24d028c4d09ed01be7845eb9b414369d pmc_33917093.pdf 99d8c004d2e87a70e6c0ed6311392bff315646e7 pmc_33917093.pdf 3df7c22375a4432e9ab6497286d769f092999fbe61b72bdb74eb6d68484474f2 pmc_33917093.pdf Title: Use of Anti-Cytokine Therapy in Kidney Transplant Recipients with COVID-19 Subject: In the context of the coronavirus disease 2019 (COVID-19) pandemic, we aimed to evaluate the impact of anti-cytokine therapies (AT) in kidney transplant recipients requiring hospitalization due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This is an observational retrospective study, which included patients from March to May 2020. An inverse probability of treatment weighting from a propensity score to receive AT was used in all statistical analyses, and we applied a bootstrap procedure in order to calculate an estimation of the 2.5th and 97.5th percentiles of odds ratio (OR). outcomes were measured using an ordinal scale determination (OSD). A total of 33 kidney recipients required hospitalization and 54% of them received at least one AT, mainly tocilizumab (42%), followed by anakinra (12%). There was no statistical effect in terms of intensive care unit (ICU) admission, respiratory secondary infections (35% vs. 7%) or mortality (16% vs. 13%) comparing patients that received AT with those who did not. Nevertheless, patients who received AT presented better outcomes during hospitalization in terms of OSD 5 ((OR 0.31; 2.5th, 97.5th percentiles (0.10; 0.72)). These analyses indicate, as a plausible hypothesis, that the use of AT in kidney transplant recipients presenting with COVID-19 could be beneficial, even though multicenter randomized control trials using these therapies in transplanted patients are needed. Keywords: COVID-19; kidney transplantation; anti-cytokine therapy; mortality; infection Author: Marta Bodro, Frederic Cofan, Jose Ríos, Sabina Herrera, Laura Linares, María Angeles Marcos, Alex Soriano, Asunción Moreno and Fritz Diekmann Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Apr 7 12:55:17 2021 CEST ModDate: Fri Apr 9 06:05:49 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 427355 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FGUDRR+VnURWPalladioL Type 1 Custom yes yes no 10 0 WRFJAC+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 YCLOAO+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 JFXMEY+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 KOSUXD+CMSY10 Type 1 Builtin yes yes no 28 0 GOCQIR+EURM10 Type 1 Builtin yes yes no 32 0 YWWVQQ+VnURWPalladioL-Bold Type 1 Custom yes yes no 36 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 44 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 47 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 69 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 73 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 77 0 MLYEVU+MSAM10 Type 1 Builtin yes yes no 95 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 99 0 CFMOJL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 115 0 CFMOJM+PalatinoLinotype CID TrueType Identity-H yes yes yes 118 0 CFMOJN+PalatinoLinotype TrueType WinAnsi yes yes no 124 0 CFMOKP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 127 0 CFMPBN+TimesNewRoman CID TrueType Identity-H yes yes yes 130 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:26:49 CEST RepresentationInformation: pmc_33917093.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-05-03 03:50:26 CEST Size: 427355 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 256 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Management of Coronavirus Disease 2019 (COVID-19) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Management of Immunosuppressive Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Ordinary Scale Determination (OSD) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Use of Anti-Cytokine Therapy in Kidney Transplant Recipients with COVID-19 Author: Marta Bodro, Frederic Cofan, Jose Ríos, Sabina Herrera, Laura Linares, María Angeles Marcos, Alex Soriano, Asunción Moreno and Fritz Diekmann Subject: In the context of the coronavirus disease 2019 (COVID-19) pandemic, we aimed to evaluate the impact of anti-cytokine therapies (AT) in kidney transplant recipients requiring hospitalization due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This is an observational retrospective study, which included patients from March to May 2020. An inverse probability of treatment weighting from a propensity score to receive AT was used in all statistical analyses, and we applied a bootstrap procedure in order to calculate an estimation of the 2.5th and 97.5th percentiles of odds ratio (OR). outcomes were measured using an ordinal scale determination (OSD). A total of 33 kidney recipients required hospitalization and 54% of them received at least one AT, mainly tocilizumab (42%), followed by anakinra (12%). There was no statistical effect in terms of intensive care unit (ICU) admission, respiratory secondary infections (35% vs. 7%) or mortality (16% vs. 13%) comparing patients that received AT with those who did not. Nevertheless, patients who received AT presented better outcomes during hospitalization in terms of OSD 5 ((OR 0.31; 2.5th, 97.5th percentiles (0.10; 0.72)). These analyses indicate, as a plausible hypothesis, that the use of AT in kidney transplant recipients presenting with COVID-19 could be beneficial, even though multicenter randomized control trials using these therapies in transplanted patients are needed. Keywords: COVID-19; kidney transplantation; anti-cytokine therapy; mortality; infection Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Apr 07 12:55:17 CEST 2021 ModDate: Fri Apr 09 06:05:49 CEST 2021 ID: 0x3c557366250ab5f145435a59c522c276, 0x3c557366250ab5f145435a59c522c276 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: GOCQIR+EURM10 FontSubset: true FirstChar: 11 LastChar: 13 FontDescriptor: FontName: GOCQIR+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: QLBIEB+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: QLBIEB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YCLOAO+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: YCLOAO+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YWWVQQ+VnURWPalladioL-Bold FontSubset: true FirstChar: 189 LastChar: 226 FontDescriptor: FontName: YWWVQQ+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JFXMEY+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 237 FontDescriptor: FontName: JFXMEY+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FGUDRR+VnURWPalladioL FontSubset: true FirstChar: 145 LastChar: 226 FontDescriptor: FontName: FGUDRR+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: KOSUXD+CMSY10 FontSubset: true FirstChar: 0 LastChar: 21 FontDescriptor: FontName: KOSUXD+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: WRFJAC+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: WRFJAC+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MLYEVU+MSAM10 FontSubset: true FirstChar: 4 LastChar: 4 FontDescriptor: FontName: MLYEVU+MSAM10 Flags: Symbolic FontBBox: 8, -463, 1331, 1003 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 35, 759, 176, 795 Annotation: Subtype: Link Rect: 515, 759, 560, 795 Annotation: Subtype: Link Rect: 100, 650, 111, 663 Annotation: Subtype: Link Rect: 121, 346, 154, 355 Annotation: Subtype: Link Rect: 35, 334, 129, 343 Annotation: Subtype: Link Rect: 35, 162, 97, 184 Annotation: Subtype: Link Rect: 153, 89, 154, 98 Annotation: Subtype: Link Rect: 35, 77, 147, 86 Annotation: Subtype: Link Rect: 491, 168, 498, 177 ActionDest: 136 Annotation: Subtype: Link Rect: 492, 118, 499, 127 ActionDest: 136 Annotation: Subtype: Link Rect: 502, 118, 509, 127 ActionDest: 136 Annotation: Subtype: Link Rect: 289, 93, 296, 102 ActionDest: 136 Annotation: Subtype: Link Rect: 541, 67, 548, 76 ActionDest: 136 Annotation: Subtype: Link Rect: 549, 67, 556, 76 ActionDest: 136 Annotation: Subtype: Link Rect: 131, 17, 268, 28 Annotation: Subtype: Link Rect: 422, 17, 558, 28 Annotation: Subtype: Link Rect: 35, 435, 87, 454 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 275, 724, 282, 733 ActionDest: 136 Annotation: Subtype: Link Rect: 257, 711, 264, 721 ActionDest: 136 Annotation: Subtype: Link Rect: 291, 686, 298, 695 ActionDest: 136 Annotation: Subtype: Link Rect: 301, 686, 313, 695 ActionDest: 139 Annotation: Subtype: Link Rect: 450, 209, 462, 218 ActionDest: 139 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 387, 458, 399, 467 ActionDest: 139 Annotation: Subtype: Link Rect: 421, 332, 433, 342 ActionDest: 139 Annotation: Subtype: Link Rect: 217, 219, 229, 229 ActionDest: 139 Annotation: Subtype: Link Rect: 248, 66, 255, 78 ActionDest: 92 Page: Sequence: 4 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 213, 732, 220, 744 ActionDest: 106 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 363, 335, 370, 347 ActionDest: 106 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 230, 644, 242, 653 ActionDest: 139 Annotation: Subtype: Link Rect: 278, 606, 285, 615 ActionDest: 136 Annotation: Subtype: Link Rect: 454, 594, 466, 603 ActionDest: 139 Annotation: Subtype: Link Rect: 469, 594, 481, 603 ActionDest: 139 Annotation: Subtype: Link Rect: 331, 543, 343, 553 ActionDest: 139 Annotation: Subtype: Link Rect: 426, 468, 438, 477 ActionDest: 139 Annotation: Subtype: Link Rect: 452, 443, 464, 452 ActionDest: 139 Annotation: Subtype: Link Rect: 240, 405, 252, 414 ActionDest: 139 Annotation: Subtype: Link Rect: 531, 393, 543, 402 ActionDest: 139 Annotation: Subtype: Link Rect: 543, 393, 555, 402 ActionDest: 139 Annotation: Subtype: Link Rect: 448, 380, 460, 389 ActionDest: 139 Annotation: Subtype: Link Rect: 321, 355, 333, 364 ActionDest: 139 Annotation: Subtype: Link Rect: 288, 317, 300, 327 ActionDest: 139 Annotation: Subtype: Link Rect: 380, 305, 392, 314 ActionDest: 139 Annotation: Subtype: Link Rect: 423, 292, 435, 301 ActionDest: 139 Annotation: Subtype: Link Rect: 438, 292, 450, 301 ActionDest: 139 Annotation: Subtype: Link Rect: 458, 255, 470, 264 ActionDest: 142 Annotation: Subtype: Link Rect: 247, 230, 259, 239 ActionDest: 142 Annotation: Subtype: Link Rect: 250, 205, 262, 214 ActionDest: 142 Annotation: Subtype: Link Rect: 518, 205, 524, 214 ActionDest: 136 Annotation: Subtype: Link Rect: 525, 205, 532, 214 ActionDest: 139 Annotation: Subtype: Link Rect: 320, 167, 332, 176 ActionDest: 139 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 345, 622, 357, 631 ActionDest: 142 Annotation: Subtype: Link Rect: 360, 622, 372, 631 ActionDest: 142 Annotation: Subtype: Link Rect: 536, 278, 560, 289 Annotation: Subtype: Link Rect: 56, 266, 560, 277 Annotation: Subtype: Link Rect: 200, 232, 238, 243 Annotation: Subtype: Link Rect: 349, 209, 386, 220 Annotation: Subtype: Link Rect: 351, 186, 389, 197 Annotation: Subtype: Link Rect: 275, 163, 313, 174 Annotation: Subtype: Link Rect: 265, 140, 302, 151 Annotation: Subtype: Link Rect: 140, 106, 178, 116 Annotation: Subtype: Link Rect: 184, 106, 220, 116 Annotation: Subtype: Link Rect: 140, 71, 178, 81 Annotation: Subtype: Link Rect: 184, 71, 220, 81 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 312, 709, 350, 720 Annotation: Subtype: Link Rect: 356, 709, 392, 720 Annotation: Subtype: Link Rect: 234, 675, 271, 686 Annotation: Subtype: Link Rect: 210, 640, 247, 651 Annotation: Subtype: Link Rect: 253, 640, 289, 651 Annotation: Subtype: Link Rect: 362, 617, 400, 628 Annotation: Subtype: Link Rect: 406, 617, 442, 628 Annotation: Subtype: Link Rect: 279, 583, 316, 594 Annotation: Subtype: Link Rect: 323, 583, 359, 594 Annotation: Subtype: Link Rect: 213, 561, 251, 571 Annotation: Subtype: Link Rect: 257, 561, 293, 571 Annotation: Subtype: Link Rect: 278, 537, 316, 548 Annotation: Subtype: Link Rect: 516, 491, 553, 502 Annotation: Subtype: Link Rect: 458, 479, 495, 490 Annotation: Subtype: Link Rect: 440, 456, 477, 467 Annotation: Subtype: Link Rect: 430, 445, 468, 456 Annotation: Subtype: Link Rect: 140, 423, 178, 433 Annotation: Subtype: Link Rect: 122, 400, 160, 410 Annotation: Subtype: Link Rect: 508, 364, 545, 375 Annotation: Subtype: Link Rect: 127, 330, 312, 341 Annotation: Subtype: Link Rect: 447, 307, 485, 318 Annotation: Subtype: Link Rect: 125, 272, 310, 283 Annotation: Subtype: Link Rect: 430, 272, 467, 283 Annotation: Subtype: Link Rect: 399, 238, 437, 249 Annotation: Subtype: Link Rect: 167, 204, 205, 214 Annotation: Subtype: Link Rect: 315, 169, 353, 180 Annotation: Subtype: Link Rect: 500, 146, 538, 157 Annotation: Subtype: Link Rect: 253, 123, 290, 134 Annotation: Subtype: Link Rect: 196, 88, 233, 99 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 416, 709, 454, 720 Annotation: Subtype: Link Rect: 270, 686, 308, 697 Annotation: Subtype: Link Rect: 282, 652, 319, 663 Annotation: Subtype: Link Rect: 280, 618, 318, 628 Annotation: Subtype: Link Rect: 470, 583, 508, 594 Checksum: 02a7e2c6 Type: CRC32 Checksum: 24d028c4d09ed01be7845eb9b414369d Type: MD5 Checksum: 99d8c004d2e87a70e6c0ed6311392bff315646e7 Type: SHA-1