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Item: Title: Results Destination: sectionASec3 Item: Title: Conclusions Destination: sectionASec4 Item: Title: Background Destination: sectionSec1 Item: Title: Methods Destination: sectionSec2 Children: Item: Title: Study population Destination: sectionSec3 Item: Title: Head-of-bed manipulation protocol Destination: sectionSec4 Item: Title: Optical methods and instrumentation Destination: sectionSec5 Item: Title: Clinical and imaging evaluation Destination: sectionSec6 Item: Title: Statistical analysis Destination: sectionSec7 Item: Title: Results Destination: sectionSec8 Children: Item: Title: Characteristics of the study population Destination: sectionSec9 Item: Title: Correlation between relative cerebral blood flow changes and relative mean arterial pressure changes during HOB manipulation of position changes Destination: sectionSec10 Item: Title: Discussion Destination: sectionSec11 Item: Title: Conclusions Destination: sectionSec12 Item: Title: Supplementary Information Destination: sectionSec13 Item: Title: Authors’ contributions Destination: section1 Item: Title: Funding Destination: section2 Item: Title: Availability of data and materials Destination: section3 Item: Title: Declarations Destination: section4 Item: Title: Ethics approval and consent to participate Destination: sectionFPar1 Item: Title: Competing interests Destination: sectionFPar2 Item: Title: Author details Destination: section5 Item: Title: References Destination: sectionBib1 Item: Title: Publisher’s Note Destination: ArtNote1 Info: Title: Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease Author: Clara Gregori-Pla Subject: BMC Neurology, 2021, doi:10.1186/s12883-021-02179-8 Keywords: Cerebrovascular disease,Mean arterial pressure,Cerebral blood flow,Cerebral autoregulation,Diffuse correlation spectroscopy,Diffuse optics Creator: Arbortext Advanced Print Publisher 9.1.440/W 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doi:10.1186/s12883-021-02179-8 Cerebrovascular disease Mean arterial pressure Cerebral blood flow Cerebral autoregulation Diffuse correlation spectroscopy Diffuse optics Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease Clara Gregori-Pla Rickson C. Mesquita Christopher G. Favilla David R. Busch Igor Blanco Peyman Zirak Lisa Kobayashi Frisk Stella Avtzi Federica Maruccia Giacomo Giacalone Gianluca Cotta Pol Camps-Renom Michael T. Mullen Joan Martí-Fàbregas Luís Prats-Sánchez Alejandro Martínez-Domeño Scott E. Kasner Joel H. Greenberg Chao Zhou Brian L. Edlow Mary E. Putt John A. Detre Arjun G. 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