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Title:           BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet
Subject:         Molecular Metabolism, 53 (2021) 101251. doi:10.1016/j.molmet.2021.101251
Author:          Daniela Díaz-Catalán
Creator:         Elsevier
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     Item: 
      Title: BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet
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       Item: 
        Title: 1. Introduction
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       Item: 
        Title: 2. Materials and methods
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         Item: 
          Title: 2.1. Animals
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         Item: 
          Title: 2.2. Indirect calorimetry
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         Item: 
          Title: 2.3. Locomotor activity
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         Item: 
          Title: 2.4. Histochemistry
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         Item: 
          Title: 2.5. Glucose and insulin tolerance tests
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         Item: 
          Title: 2.6. Insulin and leptin determinations
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         Item: 
          Title: 2.7. Glucose-stimulated insulin secretion (GSIS)
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         Item: 
          Title: 2.8. Leptin sensitivity test
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         Item: 
          Title: 2.9. Central insulin signaling test
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         Item: 
          Title: 2.10. Western blot analysis
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         Item: 
          Title: 2.11. Immunofluorescence and quantitative image analysis
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         Item: 
          Title: 2.12. Gene expression analysis
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         Item: 
          Title: 2.13. Statistical analysis
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       Item: 
        Title: 3. Results
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        Children: 
         Item: 
          Title: 3.1. BKO mice develop exacerbated obesity and hyperphagia with altered energy metabolism after long-term HFD feeding
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         Item: 
          Title: 3.2. BKO mice exhibit enhanced insulin secretion under long-term HFD feeding
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         Item: 
          Title: 3.3. Pancreatic islets from BKO mice under HFD feeding display an exacerbated insulin secretion and β-cell proliferation
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         Item: 
          Title: 3.4. BKO mice show impaired leptin response and hypothalamic insulin signaling with altered neuropeptide expression
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         Item: 
          Title: 3.5. BKO mice show early hyperinsulinemia and insulin resistance following a short-term HFD regime
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         Item: 
          Title: 3.6. Pancreatic islets from BKO mice present a more pronounced β-cell proliferation and insulin secretion following a short HFD  ...
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        Title: 4. Discussion
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       Item: 
        Title: Authors’ contributions
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Conflict of interest
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       Item: 
        Title: Appendix A. Supplementary data
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       Item: 
        Title: References
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   Type: CRC32
  Checksum: af4151d2095287e3ec51ba61976c1180
   Type: MD5
  Checksum: 6a5cf46836cf693ff7068c60643f633444679688
   Type: SHA-1
  Checksum: 14b658db816f1bb86f600628755df377a9d9cec4ffc8ada6f07df1b0307d7fe2
   Type: SHA-256