b22fbca5b1ac59727115a86b8c11af7d pmc_33919434.pdf b66960cf033732a1a2feeb20abe2212bf906da10 pmc_33919434.pdf 0d97a0bfd013c17bcf8e61eab2a53a103227ab3f65f5fae5ea67c9862a32ace8 pmc_33919434.pdf Title: Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease Subject: Unmet needs in the treatment of psoriasis call for novel therapeutic strategies. Pustular psoriasis and psoriatic arthritis often represent a therapeutic challenge. Focus on IL-36 cytokines offers an interesting approach, as the IL-36 axis has been appointed a critical driver of the autoinflammatory responses involved in pustular psoriasis. Two IL-36R blocking antibodies, imsidolimab and spesolimab, are currently undergoing phase II and III clinical trials, with promising results. Keywords: psoriasis; pustular psoriasis; psoriatic arthritis; imsidolimab; spesolimab; IL-36; IL-36R; pathogenesis Author: Helena Iznardo and Lluís Puig Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon May 10 09:25:07 2021 CEST ModDate: Mon May 10 09:29:43 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1037080 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LNTTSH+VnURWPalladioL Type 1 Custom yes yes no 10 0 ZBZWDY+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 LOSCUG+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 XWOWYZ+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 36 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 ASHNOE+EURM10 Type 1 Builtin yes yes no 81 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 93 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 97 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 101 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 105 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 121 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 125 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 129 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 133 0 SymbolMT CID TrueType Identity-H yes no yes 140 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:20:44 CEST RepresentationInformation: pmc_33919434.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:47 CEST Size: 1037080 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 358 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: The Role of IL-36 Family Cytokines in Psoriasis Pathogenesis Destination: section.2 Item: Title: Targeting IL-36R in Psoriasis Destination: section.3 Item: Title: Conclusions Destination: section.4 Item: Title: References Destination: section.4 Info: Title: Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease Author: Helena Iznardo and Lluís Puig Subject: Unmet needs in the treatment of psoriasis call for novel therapeutic strategies. Pustular psoriasis and psoriatic arthritis often represent a therapeutic challenge. Focus on IL-36 cytokines offers an interesting approach, as the IL-36 axis has been appointed a critical driver of the autoinflammatory responses involved in pustular psoriasis. Two IL-36R blocking antibodies, imsidolimab and spesolimab, are currently undergoing phase II and III clinical trials, with promising results. 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