4e176b71ff5b67fec0f54d67c7b779e6 pmc_33924825.pdf 85d1d96d216c98a5b912ec3414c63ff652b6d386 pmc_33924825.pdf 7a3ae1a9d822d28e008db54014cb70ce35215e2601bed90f808a834c615d78da pmc_33924825.pdf Title: A Peculiar Distribution of the Emerging Nematode Angiostrongylus cantonensis in the Canary Islands (Spain): Recent Introduction or Isolation Effect? Subject: Angiostrongylus cantonensis is an emerging zoonotic nematode recognized as the leading cause of eosinophilic meningitis in the word. After its discovery in China, it was recorded in 30 countries worldwide. Recently, it has expanded to new areas such as South America and it has been recently found in the Atlantic island of Tenerife (Canary Islands). In order to characterize the distribution of A. cantonensis in the Canary Islands, the lungs of 1462 rodents were sampled in eight islands of the archipelago over 13 years and were then analyzed for A. cantonensis. Remarkably, the parasite was detected only in Tenerife, in Rattus rattus (19.7%) and Rattus norvegicus (7.14%). They were concretely in the northern part of the island, which had a warmer and more humid climate than the south and main cities. The absence of this nematode in other islands with similar environmental conditions could be explained by an isolation effect or by a recent introduction of the parasite in the islands. Besides, the presence in Tenerife of the most invasive lineage of A. cantonensis reinforced the hypothesis of a recent introduction on this island. This study highlights the need to implement control measures to prevent the expansion to other areas in order to avoid the transmission to humans and other animals. Keywords: Angiostrongylus cantonensis; Canary Islands; emerging disease; rat lungworm; Rattus; expanding parasite; eosinophilic meningitis Author: Natalia Martín-Carrillo, Carlos Feliu, Néstor Abreu-Acosta, Elena Izquierdo-Rodriguez, Roberto Dorta-Guerra, Jordi Miquel, Estefanía Abreu-Yanes, Aarón Martin-Alonso, Katherine García-Livia, María Antonieta Quispe-Ricalde, Jordi Serra-Cobo, Basilio Valladares and Pilar Foronda Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Apr 28 08:33:28 2021 CEST ModDate: Wed Apr 28 08:39:23 2021 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1342393 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XMZKYG+URWPalladioL-Ital Type 1 Custom yes yes no 10 0 WFXNIG+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 QXKDYL+URWPalladioL-BoldItal Type 1 Custom yes yes no 19 0 PRGTDR+URWPalladioL-Roma Type 1 Custom yes yes no 23 0 XWOCXD+VnURWPalladioL-Bold Type 1 Custom yes yes no 27 0 WGFAOR+VnURWPalladioL Type 1 Custom yes yes no 32 0 SZMRXJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 62 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 66 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 70 0 FVHZNK+CMSY10 Type 1 Builtin yes yes no 85 0 HDPAKM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 96 0 HDPAKN+PalatinoLinotype CID TrueType Identity-H yes yes yes 99 0 HDPAKO+PalatinoLinotype TrueType WinAnsi yes yes no 105 0 HDPALA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 108 0 HDPAKM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 122 0 HDPAKO+PalatinoLinotype TrueType WinAnsi yes yes no 125 0 HDPALA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 128 0 HDPAKM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 145 0 HDPAKO+PalatinoLinotype TrueType WinAnsi yes yes no 148 0 HDPALA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 151 0 HDPBIM+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 154 0 GEJNTL+VnURWPalladioL-Italic Type 1 Custom yes yes no 173 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 03:19:47 CEST RepresentationInformation: pmc_33924825.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 12:09:52 CEST Size: 1342393 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 312 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: A Peculiar Distribution of the Emerging Nematode Angiostrongylus cantonensis in the Canary Islands (Spain): Recent Introduction or Isolation Effect? Author: Natalia Martín-Carrillo, Carlos Feliu, Néstor Abreu-Acosta, Elena Izquierdo-Rodriguez, Roberto Dorta-Guerra, Jordi Miquel, Estefanía Abreu-Yanes, Aarón Martin-Alonso, Katherine García-Livia, María Antonieta Quispe-Ricalde, Jordi Serra-Cobo, Basilio Valladares and Pilar Foronda Subject: Angiostrongylus cantonensis is an emerging zoonotic nematode recognized as the leading cause of eosinophilic meningitis in the word. After its discovery in China, it was recorded in 30 countries worldwide. Recently, it has expanded to new areas such as South America and it has been recently found in the Atlantic island of Tenerife (Canary Islands). In order to characterize the distribution of A. cantonensis in the Canary Islands, the lungs of 1462 rodents were sampled in eight islands of the archipelago over 13 years and were then analyzed for A. cantonensis. Remarkably, the parasite was detected only in Tenerife, in Rattus rattus (19.7%) and Rattus norvegicus (7.14%). They were concretely in the northern part of the island, which had a warmer and more humid climate than the south and main cities. The absence of this nematode in other islands with similar environmental conditions could be explained by an isolation effect or by a recent introduction of the parasite in the islands. Besides, the presence in Tenerife of the most invasive lineage of A. cantonensis reinforced the hypothesis of a recent introduction on this island. This study highlights the need to implement control measures to prevent the expansion to other areas in order to avoid the transmission to humans and other animals. 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