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Keywords: amyotrophic lateral sclerosis, LPA2, lysophosphatidic acid, lysophosphatidic acid receptor, inflammation, motoneuron, muscle atrophy Author: Rubèn López-Vales Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Sat Mar 20 05:58:00 2021 CET ModDate: Sat Mar 20 07:34:03 2021 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 6828201 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FMJFWO+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 729 0 XMMGVM+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 730 0 IAVRZH+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 731 0 RWJPHE+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 732 0 ANRXYW+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 733 0 YVZRIR+MinionPro-Regular Type 1 Custom yes yes no 495 0 NSWVUL+MTSYN Type 1 Builtin yes yes no 496 0 EHGSHB+MinionPro-It Type 1 Custom yes yes no 497 0 YKLLPG+RMTMI Type 1 Builtin yes yes no 494 0 RNVUUZ+MTGU Type 1 Builtin yes yes no 500 0 HPFSDU+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 504 0 WJXIFR+MinionPro-Bold Type 1 Custom yes yes no 507 0 PDNGXR+MTSY Type 1 Builtin yes yes no 513 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:29:48 CEST RepresentationInformation: pmc_33841099.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-04-26 03:40:00 CEST Size: 6828201 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 881 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis Children: Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Human Samples Item: Title: Animals Item: Title: Rotarod and Survival Item: Title: Electrophysiological Test Children: Item: Title: Compound Muscle Action Potential (CMAP) Item: Title: Motor Unit Number Estimation (MUNEs) Item: Title: Sciatic Nerve Injury Item: Title: Quantitative Real-Time PCR (qPCR) Item: Title: Histology Item: Title: Statistical Analysis Item: Title: RESULTS Children: Item: Title: LPA2 Transcripts Are Increased in Human and Mouse ALS Samples Item: Title: Genetic Deletion of Lpar2 Modifies ALS Disease Course Item: Title: LPA2 Does Not Contribute to Motoneuron Death in ALS Item: Title: LPA2 Does Not Promote Myelin Damage in Motor Axons Item: Title: The Absence of Lpar2 Prevents Muscle Atrophy in SOD1G93A Mice Item: Title: Discussion Item: Title: DATA AVAILABILITY STATEMENT Item: Title: ETHICS STATEMENT Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: ACKNOWLEDGMENTS Item: Title: REFERENCES Info: Title: Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis Author: Rubèn López-Vales Subject: Lysophosphatidic acid (LPA) is a pleiotropic extracellular lipid mediator with many physiological functions that signal through six known G protein-coupled receptors (LPA1 6). 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