135ac8f8be2eecb8f50369271d41c81c pmc_33920619.pdf b5e55e3b137532694b91adcd3714268644ede948 pmc_33920619.pdf 44353cdd31d43cb8e1da707349cd71f9c6731ce3078650f448778065b63465a9 pmc_33920619.pdf Title: Candida Periprosthetic Joint Infection: Is It Curable? Subject: Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable. Keywords: Candida spp.; periprosthetic joint infection; fungus; biofilm; antifungal-loaded cement spacer; two-stage exchange surgery Author: Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Pablo S. 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Author: Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Pablo S. Corona and Carles Pigrau Subject: Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable. 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