype: Link Rect: 424, 192, 461, 203 Annotation: Subtype: Link Rect: 467, 192, 503, 203 Annotation: Subtype: Link Rect: 95, 169, 132, 180 Annotation: Subtype: Link Rect: 165, 135, 202, 145 Annotation: Subtype: Link Rect: 59, 100, 97, 111 Annotation: Subtype: Link Rect: 103, 100, 139, 111 Annotation: Subtype: Link Rect: 298, 77, 335, 88 Annotation: Subtype: Link Rect: 341, 77, 377, 88 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 405, 721, 442, 732 Annotation: Subtype: Link Rect: 448, 721, 484, 732 Annotation: Subtype: Link Rect: 519, 698, 557, 709 Annotation: Subtype: Link Rect: 59, 687, 95, 697 Annotation: Subtype: Link Rect: 210, 653, 247, 663 Annotation: Subtype: Link Rect: 253, 653, 289, 663 Annotation: Subtype: Link Rect: 59, 630, 97, 640 Annotation: Subtype: Link Rect: 398, 606, 436, 617 Annotation: Subtype: Link Rect: 327, 583, 364, 594 Annotation: Subtype: Link Rect: 371, 583, 407, 594 Annotation: Subtype: Link Rect: 487, 560, 525, 571 Annotation: Subtype: Link Rect: 520, 548, 557, 559 Annotation: Subtype: Link Rect: 281, 525, 318, 536 Annotation: Subtype: Link Rect: 292, 491, 330, 502 Annotation: Subtype: Link Rect: 420, 468, 458, 479 Annotation: Subtype: Link Rect: 464, 468, 500, 479 Annotation: Subtype: Link Rect: 394, 445, 432, 456 Annotation: Subtype: Link Rect: 438, 445, 474, 456 Annotation: Subtype: Link Rect: 379, 410, 417, 421 Annotation: Subtype: Link Rect: 275, 388, 313, 398 Annotation: Subtype: Link Rect: 285, 364, 322, 375 Annotation: Subtype: Link Rect: 328, 364, 364, 375 Annotation: Subtype: Link Rect: 59, 331, 97, 341 Annotation: Subtype: Link Rect: 103, 331, 139, 341 Annotation: Subtype: Link Rect: 357, 295, 395, 306 Annotation: Subtype: Link Rect: 59, 262, 97, 272 Annotation: Subtype: Link Rect: 103, 262, 139, 272 Annotation: Subtype: Link Rect: 473, 238, 510, 249 Annotation: Subtype: Link Rect: 516, 238, 552, 249 Annotation: Subtype: Link Rect: 274, 215, 311, 226 Annotation: Subtype: Link Rect: 457, 192, 495, 203 Annotation: Subtype: Link Rect: 501, 192, 537, 203 Annotation: Subtype: Link Rect: 291, 169, 329, 180 Annotation: Subtype: Link Rect: 335, 169, 371, 180 Annotation: Subtype: Link Rect: 240, 135, 278, 145 Annotation: Subtype: Link Rect: 284, 135, 320, 145 Annotation: Subtype: Link Rect: 95, 100, 133, 111 Annotation: Subtype: Link Rect: 59, 66, 97, 76 Page: Sequence: 28 Annotations: Annotation: Subtype: Link Rect: 271, 721, 308, 732 Annotation: Subtype: Link Rect: 104, 687, 141, 697 Annotation: Subtype: Link Rect: 255, 663, 292, 674 Annotation: Subtype: Link Rect: 453, 640, 490, 651 Annotation: Subtype: Link Rect: 285, 618, 322, 628 Annotation: Subtype: Link Rect: 368, 594, 405, 605 Annotation: Subtype: Link Rect: 411, 594, 447, 605 Annotation: Subtype: Link Rect: 423, 571, 460, 582 Annotation: Subtype: Link Rect: 467, 571, 503, 582 Annotation: Subtype: Link Rect: 331, 549, 368, 559 Annotation: Subtype: Link Rect: 374, 549, 410, 559 Annotation: Subtype: Link Rect: 519, 525, 557, 536 Annotation: Subtype: Link Rect: 59, 515, 95, 525 Annotation: Subtype: Link Rect: 59, 480, 97, 490 Annotation: Subtype: Link Rect: 281, 446, 319, 456 Annotation: Subtype: Link Rect: 300, 410, 337, 421 Annotation: Subtype: Link Rect: 343, 410, 379, 421 Annotation: Subtype: Link Rect: 349, 387, 387, 398 Annotation: Subtype: Link Rect: 361, 364, 398, 375 Annotation: Subtype: Link Rect: 59, 319, 97, 329 Annotation: Subtype: Link Rect: 103, 319, 139, 329 Annotation: Subtype: Link Rect: 210, 296, 247, 306 Annotation: Subtype: Link Rect: 253, 296, 289, 306 Annotation: Subtype: Link Rect: 136, 273, 173, 283 Annotation: Subtype: Link Rect: 519, 238, 557, 249 Annotation: Subtype: Link Rect: 59, 227, 95, 237 Annotation: Subtype: Link Rect: 104, 192, 141, 203 Annotation: Subtype: Link Rect: 148, 192, 184, 203 Annotation: Subtype: Link Rect: 203, 169, 240, 180 Annotation: Subtype: Link Rect: 246, 169, 282, 180 Annotation: Subtype: Link Rect: 426, 146, 463, 157 Annotation: Subtype: Link Rect: 469, 146, 505, 157 Annotation: Subtype: Link Rect: 387, 123, 425, 134 Annotation: Subtype: Link Rect: 431, 123, 467, 134 Annotation: Subtype: Link Rect: 95, 100, 133, 111 Annotation: Subtype: Link Rect: 292, 77, 329, 88 Page: Sequence: 29 Annotations: Annotation: Subtype: Link Rect: 269, 709, 307, 720 Annotation: Subtype: Link Rect: 313, 709, 349, 720 Annotation: Subtype: Link Rect: 309, 687, 347, 697 Annotation: Subtype: Link Rect: 457, 663, 494, 674 Annotation: Subtype: Link Rect: 501, 663, 537, 674 Annotation: Subtype: Link Rect: 322, 629, 359, 640 Annotation: Subtype: Link Rect: 104, 595, 141, 605 Annotation: Subtype: Link Rect: 148, 595, 184, 605 Annotation: Subtype: Link Rect: 95, 561, 133, 571 Annotation: Subtype: Link Rect: 139, 561, 175, 571 Annotation: Subtype: Link Rect: 59, 526, 97, 536 Annotation: Subtype: Link Rect: 103, 526, 139, 536 Annotation: Subtype: Link Rect: 519, 502, 557, 513 Annotation: Subtype: Link Rect: 59, 492, 95, 502 Annotation: Subtype: Link Rect: 512, 468, 549, 479 Annotation: Subtype: Link Rect: 145, 434, 182, 444 Annotation: Subtype: Link Rect: 171, 400, 208, 410 Annotation: Subtype: Link Rect: 214, 400, 250, 410 Annotation: Subtype: Link Rect: 519, 376, 557, 387 Annotation: Subtype: Link Rect: 59, 365, 95, 375 Annotation: Subtype: Link Rect: 464, 353, 501, 364 Annotation: Subtype: Link Rect: 508, 353, 544, 364 Annotation: Subtype: Link Rect: 478, 330, 515, 341 Annotation: Subtype: Link Rect: 521, 330, 557, 341 Annotation: Subtype: Link Rect: 59, 296, 97, 306 Annotation: Subtype: Link Rect: 103, 296, 139, 306 Annotation: Subtype: Link Rect: 59, 262, 97, 272 Annotation: Subtype: Link Rect: 103, 262, 139, 272 Annotation: Subtype: Link Rect: 317, 238, 355, 249 Annotation: Subtype: Link Rect: 361, 238, 397, 249 Annotation: Subtype: Link Rect: 59, 215, 97, 226 Annotation: Subtype: Link Rect: 103, 215, 139, 226 Annotation: Subtype: Link Rect: 424, 192, 462, 203 Annotation: Subtype: Link Rect: 468, 192, 504, 203 Annotation: Subtype: Link Rect: 505, 169, 542, 180 Annotation: Subtype: Link Rect: 118, 146, 155, 157 Annotation: Subtype: Link Rect: 304, 111, 342, 122 Annotation: Subtype: Link Rect: 401, 88, 438, 99 Annotation: Subtype: Link Rect: 444, 88, 480, 99 Annotation: Subtype: Link Rect: 264, 65, 302, 76 Annotation: Subtype: Link Rect: 308, 65, 344, 76 Page: Sequence: 30 Annotations: Annotation: Subtype: Link Rect: 122, 722, 160, 732 Annotation: Subtype: Link Rect: 166, 722, 202, 732 Annotation: Subtype: Link Rect: 262, 699, 299, 709 Annotation: Subtype: Link Rect: 306, 699, 342, 709 Annotation: Subtype: Link Rect: 59, 664, 97, 674 Annotation: Subtype: Link Rect: 156, 641, 194, 651 Annotation: Subtype: Link Rect: 200, 641, 236, 651 Annotation: Subtype: Link Rect: 59, 607, 97, 617 Annotation: Subtype: Link Rect: 103, 607, 139, 617 Annotation: Subtype: Link Rect: 59, 572, 97, 582 Annotation: Subtype: Link Rect: 339, 537, 376, 548 Annotation: Subtype: Link Rect: 383, 537, 419, 548 Annotation: Subtype: Link Rect: 459, 514, 497, 525 Annotation: Subtype: Link Rect: 503, 514, 539, 525 Annotation: Subtype: Link Rect: 176, 480, 214, 490 Annotation: Subtype: Link Rect: 220, 480, 256, 490 Annotation: Subtype: Link Rect: 331, 457, 368, 467 Annotation: Subtype: Link Rect: 374, 457, 410, 467 Annotation: Subtype: Link Rect: 175, 434, 213, 444 Annotation: Subtype: Link Rect: 219, 434, 255, 444 Annotation: Subtype: Link Rect: 284, 410, 321, 421 Annotation: Subtype: Link Rect: 327, 410, 363, 421 Annotation: Subtype: Link Rect: 447, 376, 484, 387 Annotation: Subtype: Link Rect: 470, 364, 507, 375 Annotation: Subtype: Link Rect: 203, 296, 241, 306 Annotation: Subtype: Link Rect: 247, 296, 283, 306 Annotation: Subtype: Link Rect: 338, 272, 376, 283 Annotation: Subtype: Link Rect: 382, 272, 418, 283 Annotation: Subtype: Link Rect: 410, 249, 447, 260 Annotation: Subtype: Link Rect: 520, 203, 557, 214 Annotation: Subtype: Link Rect: 285, 180, 323, 191 Annotation: Subtype: Link Rect: 329, 180, 365, 191 Annotation: Subtype: Link Rect: 444, 134, 481, 145 Annotation: Subtype: Link Rect: 487, 134, 523, 145 Checksum: bcccd475 Type: CRC32 Checksum: 604c1a3c983794d118643ef99e216a75 Type: MD5 Checksum: 7488ec948563c6885e071d6764270fee5f1826de Type: SHA-1 Checksum: 3d09f4cfc32368c2007ea4a6d8e1d810c7d6ff8d95269aa66c3723b1a84bce65 Type: SHA-256