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PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging Destination: atl_HBM_25350_ Children: Item: Title: 1 INTRODUCTION Destination: HeadingHBM_25350hbm25350-sec-0001 Item: Title: 2 MATERIALS AND METHODS Destination: HeadingHBM_25350hbm25350-sec-0002 Children: Item: Title: 2.1 Participants Destination: HeadingHBM_25350hbm25350-sec-0003 Item: Title: 2.2 MRI acquisition Destination: HeadingHBM_25350hbm25350-sec-0004 Item: Title: 2.3 PET acquisition Destination: HeadingHBM_25350hbm25350-sec-0005 Item: Title: 2.4 MRI image processing Destination: HeadingHBM_25350hbm25350-sec-0006 Item: Title: 2.5 PET image processing Destination: HeadingHBM_25350hbm25350-sec-0007 Item: Title: 2.6 Group averaged FBP-SUVR and tau-SUVR Destination: HeadingHBM_25350hbm25350-sec-0008 Item: Title: 2.7 Graph theory-based PET correlation within single PET modality and between PET modalities Destination: HeadingHBM_25350hbm25350-sec-0009 Children: Item: Title: 2.7.1 Partial PET correlation within single PET modality Destination: HeadingHBM_25350hbm25350-sec-0010 Item: Title: 2.7.2 Partial PET correlation between different PET modalities Destination: HeadingHBM_25350hbm25350-sec-0011 Item: Title: 2.7.3 Weighted degree of the correlation matrix Destination: HeadingHBM_25350hbm25350-sec-0012 Item: Title: 2.8 Relationship between the information of the graph theory-based correlation matrix and cognitive variability Destination: HeadingHBM_25350hbm25350-sec-0013 Children: Item: Title: 2.8.1 Measurement of averaged PET-SUVR Destination: HeadingHBM_25350hbm25350-sec-0014 Item: Title: 2.8.2 Partial correlation between the averaged PET-SUVRs and cognitive scores Destination: HeadingHBM_25350hbm25350-sec-0015 Item: Title: 2.8.3 Measurement of centroid of cognition-related PET uptakes Destination: HeadingHBM_25350hbm25350-sec-0016 Item: Title: 2.9 Longitudinal analysis Destination: HeadingHBM_25350hbm25350-sec-0017 Children: Item: Title: 2.9.1 Measurement of similarity score Destination: HeadingHBM_25350hbm25350-sec-0018 Item: Title: 2.9.2 Linear association between the similarity scores and cognitive scores Destination: HeadingHBM_25350hbm25350-sec-0019 Item: Title: 3 RESULTS Destination: HeadingHBM_25350hbm25350-sec-0020 Children: Item: Title: 3.1 Group demographics and clinical characteristics Destination: HeadingHBM_25350hbm25350-sec-0021 Item: Title: 3.2 Group averaged FBP-SUVR and tau-SUVR Destination: HeadingHBM_25350hbm25350-sec-0022 Item: Title: 3.3 Graph theory-based PET correlation within single PET modality and between different PET modalities Destination: HeadingHBM_25350hbm25350-sec-0023 Item: Title: 3.4 Relationship between the information of the graph theory-based correlation matrix and cognitive variability Destination: HeadingHBM_25350hbm25350-sec-0024 Item: Title: 3.5 Measurement of cognition-related PET uptakes at baseline and longitudinal FU Destination: HeadingHBM_25350hbm25350-sec-0025 Item: Title: 4 DISCUSSION Destination: HeadingHBM_25350hbm25350-sec-0026 Item: Title: 5 CONCLUSION Destination: HeadingHBM_25350hbm25350-sec-0027 Item: Title: ACKNOWLEDGMENT Destination: HeadingHBM_25350hbm25350-sec-0028 Item: Title: CONFLICT OF INTEREST Destination: HeadingHBM_25350hbm25350-sec-0029 Item: Title: AUTHOR CONTRIBUTIONS Destination: HeadingHBM_25350hbm25350-sec-0030 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: HeadingHBM_25350hbm25350-sec-0032 Item: Title: REFERENCES Destination: HeadingHBM_25350hbm25350-bibl-00011 Info: Title: Network Interdigitations of Tau and Amyloid-beta Deposits Define Cognitive Levels in Aging Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 11.0 (Windows) CreationDate: Thu Jun 03 15:33:21 CEST 2021 ModDate: Thu Jun 03 15:33:21 CEST 2021 ID: 0x3316aaee8eff66e77fcd1d708b8978f1, 0x17af77a5bcd7018fd73dc859525c7293 Filters: FilterPipeline: 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