d8558beccb4156f18d3040b2a20b617c pmc_33986423.pdf a4799bb2676ab1930cd468372f110fe07c907ac0 pmc_33986423.pdf 8f08e5d3fde910a7ea3d9d8c7b67e3696c6ec44a053c28297592a3e59e867a8c pmc_33986423.pdf Title: NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-89749-5 Author: Constance Delaby Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri May 7 22:55:15 2021 CEST ModDate: Sat May 8 08:13:00 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 818045 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FIQKUT+Wingdings-Regular Type 1C WinAnsi yes yes yes 307 0 MinionPro-Regular Type 1C Custom yes no yes 64 0 LCWAXW+Corbel-Bold CID TrueType Identity-H yes yes yes 67 0 Corbel2 TrueType WinAnsi yes no yes 68 0 QZLJPM+Corbel CID TrueType Identity-H yes yes yes 69 0 MinionPro-Bold Type 1C Custom yes no yes 65 0 MinionPro-It Type 1C Custom yes no yes 66 0 PJAMBO+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 130 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-09-11 03:19:44 CEST RepresentationInformation: pmc_33986423.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-05-24 03:36:37 CEST Size: 818045 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 366 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline Children: Item: Title: Results Children: Item: Title: Patients’ characteristics. Item: Title: Plasmatic biomarkers level changes over time. Item: Title: Association between plasma biomarkers and cognitive decline. Item: Title: Association between inflammatory markers and NFL. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Patients. Item: Title: Biological assessment. Item: Title: Statistics. Item: Title: References Item: Title: Acknowledgements Info: Title: NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline Author: Constance Delaby Subject: Scientific Reports, https://doi.org/10.1038/s41598-021-89749-5 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri May 07 23:25:15 CEST 2021 ModDate: Sat May 08 08:13:00 CEST 2021 ID: 0x54f254806e50265a68cde6972ff4080d, 0xff2831904cda5930eb6acdde6a751f84 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: LCWAXW+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: QZLJPM+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FIQKUT+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: FIQKUT+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: PJAMBO+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PJAMBO+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: QZLJPM+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QZLJPM+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: LCWAXW+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LCWAXW+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2021-05-08T02:25:15+05:30 Springer 2021-05-08T08:13:00+02:00 2021-05-08T08:13:00+02:00 application/pdf https://doi.org/10.1038/s41598-021-89749-5 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-021-89749-5 NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline Constance Delaby A. Julian G. Page S. Ragot Sylvain Lehmann M. Paccalin 10.1038/s41598-021-89749-5 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-021-89749-5 10.1038/s41598-021-89749-5 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-021-89749-5 noindex springer.com springerlink.com VoR uuid:8140c347-7c06-4824-acd5-92b84835b2c3 uuid:53ade740-c327-458d-98ea-46da5067b62b default 1 converted uuid:58fe3f3f-a8fd-4c1b-8347-4244e95a44b0 converted to PDF/A-2b pdfToolbox 2021-05-08T02:25:28+05:30 converted uuid:000c7737-a400-480b-8840-7acdc448c321 converted to PDF/A-2b pdfToolbox 2021-05-08T02:25:50+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 264, 325, 267, 313 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 270, 325, 273, 313 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 219, 315, 221, 303 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 288, 255, 290, 243 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 292, 255, 295, 243 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 296, 255, 299, 243 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 351, 205, 357, 193 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 358, 205, 364, 193 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 549, 185, 552, 173 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 376, 175, 379, 163 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 476, 175, 479, 163 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 523, 175, 529, 163 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 386, 155, 391, 143 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 282, 145, 288, 133 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 481, 675, 556, 658 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 369, 424, 375, 412 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 358, 414, 364, 402 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 365, 414, 371, 402 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 345, 404, 348, 392 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 365, 394, 371, 382 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 399, 384, 405, 372 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 406, 384, 412, 372 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 457, 374, 463, 362 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 524, 354, 529, 342 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 251, 344, 254, 332 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 295, 344, 301, 332 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 196, 324, 202, 312 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 364, 314, 369, 302 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 387, 304, 392, 292 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 313, 294, 316, 282 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 318, 294, 323, 282 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 480, 284, 486, 272 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 528, 274, 531, 262 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 532, 274, 538, 262 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 180, 264, 183, 252 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 182, 254, 188, 242 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 455, 224, 461, 212 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 464, 224, 470, 212 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 498, 214, 503, 202 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 501, 194, 507, 182 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 176, 82, 181, 70 Flags: Print AppearanceDictionary: true Destination: 3 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 456, 398, 460, 385 Flags: Print AppearanceDictionary: true Destination: 76 Annotation: Subtype: Link Rect: 338, 152, 342, 139 Flags: Print AppearanceDictionary: true Destination: 92 Annotation: Subtype: Link Rect: 217, 92, 221, 79 Flags: Print AppearanceDictionary: true Destination: 92 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 344, 490, 350, 478 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 182, 390, 187, 378 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 442, 390, 448, 378 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 321, 380, 327, 368 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 328, 380, 334, 368 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 398, 370, 404, 358 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 417, 300, 423, 288 Flags: Print AppearanceDictionary: true Destination: 123 Annotation: Subtype: Link Rect: 425, 300, 430, 288 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 364, 250, 370, 238 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 305, 190, 311, 178 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 312, 190, 318, 178 Flags: Print AppearanceDictionary: true Destination: 139 Annotation: Subtype: Link Rect: 409, 68, 415, 56 Flags: Print AppearanceDictionary: true Destination: 139 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 211, 562, 217, 550 Flags: Print AppearanceDictionary: true Destination: 139 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 360, 461, 499, 451 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 454, 419, 554, 409 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 410, 226, 400 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 230, 410, 354, 400 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 499, 83, 554, 70 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 155, 72, 260, 60 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 351, 734, 443, 722 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 358, 624, 517, 612 Flags: Print AppearanceDictionary: true Thumb: true Checksum: ba2bb496 Type: CRC32 Checksum: d8558beccb4156f18d3040b2a20b617c Type: MD5 Checksum: a4799bb2676ab1930cd468372f110fe07c907ac0 Type: SHA-1