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Title:           Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry
Subject:         Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2021, doi:10.1186/s13049-021-00867-5
Keywords:        Massive bleeding,Blood transfusion,Fibrinogen,Factor XIII,Prothrombin complex concentrate,Fluid therapy,Hemostatic resuscitation,Plasma substitutes
Author:          Tobias Koller
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        Title: Background
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       Item: 
        Title: Methods
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       Item: 
        Title: Results
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       Item: 
        Title: Conclusions
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       Item: 
        Title: Trial registration
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     Item: 
      Title: Background
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     Item: 
      Title: Methods
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       Item: 
        Title: Experimental design
        Destination: sectionSec3
       Item: 
        Title: Plasma reference values for thromboelastometry parameters
        Destination: sectionSec4
       Item: 
        Title: Study samples
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        Children: 
         Item: 
          Title: Composition of study samples
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         Item: 
          Title: Preparation of study samples
          Destination: sectionSec7
       Item: 
        Title: Variable CFC concentrations and platelet count
        Destination: sectionSec8
       Item: 
        Title: Preparation of platelet suspensions
        Destination: sectionSec9
       Item: 
        Title: Thromboelastometry
        Destination: sectionSec10
       Item: 
        Title: Statistical analysis
        Destination: sectionSec11
     Item: 
      Title: Results
      Destination: sectionSec12
      Children: 
       Item: 
        Title: Negative control of coagulation factor free AFS samples
        Destination: sectionSec13
       Item: 
        Title: Normal range of plasma tested by TEM
        Destination: sectionSec14
       Item: 
        Title: Combination of PC and FGN leads to fibrin clot formation in a plasma and platelet free environment
        Destination: sectionSec15
       Item: 
        Title: Increasing concentrations of PC caused progressive improvements in TEM parameters at a fixed FGN concentration of 4 g/l
        Destination: sectionSec16
       Item: 
        Title: Rising FGN concentrations improved clot strength related parameters at a fixed PC concentration of 1 IU/ml
        Destination: sectionSec17
       Item: 
        Title: Increasing concentrations of FXIII (0.1, 0.5, 1, 2, 4, 8 IU/ml) enhanced clot strength at fixed concentrations of PC (1 IU/ml) and FGN (4 g/l)
        Destination: sectionSec18
       Item: 
        Title: Platelets completely restore whole blood TEM parameters, including CT
        Destination: sectionSec19
     Item: 
      Title: Discussion
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     Item: 
      Title: Conclusions
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     Item: 
      Title: Abbreviations
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     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
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     Item: 
      Title: Declarations
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      Title: Ethics approval and consent to participate
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     Item: 
      Title: Consent for publication
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     Item: 
      Title: Competing interests
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      Title: Author details
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     Item: 
      Title: References
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