33646fdbfad4812a20b04b181bf6cf6f pmc_33917523.pdf 624081349c7511d9a07663e8d19945c9a1061958 pmc_33917523.pdf 1c8d0b67bf1fc57fe74ad4dadf3bfb62f8e3f457e1f899724d4cbc17880aafd5 pmc_33917523.pdf Title: Clinical Characteristics and Degree of Glycemic and Cardiovascular Risk Factor Control in Patients with Type 1 Diabetes in Catalonia (Spain) Subject: Background: This study aims to evaluate the clinical characteristics, complications, degree of glycemic control, and cardiovascular risk factor control in patients with type 1 diabetes in Catalonia (Northwest of Spain). Methods: Cross-sectional study using a database including clinical, laboratory, and treatment data. Patients with an ICD10 diagnosis of type 1 diabetes were included, excluding those treated with glucose-lowering agents other than insulin, or treated only with basal insulin two years after diagnosis. Results: 15,008 patients were analysed. Median IQR age was 42 (31–53) years, diabetes duration 11.8 (6.8–16.0) years, 56.5% men. Median (IQR) HbA1c was 7.9% (7.1–8.8). Microvascular complications were present in 24.4% of patients, 43.6% in those with a diabetes duration >19 years. In presence of known cardiovascular disease 69.3% of patients showed an LDL-C concentration >70 mg/dL, 37% had a systolic blood pressure >135 mmHg and 22.4% were smokers. Conclusions: This study provides a reliable snapshot about the clinical situation of a large population of patients with T1D in Catalonia, which is similar to that of other western areas. The lack of adequate control of cardiovascular risk factors in a significant proportion of patients with cardiovascular disease deserves a more detailed analysis and urges the need for improvement strategies. Keywords: type-1 diabetes; cardiovascular risk factors; glucose control; complications Author: Gabriel Gimenez-Perez, Josep Franch-Nadal, Emilio Ortega, Manel Mata-Cases, Albert Goday, Jordi Real, Angel Rodriguez, Bogdan Vlacho and Dídac Mauricio Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Apr 7 10:55:01 2021 CEST ModDate: Fri Apr 9 06:00:41 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 749811 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KORLVE+VnURWPalladioL Type 1 Custom yes yes no 10 0 SRZOML+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 KHLHJR+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 QBXQHT+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 87 0 PDTLUH+CMSY10 Type 1 Builtin yes yes no 91 0 IMPOAJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 109 0 IMPOAK+PalatinoLinotype CID TrueType Identity-H yes yes yes 112 0 IMPOAL+PalatinoLinotype TrueType WinAnsi yes yes no 118 0 IMPOBN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 121 0 IMPOAJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 139 0 IMPOAL+PalatinoLinotype TrueType WinAnsi yes yes no 142 0 IMPOBN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 145 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 158 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:20:59 CEST RepresentationInformation: pmc_33917523.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:46 CEST Size: 749811 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 320 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: Glucose Control and Diabetes-Related Complications Destination: subsection.3.1 Item: Title: Control of Cardiovascular Risk-Factors Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Clinical Characteristics and Degree of Glycemic and Cardiovascular Risk Factor Control in Patients with Type 1 Diabetes in Catalonia (Spain) Author: Gabriel Gimenez-Perez, Josep Franch-Nadal, Emilio Ortega, Manel Mata-Cases, Albert Goday, Jordi Real, Angel Rodriguez, Bogdan Vlacho and Dídac Mauricio Subject: Background: This study aims to evaluate the clinical characteristics, complications, degree of glycemic control, and cardiovascular risk factor control in patients with type 1 diabetes in Catalonia (Northwest of Spain). Methods: Cross-sectional study using a database including clinical, laboratory, and treatment data. Patients with an ICD10 diagnosis of type 1 diabetes were included, excluding those treated with glucose-lowering agents other than insulin, or treated only with basal insulin two years after diagnosis. Results: 15,008 patients were analysed. Median IQR age was 42 (31 53) years, diabetes duration 11.8 (6.8 16.0) years, 56.5% men. Median (IQR) HbA1c was 7.9% (7.1 8.8). Microvascular complications were present in 24.4% of patients, 43.6% in those with a diabetes duration >19 years. In presence of known cardiovascular disease 69.3% of patients showed an LDL-C concentration >70 mg/dL, 37% had a systolic blood pressure >135 mmHg and 22.4% were smokers. Conclusions: This study provides a reliable snapshot about the clinical situation of a large population of patients with T1D in Catalonia, which is similar to that of other western areas. The lack of adequate control of cardiovascular risk factors in a significant proportion of patients with cardiovascular disease deserves a more detailed analysis and urges the need for improvement strategies. 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