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Med. Chem. American Chemical Society Maria Gallo (ORCID: 0000-0001-9099-7235) Estefanía Moreno (ORCID: 0000-0002-2491-5753) Sira Defaus (ORCID: 0000-0002-3106-458X) Antonio Ortega-Alvaro Angel Gonzalez Patricia Robledo Marco Cavaco (ORCID: 0000-0002-0938-9038) Vera Neves (ORCID: 0000-0002-2989-7208) Miguel A. R. B. Castanho (ORCID: 0000-0001-7891-7562) Vicent Casadó (ORCID: 0000-0002-1764-3825) Leonardo Pardo Rafael Maldonado David Andreu (ORCID: 0000-0002-6317-6666) application/pdf research-article http://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.1c00484 © 2021 American Chemical Society - License: © 2021 American Chemical Society American Chemical Society True © 2021 American Chemical Society - License: © 2021 American Chemical Society © 2021 American Chemical Society - License: © 2021 American Chemical Society Issue 10.1021/acs.jmedchem.1c00484 VoR 04/23/2021 64 10 6937 6948 © 2021 American Chemical Society article 0022-2623 1520-4804 Journal of Medicinal Chemistry research-article Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 60, 644, 121, 657 Annotation: Subtype: Link Rect: 121, 644, 213, 657 Annotation: Subtype: Link Rect: 213, 644, 276, 657 Annotation: Subtype: Link Rect: 276, 644, 394, 657 Annotation: Subtype: Link Rect: 394, 644, 477, 657 Annotation: Subtype: Link 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