d8ef94c7a46f55607898b6004c54451e 255422.pdf ad0d2907d5a1b6081e1d53c7d2661c7b387c8fd1 255422.pdf fa1090bc1f959216bc45381a2e1284df469b8754b7b1c81d07d2ec06bccfef16 255422.pdf Title: A Mitocentric View of the Main Bacterial and Parasitic Infectious Diseases in the Pediatric Population Subject: Infectious diseases occur worldwide with great frequency in both adults and children. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins to the complexes of the electron transport chain, (ii) mitochondrial genome (depletion, deletions, and point mutations) and mitochondrial dynamics (fusion and fission), (iii) membrane potential, (iv) apoptotic regulation, (v) generation of reactive oxygen species, among others. Such alterations may result in serious adverse clinical events with great impact on children’s quality of life, even resulting in death. As such, bacterial agents are frequently associated with loss of mitochondrial membrane potential and cytochrome c release, ultimately leading to mitochondrial apoptosis by activation of caspases-3 and -9. Using Rayyan QCRI software for systematic reviews, we explore the association between mitochondrial alterations and pediatric infections including (i) bacterial: M. tuberculosis, E. cloacae, P. mirabilis, E. coli, S. enterica, S. aureus, S. pneumoniae, N. meningitidis and (ii) parasitic: P. falciparum. We analyze how these pediatric infections and their treatments may lead to mitochondrial deterioration in this especially vulnerable population, with the intention of improving both the understanding of these diseases and their management in clinical practice. Keywords: antibiotics; infections; mitochondria; pediatrics Author: Sonia Romero-Cordero, Richard Kirwan, Antoni Noguera-Julian, Francesc Cardellach, Clàudia Fortuny and Constanza Morén Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Mar 23 13:04:49 2021 CET ModDate: Tue Mar 23 13:12:27 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 41 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2287676 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JJJMXG+URWPalladioL-Ital Type 1 Custom yes yes no 10 0 PFNFMT+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 RCBSSJ+URWPalladioL-Roma Type 1 Custom yes yes no 19 0 MWJZGO+VnURWPalladioL-Bold Type 1 Custom yes yes no 23 0 NQWDWO+VnURWPalladioL Type 1 Custom yes yes no 28 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 36 0 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Introduction Destination: section.1 Item: Title: Mitochondria Destination: section.2 Children: Item: Title: Mitochondrial Structure Destination: subsection.2.1 Children: Item: Title: Outer Mitochondrial Membrane (OMM) Destination: subsubsection.2.1.1 Item: Title: Inner Mitochondrial Membrane (IMM) Destination: subsubsection.2.1.2 Item: Title: Intermembrane Space Destination: subsubsection.2.1.3 Item: Title: Mitochondrial Matrix Destination: subsubsection.2.1.4 Item: Title: Mitochondrial Physiology Destination: subsection.2.2 Item: Title: Mitochondrial Pathology Destination: subsection.2.3 Children: Item: Title: Anaerobiosis Destination: subsubsection.2.3.1 Item: Title: Reactive Oxygen Species Destination: subsubsection.2.3.2 Item: Title: Apoptosis Destination: subsubsection.2.3.3 Item: Title: Bacterial Infectious Processes and Mitochondrial Involvement Destination: section.3 Children: Item: Title: Tuberculosis (TB) Destination: subsection.3.1 Children: Item: Title: Structure and Replication Cycle Destination: subsubsection.3.1.1 Item: Title: TB in the Pediatric Population Destination: subsubsection.3.1.2 Item: Title: Mitochondrial changes in TB infection Destination: subsubsection.3.1.3 Item: Title: TB Treatment in the Pediatric Population and Mitochondrial Involvement Destination: subsubsection.3.1.4 Item: Title: Pediatric Studies of Mitochondrial Interaction in TB Infection Destination: subsubsection.3.1.5 Item: Title: Enterobacteria Destination: subsection.3.2 Item: Title: Staphylococcus aureus Destination: subsection.3.3 Children: Item: Title: Structure and Replication Cycle Destination: subsubsection.3.3.1 Item: Title: Staphylococcus aureus in the Pediatric Population Destination: subsubsection.3.3.2 Item: Title: Mitochondrial Changes in S. aureus Infection Destination: subsubsection.3.3.3 Item: Title: S. aureus Treatment in the Pediatric Population and Mitochondrial Involvement Destination: subsubsection.3.3.4 Item: Title: Pediatric Studies of Mitochondrial Interactions in S. aureus Infection Destination: subsubsection.3.3.5 Item: Title: Meningitis Destination: subsection.3.4 Children: Item: Title: Structure and Replication Cycle Destination: subsubsection.3.4.1 Item: Title: Meningitis in the Pediatric Population Destination: subsubsection.3.4.2 Item: Title: Mitochondrial Changes Derived from Meningitis Pathogens Destination: subsubsection.3.4.3 Item: Title: Meningitis Treatment in the Pediatric Population and Mitochondrial Involvement Destination: subsubsection.3.4.4 Item: Title: Pediatric Studies of Mitochondrial Interaction in Meningitis Infection Destination: subsubsection.3.4.5 Item: Title: Parasitic Infectious Processes and Mitochondrial Involvement Destination: section.4 Children: Item: Title: Malaria Destination: subsection.4.1 Children: Item: Title: Structure and Replication Cycle Destination: subsubsection.4.1.1 Item: Title: Malaria in the Pediatric Population Destination: subsubsection.4.1.2 Item: Title: Mitochondrial Changes in Malaria Infection Destination: subsubsection.4.1.3 Item: Title: Malaria Treatment in the Pediatric Population and Mitochondrial Involvement Destination: subsubsection.4.1.4 Item: Title: Discussion Destination: section.5 Item: Title: Conclusions Destination: section.6 Item: Title: Selection Criteria and Outcomes Destination: section.7 Item: Title: References Destination: section.7 Info: Title: A Mitocentric View of the Main Bacterial and Parasitic Infectious Diseases in the Pediatric Population Author: Sonia Romero-Cordero, Richard Kirwan, Antoni Noguera-Julian, Francesc Cardellach, Clàudia Fortuny and Constanza Morén Subject: Infectious diseases occur worldwide with great frequency in both adults and children. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins to the complexes of the electron transport chain, (ii) mitochondrial genome (depletion, deletions, and point mutations) and mitochondrial dynamics (fusion and fission), (iii) membrane potential, (iv) apoptotic regulation, (v) generation of reactive oxygen species, among others. Such alterations may result in serious adverse clinical events with great impact on children’s quality of life, even resulting in death. As such, bacterial agents are frequently associated with loss of mitochondrial membrane potential and cytochrome c release, ultimately leading to mitochondrial apoptosis by activation of caspases-3 and -9. Using Rayyan QCRI software for systematic reviews, we explore the association between mitochondrial alterations and pediatric infections including (i) bacterial: M. tuberculosis, E. cloacae, P. mirabilis, E. coli, S. enterica, S. aureus, S. pneumoniae, N. meningitidis and (ii) parasitic: P. falciparum. We analyze how these pediatric infections and their treatments may lead to mitochondrial deterioration in this especially vulnerable population, with the intention of improving both the understanding of these diseases and their management in clinical practice. 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Annotation: Subtype: Link Rect: 148, 411, 184, 421 Annotation: Subtype: Link Rect: 140, 388, 178, 398 Annotation: Subtype: Link Rect: 326, 353, 364, 364 Annotation: Subtype: Link Rect: 104, 319, 142, 329 Annotation: Subtype: Link Rect: 59, 296, 97, 306 Annotation: Subtype: Link Rect: 103, 296, 139, 306 Annotation: Subtype: Link Rect: 519, 284, 557, 295 Annotation: Subtype: Link Rect: 59, 273, 95, 283 Annotation: Subtype: Link Rect: 314, 238, 352, 249 Annotation: Subtype: Link Rect: 358, 238, 394, 249 Annotation: Subtype: Link Rect: 285, 215, 323, 226 Annotation: Subtype: Link Rect: 329, 215, 365, 226 Annotation: Subtype: Link Rect: 109, 192, 146, 203 Checksum: c08dbd8e Type: CRC32 Checksum: d8ef94c7a46f55607898b6004c54451e Type: MD5 Checksum: ad0d2907d5a1b6081e1d53c7d2661c7b387c8fd1 Type: SHA-1 Checksum: fa1090bc1f959216bc45381a2e1284df469b8754b7b1c81d07d2ec06bccfef16 Type: SHA-256