51d760459fc9f951621f1991a460ffcc  pmc_33866193.pdf
d47e7c6b04ce095f0050d2b9e150d7a1b5a94aa3  pmc_33866193.pdf
523883c257e6cfb49e1bf398addcce7d92f04f579ce5237c10303f044482ca66  pmc_33866193.pdf

Title:          Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
Subject:        EBioMedicine, 66 (2021) 103338. doi:10.1016/j.ebiom.2021.103338
Keywords:       "Spontaneous coronary artery dissection"; "microRNAs"; "Acute myocardial infarction"; "Biomarker"
Author:         Marta Lozano-Prieto
Creator:        Elsevier
Producer:       Acrobat Distiller 10.0.0 (Windows)
CreationDate:   Wed Apr 14 22:35:54 2021 CEST
ModDate:        Wed Apr 14 22:36:26 2021 CEST
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      1662743 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
AJLCLM+AdvOT5fa4e291+fb              Type 1C           Custom           yes yes yes    381  0
AJLCKL+AdvOTf2586c63                 Type 1C           WinAnsi          yes yes no     386  0
AJLCKM+AdvOTf2586c63+fb              Type 1C           Custom           yes yes yes    389  0
AJKLNF+AdvOT5fa4e291                 Type 1C           WinAnsi          yes yes no     394  0
AJLCKK+AdvP4C4E74                    Type 1C           Custom           yes yes yes    397  0
AJLDDK+AdvPAC3D                      Type 1C           WinAnsi          yes yes no     402  0
AJLCJJ+AdvP4C4E59                    Type 1C           Custom           yes yes no     405  0
AJLDNH+AdvTTb83ee1dd.B               Type 1C           WinAnsi          yes yes no     228  0
AJLDOI+AdvOT5fa4e291+20              Type 1C           WinAnsi          yes yes no     231  0
AJLDPJ+AdvP4C9542                    Type 1C           WinAnsi          yes yes no     234  0
AJLDOJ+AdvP4A5FDB                    Type 1C           WinAnsi          yes yes no      24  0
AJMBNP+AdvP4C9543                    Type 1C           WinAnsi          yes yes no      52  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-07-31 02:39:30 CEST
 RepresentationInformation: pmc_33866193.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-05-03 03:53:06 CEST
  Size: 1662743
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 507
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
      Children: 
       Item: 
        Title: 1. Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
       Item: 
        Title: 2. Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
        Children: 
         Item: 
          Title: 2.1. Study design
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
         Item: 
          Title: 2.2. Patients and sample collection
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
         Item: 
          Title: 2.3. Sample size
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: 2.4. Ethics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: 2.5. RNA isolation, RT-PCR and analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
         Item: 
          Title: 2.6. Confirmatory RT-PCR using individual primers
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
         Item: 
          Title: 2.7. ELISA assays
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: 2.8. Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: 2.9. miRNA target identification and their association with biological processes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: 2.10. Role of the funding source
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: 3. Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
        Children: 
         Item: 
          Title: 3.1. Differences in circulating miRNAs profile among SCAD, AT-AMI patients and healthy controls
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: 3.2. SCAD and AT-AMI patients display specific signatures of plasma miRNAs
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: 3.3. Association of miRNA-target genes with blood vessel biology
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: 4. Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
        Children: 
         Item: 
          Title: 4.1. Study limitations
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: 4.2. Contributors
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: 5. Data Sharing Statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
       Item: 
        Title: Declaration of Competing Interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
       Item: 
        Title: Supplementary materials
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
        Children: 
         Item: 
          Title: References
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
   Info: 
    Title: Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
    Author: Marta Lozano-Prieto
    Subject: EBioMedicine, 66 (2021) 103338. doi:10.1016/j.ebiom.2021.103338
    Keywords: "Spontaneous coronary artery dissection"; "microRNAs"; "Acute myocardial infarction"; "Biomarker"
    Creator: Elsevier
    Producer: Acrobat Distiller 10.0.0 (Windows)
    CreationDate: Wed Apr 14 23:05:54 CEST 2021
    ModDate: Wed Apr 14 15:36:26 CEST 2021
   ID: 0x705154c63582656c5c3a132175ba4a75, 0x634f5b84eae4d554919438e323110e2f
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 232
      ImageHeight: 299
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1430
      ImageHeight: 1009
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1872
      ImageHeight: 1360
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1716
      ImageHeight: 1512
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1232
      ImageHeight: 2207
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: AJLDDK+AdvPAC3D
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: AJLDDK+AdvPAC3D
       Flags: Nonsymbolic
       FontBBox: -166, -239, 989, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJLCKL+AdvOTf2586c63
      FontSubset: true
      FirstChar: 40
      LastChar: 237
      FontDescriptor: 
       FontName: AJLCKL+AdvOTf2586c63
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJLDNH+AdvTTb83ee1dd.B
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: AJLDNH+AdvTTb83ee1dd.B
       Flags: Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJMBNP+AdvP4C9543
      FontSubset: true
      FirstChar: 167
      LastChar: 167
      FontDescriptor: 
       FontName: AJMBNP+AdvP4C9543
       Flags: Nonsymbolic
       FontBBox: 0, -947, 1041, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJLCJJ+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: AJLCJJ+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: AJLCKM+AdvOTf2586c63+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: AJLCKM+AdvOTf2586c63+fb
       Flags: Symbolic
       FontBBox: -114, -208, 833, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AJLDOI+AdvOT5fa4e291+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: AJLDOI+AdvOT5fa4e291+20
       Flags: Nonsymbolic
       FontBBox: 19, -208, 947, 781
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJLDOJ+AdvP4A5FDB
      FontSubset: true
      FirstChar: 109
      LastChar: 109
      FontDescriptor: 
       FontName: AJLDOJ+AdvP4A5FDB
       Flags: Nonsymbolic
       FontBBox: 0, -239, 979, 718
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJKLNF+AdvOT5fa4e291
      FontSubset: true
      FirstChar: 35
      LastChar: 237
      FontDescriptor: 
       FontName: AJKLNF+AdvOT5fa4e291
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJLDPJ+AdvP4C9542
      FontSubset: true
      FirstChar: 60
      LastChar: 60
      FontDescriptor: 
       FontName: AJLDPJ+AdvP4C9542
       Flags: Nonsymbolic
       FontBBox: 0, -208, 979, 677
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AJLCLM+AdvOT5fa4e291+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: AJLCLM+AdvOT5fa4e291+fb
       Flags: Symbolic
       FontBBox: 40, 0, 572, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AJLCKK+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 122
      FontDescriptor: 
       FontName: AJLCKK+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2021-04-15T02:05:54+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2021-04-14T13:36:26-07:00</xmp:ModifyDate>
         <xmp:MetadataDate>2021-04-14T13:36:26-07:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 10.0.0 (Windows)</pdf:Producer>
         <pdf:Keywords>"Spontaneous coronary artery dissection"; "microRNAs"; "Acute myocardial infarction"; "Biomarker"</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.ebiom.2021.103338</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier B.V.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">EBioMedicine, 66 (2021) 103338. doi:10.1016/j.ebiom.2021.103338</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Spontaneous coronary artery dissection</rdf:li>
               <rdf:li>microRNAs</rdf:li>
               <rdf:li>Acute myocardial infarction</rdf:li>
               <rdf:li>Biomarker</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Marta Lozano-Prieto</rdf:li>
               <rdf:li>David Adlam</rdf:li>
               <rdf:li>Marcos García-Guimaraes</rdf:li>
               <rdf:li>Ancor Sanz-García</rdf:li>
               <rdf:li>Paula Vera-Tomé</rdf:li>
               <rdf:li>Fernando Rivero</rdf:li>
               <rdf:li>Javier Cuesta</rdf:li>
               <rdf:li>Teresa Bastante</rdf:li>
               <rdf:li>Anna A. Baranowska-Clarke</rdf:li>
               <rdf:li>Alicia Vara</rdf:li>
               <rdf:li>Enrique Martin-Gayo</rdf:li>
               <rdf:li>Miguel Vicente-Manzanares</rdf:li>
               <rdf:li>Pilar Martín</rdf:li>
               <rdf:li>Nilesh J Samani</rdf:li>
               <rdf:li>Francisco Sánchez-Madrid</rdf:li>
               <rdf:li>Fernando Alfonso</rdf:li>
               <rdf:li>Hortensia de la Fuente</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:0200085d-24dc-457f-8cbb-b40a2d93ef62</xmpMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:copyright>© 2021 The Authors. Published by Elsevier B.V.</prism:copyright>
         <prism:publicationName>EBioMedicine</prism:publicationName>
         <prism:issn>2352-3964</prism:issn>
         <prism:volume>66</prism:volume>
         <prism:doi>10.1016/j.ebiom.2021.103338</prism:doi>
         <prism:url>https://doi.org/10.1016/j.ebiom.2021.103338</prism:url>
         <prism:startingPage>103338</prism:startingPage>
         <prism:pageRange>103338</prism:pageRange>
         <prism:coverDisplayDate>April 2021</prism:coverDisplayDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1016/j.ebiom.2021.103338</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:AuthoritativeDomain>
            <rdf:Bag>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Bag>
         </pdfx:AuthoritativeDomain>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark_1_="http://crossref.org/crossmark/1.0/">
         <crossmark_1_:CrossmarkDomainExclusive>true</crossmark_1_:CrossmarkDomainExclusive>
         <crossmark_1_:MajorVersionDate>2010-04-23</crossmark_1_:MajorVersionDate>
         <crossmark_1_:DOI>10.1016/j.ebiom.2021.103338</crossmark_1_:DOI>
         <crossmark_1_:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </crossmark_1_:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 505, 601, 534, 629
      Annotation: 
       Subtype: Link
       Rect: 140, 577, 144, 587
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 146, 577, 151, 587
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 218, 577, 223, 587
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 225, 577, 230, 587
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 359, 577, 362, 587
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 364, 577, 369, 587
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 462, 577, 466, 587
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 124, 564, 128, 574
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 212, 564, 216, 574
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 282, 564, 286, 574
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 366, 564, 370, 574
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 175, 551, 179, 561
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 235, 551, 239, 561
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 346, 551, 350, 561
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 352, 551, 354, 561
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 177, 538, 181, 548
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 243, 538, 248, 548
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 250, 538, 252, 548
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 331, 538, 336, 548
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 467, 538, 471, 548
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 472, 538, 477, 548
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 479, 538, 481, 548
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 126, 525, 131, 535
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 133, 525, 135, 535
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 137, 526, 140, 532
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 253, 525, 257, 535
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 259, 525, 261, 535
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 263, 526, 266, 532
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 268, 520, 272, 531
       Destination: 356
      Annotation: 
       Subtype: Link
       Rect: 99, 100, 200, 106
      Annotation: 
       Subtype: Link
       Rect: 42, 66, 173, 72
      Annotation: 
       Subtype: Link
       Rect: 391, 57, 540, 63
      Annotation: 
       Subtype: Link
       Rect: 256, 749, 348, 755
      Annotation: 
       Subtype: Link
       Rect: 327, 721, 378, 729
      Annotation: 
       Subtype: Link
       Rect: 280, 666, 401, 674
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 377, 701, 550, 709
      Annotation: 
       Subtype: Link
       Rect: 156, 606, 166, 614
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 123, 554, 133, 562
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 140, 460, 148, 468
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 154, 460, 161, 468
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 66, 387, 76, 395
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 71, 313, 82, 321
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 91, 303, 101, 311
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 195, 272, 202, 279
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 209, 272, 221, 279
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 349, 546, 364, 554
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 304, 515, 309, 523
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 310, 515, 315, 523
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 304, 421, 309, 428
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 310, 421, 315, 428
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 317, 421, 326, 428
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 328, 421, 337, 428
       Destination: 107
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 232, 214, 246, 222
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 42, 68, 57, 76
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 449, 308, 543, 316
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 96, 612, 114, 619
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 115, 601, 142, 609
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 41, 591, 60, 599
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 259, 460, 279, 468
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 522, 706, 548, 714
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 497, 685, 524, 693
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 414, 580, 433, 588
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 375, 549, 395, 557
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 304, 455, 323, 463
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 427, 434, 446, 442
       Destination: 57
    Page: 
     Label: 5
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 155, 538, 283, 546
      Annotation: 
       Subtype: Link
       Rect: 32, 528, 69, 536
      Annotation: 
       Subtype: Link
       Rect: 352, 674, 372, 682
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 426, 643, 447, 651
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 361, 622, 381, 630
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 301, 601, 320, 609
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 477, 580, 496, 588
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 335, 507, 354, 515
       Destination: 72
    Page: 
     Label: 7
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 517, 65, 525
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 144, 465, 152, 473
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 158, 465, 170, 473
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 89, 392, 101, 400
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 107, 392, 119, 400
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 63, 340, 78, 347
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 57, 277, 72, 285
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 255, 224, 270, 232
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 225, 172, 234, 180
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 236, 172, 245, 180
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 384, 695, 399, 703
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 500, 643, 509, 651
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 511, 643, 520, 651
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 370, 622, 385, 630
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 304, 601, 313, 609
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 315, 601, 324, 609
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 358, 517, 373, 525
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 511, 496, 526, 504
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 468, 475, 483, 483
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 511, 465, 526, 473
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 453, 434, 462, 442
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 464, 434, 473, 442
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 475, 434, 484, 442
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 493, 371, 508, 379
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 537, 360, 552, 368
       Destination: 107
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 143, 423, 252, 430
      Annotation: 
       Subtype: Link
       Rect: 57, 383, 293, 389
      Annotation: 
       Subtype: Link
       Rect: 57, 375, 293, 381
      Annotation: 
       Subtype: Link
       Rect: 57, 367, 293, 373
      Annotation: 
       Subtype: Link
       Rect: 57, 359, 69, 365
      Annotation: 
       Subtype: Link
       Rect: 57, 351, 293, 357
      Annotation: 
       Subtype: Link
       Rect: 57, 343, 157, 349
      Annotation: 
       Subtype: Link
       Rect: 57, 335, 293, 341
      Annotation: 
       Subtype: Link
       Rect: 57, 327, 293, 333
      Annotation: 
       Subtype: Link
       Rect: 57, 319, 272, 325
      Annotation: 
       Subtype: Link
       Rect: 57, 311, 293, 317
      Annotation: 
       Subtype: Link
       Rect: 57, 303, 293, 309
      Annotation: 
       Subtype: Link
       Rect: 57, 295, 91, 302
      Annotation: 
       Subtype: Link
       Rect: 57, 287, 293, 294
      Annotation: 
       Subtype: Link
       Rect: 57, 279, 189, 286
      Annotation: 
       Subtype: Link
       Rect: 57, 271, 293, 278
      Annotation: 
       Subtype: Link
       Rect: 57, 263, 293, 270
      Annotation: 
       Subtype: Link
       Rect: 57, 255, 250, 262
      Annotation: 
       Subtype: Link
       Rect: 57, 247, 293, 254
      Annotation: 
       Subtype: Link
       Rect: 57, 239, 119, 246
      Annotation: 
       Subtype: Link
       Rect: 57, 231, 293, 238
      Annotation: 
       Subtype: Link
       Rect: 57, 223, 293, 230
      Annotation: 
       Subtype: Link
       Rect: 57, 215, 66, 222
      Annotation: 
       Subtype: Link
       Rect: 57, 207, 293, 214
      Annotation: 
       Subtype: Link
       Rect: 57, 199, 287, 206
      Annotation: 
       Subtype: Link
       Rect: 57, 191, 293, 198
      Annotation: 
       Subtype: Link
       Rect: 57, 184, 125, 190
      Annotation: 
       Subtype: Link
       Rect: 57, 176, 293, 182
      Annotation: 
       Subtype: Link
       Rect: 57, 168, 123, 174
      Annotation: 
       Subtype: Link
       Rect: 57, 160, 293, 166
      Annotation: 
       Subtype: Link
       Rect: 57, 152, 293, 158
      Annotation: 
       Subtype: Link
       Rect: 57, 144, 98, 150
      Annotation: 
       Subtype: Link
       Rect: 267, 120, 293, 126
      Annotation: 
       Subtype: Link
       Rect: 57, 112, 113, 118
      Annotation: 
       Subtype: Link
       Rect: 57, 104, 293, 110
      Annotation: 
       Subtype: Link
       Rect: 57, 96, 293, 102
      Annotation: 
       Subtype: Link
       Rect: 57, 88, 293, 94
      Annotation: 
       Subtype: Link
       Rect: 326, 727, 562, 733
      Annotation: 
       Subtype: Link
       Rect: 326, 719, 537, 725
      Annotation: 
       Subtype: Link
       Rect: 326, 711, 562, 717
      Annotation: 
       Subtype: Link
       Rect: 326, 703, 562, 709
      Annotation: 
       Subtype: Link
       Rect: 326, 695, 380, 701
      Annotation: 
       Subtype: Link
       Rect: 326, 687, 562, 693
      Annotation: 
       Subtype: Link
       Rect: 326, 679, 562, 686
      Annotation: 
       Subtype: Link
       Rect: 326, 671, 562, 678
      Annotation: 
       Subtype: Link
       Rect: 326, 663, 439, 670
      Annotation: 
       Subtype: Link
       Rect: 326, 655, 562, 662
      Annotation: 
       Subtype: Link
       Rect: 326, 647, 562, 654
      Annotation: 
       Subtype: Link
       Rect: 326, 639, 485, 646
      Annotation: 
       Subtype: Link
       Rect: 326, 631, 562, 638
      Annotation: 
       Subtype: Link
       Rect: 326, 623, 562, 630
      Annotation: 
       Subtype: Link
       Rect: 326, 615, 388, 622
      Annotation: 
       Subtype: Link
       Rect: 326, 607, 562, 614
      Annotation: 
       Subtype: Link
       Rect: 326, 599, 562, 606
      Annotation: 
       Subtype: Link
       Rect: 326, 591, 360, 598
      Annotation: 
       Subtype: Link
       Rect: 326, 583, 562, 590
      Annotation: 
       Subtype: Link
       Rect: 326, 576, 562, 582
      Annotation: 
       Subtype: Link
       Rect: 326, 568, 562, 574
      Annotation: 
       Subtype: Link
       Rect: 326, 560, 402, 566
      Annotation: 
       Subtype: Link
       Rect: 326, 552, 562, 558
      Annotation: 
       Subtype: Link
       Rect: 326, 544, 562, 550
      Annotation: 
       Subtype: Link
       Rect: 326, 536, 562, 542
      Annotation: 
       Subtype: Link
       Rect: 326, 528, 357, 534
      Annotation: 
       Subtype: Link
       Rect: 326, 520, 562, 526
      Annotation: 
       Subtype: Link
       Rect: 326, 512, 560, 518
      Annotation: 
       Subtype: Link
       Rect: 326, 504, 562, 510
      Annotation: 
       Subtype: Link
       Rect: 326, 496, 562, 502
      Annotation: 
       Subtype: Link
       Rect: 326, 488, 498, 494
      Annotation: 
       Subtype: Link
       Rect: 326, 480, 562, 486
      Annotation: 
       Subtype: Link
       Rect: 326, 472, 562, 478
      Annotation: 
       Subtype: Link
       Rect: 326, 464, 384, 470
      Annotation: 
       Subtype: Link
       Rect: 326, 456, 562, 462
      Annotation: 
       Subtype: Link
       Rect: 326, 448, 562, 454
      Annotation: 
       Subtype: Link
       Rect: 326, 440, 365, 446
      Annotation: 
       Subtype: Link
       Rect: 326, 432, 562, 438
      Annotation: 
       Subtype: Link
       Rect: 326, 424, 436, 430
      Annotation: 
       Subtype: Link
       Rect: 326, 416, 562, 422
      Annotation: 
       Subtype: Link
       Rect: 326, 408, 468, 415
      Annotation: 
       Subtype: Link
       Rect: 326, 400, 562, 407
      Annotation: 
       Subtype: Link
       Rect: 326, 392, 562, 399
      Annotation: 
       Subtype: Link
       Rect: 326, 384, 463, 391
      Annotation: 
       Subtype: Link
       Rect: 326, 376, 562, 383
      Annotation: 
       Subtype: Link
       Rect: 326, 368, 562, 375
      Annotation: 
       Subtype: Link
       Rect: 326, 360, 541, 367
      Annotation: 
       Subtype: Link
       Rect: 326, 352, 562, 359
      Annotation: 
       Subtype: Link
       Rect: 326, 344, 562, 351
      Annotation: 
       Subtype: Link
       Rect: 326, 336, 489, 343
      Annotation: 
       Subtype: Link
       Rect: 326, 328, 562, 335
      Annotation: 
       Subtype: Link
       Rect: 326, 320, 562, 327
      Annotation: 
       Subtype: Link
       Rect: 326, 313, 562, 319
      Annotation: 
       Subtype: Link
       Rect: 326, 305, 425, 311
      Annotation: 
       Subtype: Link
       Rect: 326, 297, 562, 303
      Annotation: 
       Subtype: Link
       Rect: 326, 289, 562, 295
      Annotation: 
       Subtype: Link
       Rect: 326, 281, 388, 287
      Annotation: 
       Subtype: Link
       Rect: 326, 273, 562, 279
      Annotation: 
       Subtype: Link
       Rect: 326, 265, 562, 271
      Annotation: 
       Subtype: Link
       Rect: 326, 257, 427, 263
      Annotation: 
       Subtype: Link
       Rect: 326, 249, 562, 255
      Annotation: 
       Subtype: Link
       Rect: 326, 241, 522, 247
      Annotation: 
       Subtype: Link
       Rect: 326, 233, 562, 239
      Annotation: 
       Subtype: Link
       Rect: 326, 225, 434, 231
      Annotation: 
       Subtype: Link
       Rect: 326, 217, 562, 223
      Annotation: 
       Subtype: Link
       Rect: 326, 209, 562, 215
      Annotation: 
       Subtype: Link
       Rect: 326, 201, 427, 207
      Annotation: 
       Subtype: Link
       Rect: 326, 193, 562, 199
      Annotation: 
       Subtype: Link
       Rect: 326, 185, 562, 191
      Annotation: 
       Subtype: Link
       Rect: 326, 177, 450, 183
      Annotation: 
       Subtype: Link
       Rect: 326, 169, 562, 175
      Annotation: 
       Subtype: Link
       Rect: 326, 161, 411, 167
      Annotation: 
       Subtype: Link
       Rect: 326, 153, 562, 159
      Annotation: 
       Subtype: Link
       Rect: 326, 145, 562, 152
      Annotation: 
       Subtype: Link
       Rect: 326, 137, 508, 144
      Annotation: 
       Subtype: Link
       Rect: 326, 129, 562, 136
      Annotation: 
       Subtype: Link
       Rect: 326, 121, 562, 128
      Annotation: 
       Subtype: Link
       Rect: 326, 113, 357, 120
      Annotation: 
       Subtype: Link
       Rect: 326, 105, 562, 112
      Annotation: 
       Subtype: Link
       Rect: 326, 97, 562, 104
      Annotation: 
       Subtype: Link
       Rect: 326, 89, 533, 96
  Checksum: da7f51f8
   Type: CRC32
  Checksum: 51d760459fc9f951621f1991a460ffcc
   Type: MD5
  Checksum: d47e7c6b04ce095f0050d2b9e150d7a1b5a94aa3
   Type: SHA-1